Imperial College London
Dr Nazima Pathan

DrNazimaPathan

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

n.pathan

 
 
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Location

 

PICURoyal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pathan:2011,
author = {Pathan, N and Burmester, M and Adamovic, T and Berk, M and Ng, KW and Betts, H and Macrae, D and Waddell, S and Paul-Clark, M and Nuamah, R and Mein, C and Levin, M and Montana, G and Mitchell, JA},
journal = {American Journal of Respiratory & Critical Care Medicine},
pages = {1261--1269},
title = {Intestinal injury and endotoxemia in children undergoing surgery for congenital heart disease},
url = {http://ajrccm.atsjournals.org/cgi/reprint/201104-0715OCv1},
volume = {184},
year = {2011}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - RATIONALE: Children with congenital heart disease are at risk of gut barrier dysfunction and translocation of gut bacterial antigens into the bloodstream. This may contribute to inflammatory activation and organ dysfunction postoperatively.OBJECTIVES: To investigate the role of intestinal injury and endotoxemia in the pathogenesis of organ dysfunction after surgery for congenital heart disease.METHODS: We analyzed blood levels of intestinal fatty acid binding protein and endotoxin (endotoxin activity assay) alongside global transcriptomic profiling and assays of monocyte endotoxin receptor expression in children undergoing surgery for congenital heart disease.MEASUREMENTS AND MAIN RESULTS: Levels of intestinal fatty acid binding protein and endotoxin were greater in children with duct-dependent cardiac lesions. Endotoxemia was associated with severity of vital organ dysfunction and intensive care stay. We identified activation of pathogen-sensing, antigen-processing, and immune-suppressing pathways at the genomic level postoperatively and down-regulation of pathogen-sensing receptors on circulating immune cells.CONCLUSIONS: Children undergoing surgery for congenital heart disease are at increased risk of intestinal mucosal injury and endotoxemia. Endotoxin activity correlates with a number of outcome variables in this population, and may be used to guide the use of gut-protective strategies.
AU  - Pathan,N
AU  - Burmester,M
AU  - Adamovic,T
AU  - Berk,M
AU  - Ng,KW
AU  - Betts,H
AU  - Macrae,D
AU  - Waddell,S
AU  - Paul-Clark,M
AU  - Nuamah,R
AU  - Mein,C
AU  - Levin,M
AU  - Montana,G
AU  - Mitchell,JA
EP  - 1269
PY  - 2011///
SN  - 1073-449X
SP  - 1261
TI  - Intestinal injury and endotoxemia in children undergoing surgery for congenital heart disease
T2  - American Journal of Respiratory & Critical Care Medicine
UR  - http://ajrccm.atsjournals.org/cgi/reprint/201104-0715OCv1
VL  - 184
ER  -
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