Publications
486 results found
Jarman JWE, Wong T, Kojodjojo P, et al., 2014, Organizational Index Mapping to Identify Focal Sources During Persistent Atrial Fibrillation, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 25, Pages: 355-363, ISSN: 1045-3873
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- Citations: 26
Jamil-Copley S, Bokan R, Kojodjojo P, et al., 2014, Noninvasive electrocardiographic mapping to guide ablation of outflow tract ventricular arrhythmias, HEART RHYTHM, Vol: 11, Pages: 587-594, ISSN: 1547-5271
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- Citations: 60
Dias P, Desplantez T, El-Harasis MA, et al., 2014, Characterisation of Connexin Expression and Electrophysiological Properties in Stable Clones of the HL-1 Myocyte Cell Line, PLOS ONE, Vol: 9, ISSN: 1932-6203
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- Citations: 26
Kyriacou A, Pabari PA, Mayet J, et al., 2014, Cardiac resynchronization therapy and AV optimization increase myocardial oxygen consumption, but increase cardiac function more than proportionally, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 171, Pages: 144-152, ISSN: 0167-5273
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- Citations: 12
Ciaccio EJ, Ashikaga H, Coromilas J, et al., 2014, Model of Bipolar Electrogram Fractionation and Conduction Block Associated With Activation Wavefront Direction at Infarct Border Zone Lateral Isthmus Boundaries, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 7, Pages: 152-163, ISSN: 1941-3149
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- Citations: 21
Cantwell CD, Yakovlev S, Kirby RM, et al., 2014, High-order spectral/hp element discretisation for reaction-diffusion problems on surfaces: application to cardiac electrophysiology, Journal of Computational Physics, Vol: 257, Pages: 813-829, ISSN: 0021-9991
We present a numerical discretisation of an embedded two-dimensional manifold using high-order continuous Galerkin spectral/hp elements, which provide exponential convergence of the solution with increasing polynomial order, while retaining geometric flexibility in the representation of the domain. Our work is motivated by applications in cardiac electrophysiology where sharp gradients in the solution benefit from the high-order discretisation, while the compu- tational cost of anatomically-realistic models can be reduced through the surface representation. We describe and validate our discretisation and provide a demonstration of its application to modeling electrochemical propagation across a human left atrium.
Dhillon PS, Gray R, Kojodjojo P, et al., 2013, Relationship Between Gap-Junctional Conductance and Conduction Velocity in Mammalian Myocardium, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 6, Pages: 1208-1214, ISSN: 1941-3149
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- Citations: 50
Jamil-Copley S, Linton N, Koa-Wing M, et al., 2013, Application of Ripple Mapping with an Electroanatomic Mapping System for Diagnosis of Atrial Tachycardias, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 24, Pages: 1361-1369, ISSN: 1045-3873
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- Citations: 25
Walsh R, Peters NS, Cook SA, et al., 2013, Paralogue annotation identifies novel pathogenic variants in patients with Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia, Journal of Medical Genetics, Vol: 51, Pages: 35-44, ISSN: 1468-6244
Background Distinguishing genetic variants that causedisease from variants that are rare but benign is one ofthe principal challenges in contemporary clinicalgenetics, particularly as variants are identified at a paceexceeding the capacity of researchers to characterisethem functionally.Methods We previously developed a novel method,called paralogue annotation, which accurately andspecifically identifies disease-causing missense variants bytransferring disease-causing annotations across families ofrelated proteins. Here we refine our approach, and applyit to novel variants found in 2266 patients across twolarge cohorts with inherited sudden death syndromes,namely catecholaminergic polymorphic ventriculartachycardia (CPVT) or Brugada syndrome (BrS).Results Over one third of the novel non-synonymousvariants found in these studies, which would otherwisebe reported in a clinical diagnostics setting as ‘variants ofunknown significance’, are categorised by our method aslikely disease causing (positive predictive value 98.7%).This identified more than 500 new disease loci for BrSand CPVT.Conclusions Our methodology is widely transferableacross all human disease genes, with an estimated150 000 potentially informative annotations in more than1800 genes. We have developed a web resource thatallows researchers and clinicians to annotate variantsfound in individuals with inherited arrhythmias,comprising a referenced compendium of known missensevariants in these genes together with a user-friendlyimplementation of our approach. This tool will facilitatethe interpretation of many novel variants that mightotherwise remain unclassified.
Kyriacou A, Wa MELK, Pabari PA, et al., 2013, A systematic approach to designing reliable VV optimization methodology: Assessment of internal validity of echocardiographic, electrocardiographic and haemodynamic optimization of cardiac resynchronization therapy, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 167, Pages: 954-964, ISSN: 0167-5273
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- Citations: 7
Malcolme-Lawes LC, Juli C, Karim R, et al., 2013, Automated analysis of atrial late gadolinium enhancement imaging that correlates with endocardial voltage and clinical outcomes: A 2-center study, HEART RHYTHM, Vol: 10, Pages: 1184-1191, ISSN: 1547-5271
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- Citations: 104
Bai W, Shi W, O'Regan DP, et al., 2013, A probabilistic patch-based label fusion model for multi-atlas segmentation with registration refinement: application to cardiac MR images, IEEE Transactions on Medical Imaging, Vol: 32, Pages: 1302-1315, ISSN: 0278-0062
The evaluation of ventricular function is important for the diagnosis of cardiovascular diseases. It typically involves measurement of the left ventricular (LV) mass and LV cavity volume. Manual delineation of the myocardial contours is time-consuming and dependent on the subjective experience of the expert observer. In this paper, a multi-atlas method is proposed for cardiac magnetic resonance (MR) image segmentation. The proposed method is novel in two aspects. First, it formulates a patch-based label fusion model in a Bayesian framework. Second, it improves image registration accuracy by utilizing label information, which leads to improvement of segmentation accuracy. The proposed method was evaluated on a cardiac MR image set of 28 subjects. The average Dice overlap metric of our segmentation is 0.92 for the LV cavity, 0.89 for the right ventricular cavity and 0.82 for the myocardium. The results show that the proposed method is able to provide accurate information for clinical diagnosis.
Ng FS, Shadi IT, Peters NS, et al., 2013, Selective heart rate reduction with ivabradine slows ischaemia-induced electrophysiological changes and reduces ischaemia-reperfusion-induced ventricular arrhythmias, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 59, Pages: 67-75, ISSN: 0022-2828
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- Citations: 23
Malcolme-Lawes LC, Lim PB, Wright I, et al., 2013, Characterization of the Left Atrial Neural Network and its Impact on Autonomic Modification Procedures, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 6, Pages: 632-640, ISSN: 1941-3149
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- Citations: 40
Hunter RJ, Jones DA, Boubertakh R, et al., 2013, Diagnostic Accuracy of Cardiac Magnetic Resonance Imaging in the Detection and Characterization of Left Atrial Catheter Ablation Lesions: A Multicenter Experience, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 24, Pages: 396-403, ISSN: 1045-3873
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- Citations: 60
Hayat SA, Kojodjojo P, Mason A, et al., 2013, Malfunction of Subpectorally Implanted Cardiac Resynchronization Therapy Defibrillators Due to Weakened Header Bond, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 24, Pages: 351-355, ISSN: 1045-3873
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- Citations: 2
Zaman JAB, Al-Aidarous S, Patel PM, et al., 2013, The contact electrogram and its architectural determinants in atrial fibrillation, Spring Meeting for Clinician Scientists in Training, Publisher: ELSEVIER SCIENCE INC, Pages: 118-118, ISSN: 0140-6736
Ware JS, John S, Roberts AM, et al., 2013, Next Generation Diagnostics in Inherited Arrhythmia Syndromes, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 6, Pages: 94-103, ISSN: 1937-5387
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- Citations: 26
Malcolme-Lawes LC, Lim PB, Koa-Wing M, et al., 2013, Robotic assistance and general anaesthesia improve catheter stability and increase signal attenuation during atrial fibrillation ablation, EUROPACE, Vol: 15, Pages: 41-47, ISSN: 1099-5129
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- Citations: 18
Kyriacou A, Whinnett ZI, Sen S, et al., 2012, Improvement in Coronary Blood Flow Velocity With Acute Biventricular Pacing Is Predominantly Due to an Increase in a Diastolic Backward-Travelling Decompression (Suction) Wave, CIRCULATION, Vol: 126, Pages: 1334-+, ISSN: 0009-7322
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- Citations: 28
Paur H, Wright PT, Sikkel MB, et al., 2012, High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathy., Circulation Journal, Vol: 6, Pages: 697-706
Jarman JW, Wong T, Kojodojojo P, et al., 2012, Spatiotemporal behavior of high dominant frequency during paroxysmal and persistent atrial fibrillation in the human left atrium., Circ Arrhythm Electrophysiol., Vol: 4, Pages: 650-658
BACKGROUNDSites of high dominant frequency (DF(peak)) are thought to indicate the location of drivers of atrial fibrillation (AF), but characterization of their spatiotemporal distribution and stability, critical to their relevance as targets for catheter ablation, requires simultaneous global mapping of the left atrium.METHODS AND RESULTS:Noncontact electrograms recorded simultaneously from 256 left atrial sites during spontaneous AF were analyzed. After subtraction of the ventricular component, fast Fourier transform identified the DF at each site. Focal areas of DF(peak) were defined as those having a DF >20% above all neighboring sites. Twenty-four patients with spontaneous AF (11 paroxysmal and 13 persistent) were studied. In paroxysmal AF, sites of DF(peak) (mean DF, 11.6±2.9 Hz) were observed in 100% of patients (present during 65% of the mapping period). In contrast, DF(peak) was detected in only 31% of patients with persistent AF (P<0.001) and for only 5% of the mapping period (P<0.001). In both groups, locations of DF(peak) varied widely in both consecutive and separated segments of AF (κ coefficient range, -0.07-0.22). Activation sequences around sites of DF(peak) did not demonstrate centrifugal activation that would be expected from focal drivers.CONCLUSIONS:Focal areas of high DF are more frequent in paroxysmal than persistent AF, are spatiotemporally unstable, are not the source of centrifugal activation, and are not, therefore, indicative of fixed drivers of AF. In the absence of spatiotemporal stability, the success of ablation at sites of DF(peak) cannot be explained by elimination of fixed drivers.
Jarman JW, Wong T, Kojodjojo P, et al., 2012, Spatiotemporal Behaviour ofHigh Dominant Frequency during Paroxysmal and Persistent Atrial Fibrillation inthe Human Left Atrium, Circ Arrhythm Electrophysiol, Vol: 5, Pages: 650-658, ISSN: 1941-3149
Tondato F, Robinson K, Cui J, et al., 2012, Effects on Arrhythmogenesis and Arrhythmic Threshold of Injection of Autologous Fibroblasts into Myocardial Infarcts in Adult Pigs, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 5, Pages: 337-344, ISSN: 1937-5387
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- Citations: 4
Blakeway E, Jabbour RJ, Baksi J, et al., 2012, ECGs: Colour-coding for initial training, RESUSCITATION, Vol: 83, Pages: E115-E116, ISSN: 0300-9572
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- Citations: 2
Al-Aidarous SI, Roney CH, Peters FMD, et al., 2012, CONDUCTION BLOCK INDUCED BY ACIDOSIS IN HL-1 MOUSE ATRIAL MYOCYTES CAN BE REVERSED BY ADMINISTERING THE GAP JUNCTIONAL COUPLER ROTIGAPTIDE, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: B M J PUBLISHING GROUP, Pages: A66-A66, ISSN: 1355-6037
Roney CH, Ng FS, Chowdhury RA, et al., 2012, Hysteresis of cardiac action potential duration restitution occurs in the absence of calcium transient duration hysteresis - a dual optical mapping study of ex vivo rat hearts, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S63-S63, ISSN: 0008-6363
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- Citations: 1
Wit AL, Peters NS, 2012, The role of gap junctions in the arrhythmias of ischemia and infarction, HEART RHYTHM, Vol: 9, Pages: 308-311, ISSN: 1547-5271
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- Citations: 29
Lyon AR, Nikolaev VO, Miragoli M, et al., 2012, Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure, Circulation: Heart Failure, Vol: 5, Pages: 357-365
Connolly SJ, Camm AJ, Halperin JL, et al., 2011, Dronedarone in High-Risk Permanent Atrial Fibrillation, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 365, Pages: 2268-2276, ISSN: 0028-4793
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- Citations: 433
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