Imperial College London
Dr Nicholas Penney

DrNicholasPenney

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Research Fellow
 
 
 
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Contact

 

n.penney

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Currie:2021:bjs/znaa107,
author = {Currie, AC and Penney, N and Kamocka, A and Singh, P and Abbassi-Ghadi, N and Preston, SR},
doi = {bjs/znaa107},
journal = {British Journal of Surgery},
pages = {256--264},
title = {Systematic review on reporting of components and outcomes in randomized clinical trials of paraoesophageal hernia mesh repair},
url = {http://dx.doi.org/10.1093/bjs/znaa107},
volume = {108},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundSurgical interventions, such as paraoesophageal hernia (POH) repair, are complex with multiple components that require consideration in the reporting of clinical trials. Many aspects of POH repair, including mesh hiatal reinforcement and fundoplication type, are contentious. This review summarizes the reporting of components and outcomes in RCTs of POH repair.MethodsSystematic searches identified RCTs of POH repair published from 1995 to 2020. The patient selection criteria for RCT involvement were noted. The components of the surgical interventions in these RCTs were recorded using the CONSORT guidelines for non-pharmacological treatments, Template for Intervention Description and Replication (TIDieR) and Blencowe frameworks. The outcomes were summarized and definitions sought for critical variables, including recurrence.ResultsOf 1918 abstracts and 21 screened full-text articles, 12 full papers reporting on six RCTs were included in the review. The patient selection criteria and definitions of POH between trials varied considerably. Although some description of trial interventions was provided in all RCTs, this varied in depth and detail. Four RCTs described efforts to standardize the trial intervention. Outcomes were reported inconsistently, were rarely defined fully, and overall trial conclusions varied during follow-up.ConclusionThis lack of detail on the surgical intervention in POH repair RCTs prevents full understanding of what exact procedure was evaluated and how it should be delivered in clinical practice to gain the desired treatment effects. Improved focus on the definitions, descriptions and reporting of surgical interventions in POH repair is required for better future RCTs.
AU  - Currie,AC
AU  - Penney,N
AU  - Kamocka,A
AU  - Singh,P
AU  - Abbassi-Ghadi,N
AU  - Preston,SR
DO  - bjs/znaa107
EP  - 264
PY  - 2021///
SN  - 0007-1323
SP  - 256
TI  - Systematic review on reporting of components and outcomes in randomized clinical trials of paraoesophageal hernia mesh repair
T2  - British Journal of Surgery
UR  - http://dx.doi.org/10.1093/bjs/znaa107
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000642298200033&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://academic.oup.com/bjs/article/108/3/256/6118365
VL  - 108
ER  -
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