Imperial College London
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ProfessorNicholasPeters

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiac Electrophysiology
 
 
 
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Contact

 

+44 (0)20 7594 1880n.peters Website

 
 
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Assistant

 

Ms Anastasija Schmidt +44 (0)20 7594 1880

 
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Location

 

NHLI officesSir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ciacci:2020:10.1103/PhysRevResearch.2.023311,
author = {Ciacci, A and Falkenberg, M and Manani, KA and Evans, TS and Peters, NS and Christensen, K},
doi = {10.1103/PhysRevResearch.2.023311},
journal = {Physical Review Research},
pages = {1--23},
title = {Understanding the transition from paroxysmal to persistent atrial fibrillation},
url = {http://dx.doi.org/10.1103/PhysRevResearch.2.023311},
volume = {2},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Atrial fibrillation (AF) is the most common cardiac arrhytmia, characterisedby the chaotic motion of electrical wavefronts in the atria. In clinicalpractice, AF is classified under two primary categories: paroxysmal AF, shortintermittent episodes separated by periods of normal electrical activity, andpersistent AF, longer uninterrupted episodes of chaotic electrical activity.However, the precise reasons why AF in a given patient is paroxysmal orpersistent is poorly understood. Recently, we have introduced the percolationbased Christensen-Manani-Peters (CMP) model of AF which naturally exhibits bothparoxysmal and persistent AF, but precisely how these differences emerge in themodel is unclear. In this paper, we dissect the CMP model to identify the causeof these different AF classifications. Starting from a mean-field model wherewe describe AF as a simple birth-death process, we add layers of complexity tothe model and show that persistent AF arises from the formation of temporallystable structural re-entrant circuits that form from the interaction ofwavefront collisions during paroxysmal AF. These results are compatible withrecent findings suggesting that the formation of re-entrant drivers in fibroticborder zones perpetuates persistent AF.
AU  - Ciacci,A
AU  - Falkenberg,M
AU  - Manani,KA
AU  - Evans,TS
AU  - Peters,NS
AU  - Christensen,K
DO  - 10.1103/PhysRevResearch.2.023311
EP  - 23
PY  - 2020///
SN  - 2643-1564
SP  - 1
TI  - Understanding the transition from paroxysmal to persistent atrial fibrillation
T2  - Physical Review Research
UR  - http://dx.doi.org/10.1103/PhysRevResearch.2.023311
UR  - http://arxiv.org/abs/1908.01646
UR  - https://journals.aps.org/prresearch/abstract/10.1103/PhysRevResearch.2.023311
UR  - http://hdl.handle.net/10044/1/73832
VL  - 2
ER  -
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