Imperial College London


Faculty of MedicineDepartment of Infectious Disease

Honorary Clinical Research Fellow







Commonwealth BuildingHammersmith Campus





Nathan Peiffer-Smadja is a doctor specialized in Internal Medicine and Infectious Diseases and holds a PhD in Public Health.He is a Honorary Clinical Research Fellow at Imperial College London in the National Institute of Health Research (NIHR) Health Protection Research Unit in Healthcare Associated Infections and AMR and a research associate in the Inserm Infection, Antimicrobials, Modelling, Evolution (IAME) laboratory. He works as an Associate Professor in the Infectious and Tropical Diseases Department at the Bichat - Claude Bernard Academic Hospital, AP-HP, Paris, France.

His research focuses on the interface between electronic clinical decision support systems (CDSS) and implementation science, used in order to improve the day-to-day clinical management of infectious diseases, tropical diseases and emerging diseases. He has 8 years of clinical experience in French teaching hospitals and 4 years of experience in clinical research, mainly on the ways to optimize the use of antibiotics and in improving the treatment of COVID-19.

Selected publications

Antimicrobial stewardship

  1. Ahuja S, Peiffer-Smadja N, et al. Use of Feedback Data to Reduce Surgical Site Infections and Optimize Antibiotic Use in Surgery: A Systematic Scoping Review. Annals of Surgery, 2021
  2. Peiffer-Smadja N, et al. Performance and impact of a multiplex PCR in ICU patients with ventilator-associated pneumonia or ventilated hospital-acquired pneumonia. Critical Care, 2020
  3. Peiffer-Smadja N, et al. Paving the way for the implementation of a decision support system for antibiotic prescribing in primary care in West Africa: assessing contextual relevance and fit. Journal of Medical Internet Research, 2020
  4. Peiffer-Smadja N, et al. Preventing and Managing Urinary Tract Infections: Enhancing the Role of Community Pharmacists-A Mixed Methods Study. Antibiotics (Basel), 2020
  5. Peiffer-Smadja N, et al. Machine learning in the clinical microbiology laboratory: has the time come for routine practice? Clinical Microbiology and Infection, 2020
  6. Peiffer-Smadja N, et al. Machine learning for clinical decision support in infectious diseases: A narrative review of current applications. Clinical Microbiology and Infection, 2019


  1. Peiffer-Smadja N et al. Emergence of E484K Mutation Following Bamlanivimab Monotherapy among High-Risk Patients Infected with the Alpha Variant of SARS-CoV-2. Viruses, 2021
  2. Fiolet T, Kherabi Y, MacDonald CJ, Ghosn J, Peiffer-Smadja N. Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review. Clinical Microbiology and Infection, 2021
  3. Ader F, Bouscambert-Duchamp M, Hites M, Peiffer-Smadja N, et al. Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial. Lancet Infectious Diseases, 2021
  4. Ader F, Peiffer-Smadja N et al. An open-label randomized controlled trial of the effect of lopinavir/ritonavir, lopinavir/ritonavir plus IFN-β-1a and hydroxychloroquine in hospitalized patients with COVID-19. Clinical Microbiology and Infection, 2021
  5. Peiffer-Smadja N, et al. Anticovid, a comprehensive open-access real-time platform of registered clinical studies for COVID-19. Journal of Antimicrobial Chemotherapy, 2020
  6. Meppiel E, Peiffer-Smadja N et al. Neurological manifestations associated with COVID-19: a multicentric registry. Clinical Microbiology and Infection, 2020



Lingas G, Néant N, Gaymard A, et al., 2022, Effect of remdesivir on viral dynamics in COVID-19 hospitalized patients: a modelling analysis of the randomized, controlled, open-label DisCoVeRy trial., J Antimicrob Chemother, Vol:77, Pages:1404-1412

Bouiller K, Peiffer-Smadja N, Cevik M, et al., 2022, Role and perception of clinical microbiology and infectious diseases trainees during the COVID-19 crisis., Future Microbiol, Vol:17, Pages:411-416

Dellière S, Peiffer-Smadja N, João-Lopes M, et al., 2021, Aims and challenges of building national trainee networks in clinical microbiology and infectious disease disciplines., Future Microbiol, Vol:16, Pages:687-695

Maatoug R, Peiffer-Smadja N, Delval G, et al., 2021, Ecological Momentary Assessment Using Smartphones in Patients With Depression: Feasibility Study., Jmir Form Res, Vol:5

Birgand G, Peiffer-Smadja N, Fournier S, et al., 2020, Assessment of air contamination by SARS-CoV-2 in hospital settings, Jama Network Open, Vol:3, ISSN:2574-3805

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