Imperial College London
Dr Nicholas Penney

DrNicholasPenney

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Research Fellow
 
 
 
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Contact

 

n.penney

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kinross:2013:10.1177/0148607112452306,
author = {Kinross, JMA and Markar, S and Karthikesalingam, A and Chow, A and Penney, N and Silk, D and Darzi, A},
doi = {10.1177/0148607112452306},
journal = {Journal of Parenteral and Enteral Nutrition},
pages = {243--253},
title = {A meta-analysis of probiotic and synbiotic use in elective surgery: Does nutrition modulation of the gut microbiome improve clinical outcome?},
url = {http://dx.doi.org/10.1177/0148607112452306},
volume = {37},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Perioperative nutrition modulation of gut microbiota is increasingly used as a strategy for reducing the infective complications of elective surgery. This meta-analysis assessed the effect of probiotic and synbiotic preparations on the incidence of postoperative sepsis. Methods: Randomized controlled trials that compared preoperative dosing of probiotics and synbiotics in patients undergoing elective general surgical procedures were included. The primary outcome measure was the postoperative sepsis rate. Pooled outcome measures were determined using random effects models. Results: Thirteen randomized controlled trials totaling 962 patients were included in this analysis (304 received synbiotics and 182 received probiotics). The incidence of postoperative sepsis was reduced in the probiotic group vs the control (pooled odds ratio [OR] = 0.42; 95% confidence interval [CI], 0.23-0.75; P =.003) and in the synbiotic group vs the control (pooled OR = 0.25; 95% CI, 0.1-0.6; P =.002). However, subgroup analysis failed to identify a significant reduction in the incidence of pneumonia, urinary tract infections, or wound infections in the postoperative phase for either treatment group. Synbiotics reduced the length of postoperative antibiotic use (weighted mean differences = -1.71; 95% CI, -3.2 to -0.21; P =.03). Conclusion: Probiotic and synbiotic nutrition strategies reduce the incidence of postoperative sepsis in the elective general surgery setting. These effects appear more pronounced with the use of synbiotics. High-powered, mechanistic studies are now required for the optimization of pro- and prebiotic regimens to further improve their efficacy. © 2012 American Society for Parenteral and Enteral Nutrition.
AU  - Kinross,JMA
AU  - Markar,S
AU  - Karthikesalingam,A
AU  - Chow,A
AU  - Penney,N
AU  - Silk,D
AU  - Darzi,A
DO  - 10.1177/0148607112452306
EP  - 253
PY  - 2013///
SN  - 0148-6071
SP  - 243
TI  - A meta-analysis of probiotic and synbiotic use in elective surgery: Does nutrition modulation of the gut microbiome improve clinical outcome?
T2  - Journal of Parenteral and Enteral Nutrition
UR  - http://dx.doi.org/10.1177/0148607112452306
VL  - 37
ER  -
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