Publications
38 results found
Penney N, Konan S, Hulme A, 2012, A rare combination of rare conditions: Salmonella septic sacroiliitis and hepatitis., BMJ Case Rep, Vol: 2012
We report an unusual presentation of sacroiliitis and hepatitis secondary to Salmonella systemic infection. A high index of suspicion, early blood cultures, prompt investigations and treatment with parenteral antibiotics can result in complete resolution of symptoms and prevent long-term sequelae of either condition.
Penney N, Phoenix G, De Souza B, 2012, Methicillin-resistant staphylococcus aureus (MRSA) screening in day surgery patients, International Journal of Surgery, Vol: 10, Pages: S49-S49, ISSN: 1743-9191
Patel R, Clancy R, Spencer R, et al., 2012, Single incision compared to standard laparoscopic cholecystectomy, International Journal of Surgery, Vol: 10, Pages: S40-S40, ISSN: 1743-9191
Clancy R, Patel R, Spencer R, et al., 2012, Single-incision compared to standard laparoscopic cholecystectomy, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY-BLACKWELL, Pages: 160-160, ISSN: 0007-1323
Penney N, Phoenix G, Ball S, et al., 2012, Radiographic assessment of the thumb, International Journal of Surgery, Vol: 10, Pages: S61-S61, ISSN: 1743-9191
Kinross J, von Roon AC, Penney N, et al., 2009, The gut microbiota as a target for improved surgical outcome and improved patient care, Current Pharmaceutical Design, Vol: 15, Pages: 1537-1545, ISSN: 1381-6128
The 'gut origin of sepsis' concept describes the role of the intestine in the development of sepsis and the postoperative Multi Organ Dysfunction Syndrome (MODS). Translocation of the microbiota from the gut into the systemic milieu is thought to be integral to this process. However, advances in molecular biology have demonstrated numerous mechanisms of interkingdom signalling within the gut and evidence suggests that the gut microbiota may directly influence the mammalian phenotype. The gut ecosystem fluctuates significantly in response to exogenous and surgical trauma yet until recently it has not been possible to study this non invasively and thus it is not known how current perioperative infection control strategies influence the microbiome and the consequences of this intervention for the host. However, novel analytical techniques such as metabonomics and metagenomics are permitting the in vivo analysis of the gut microbiome and are creating new avenues of research that have significant surgical applications. Furthermore, the protective mechanisms of commensal biota are increasingly being recognised, suggesting that perioperative modulation of the gut microbiome with pre, pro and synbiotics may beneficially influence surgical outcome. This paper reviews the role of the gut microbiome in determining surgical outcome, and highlights research into the mammalian microbial symbiotic axis which is leading to novel therapeutic interventions in surgery. © 2009 Bentham Science Publishers Ltd.
Kinross J, von Roon AC, Penney N, et al., 2009, The gut microbiota as a target for improved surgical outcome and improved patient care., Current pharmaceutical design, Vol: 15, Pages: 1537-1545, ISSN: 1381-6128
The 'gut origin of sepsis' concept describes the role of the intestine in the development of sepsis and the post-operative Multi Organ Dysfunction Syndrome (MODS). Translocation of the microbiota from the gut into the systemic milieu is thought to be integral to this process. However, advances in molecular biology have demonstrated numerous mechanisms of interkingdom signalling within the gut and evidence suggests that the gut microbiota may directly influence the mammalian phenotype. The gut ecosystem fluctuates significantly in response to exogenous and surgical trauma yet until recently it has not been possible to study this non invasively and thus it is not known how current perioperative infection control strategies influence the microbiome and the consequences of this intervention for the host. However, novel analytical techniques such as metabonomics and metagenomics are permitting the in vivo analysis of the gut microbiome and are creating new avenues of research that have significant surgical applications. Furthermore, the protective mechanisms of commensal biota are increasingly being recognised, suggesting that perioperative modulation of the gut microbiome with pre, pro and synbiotics may beneficially influence surgical outcome. This paper reviews the role of the gut microbiome in determining surgical outcome, and highlights research into the mammalian microbial symbiotic axis which is leading to novel therapeutic interventions in surgery.
Cloarec O, Dumas ME, Craig A, et al., 2005, Statistical total correlation spectroscopy:: An exploratory approach for latent biomarker identification from metabolic <SUP>1</SUP>H NMR data sets, ANALYTICAL CHEMISTRY, Vol: 77, Pages: 1282-1289, ISSN: 0003-2700
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