Imperial College London
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ProfessorNicholasPeters

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiac Electrophysiology
 
 
 
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Contact

 

+44 (0)20 7594 1880n.peters Website

 
 
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Assistant

 

Ms Anastasija Schmidt +44 (0)20 7594 1880

 
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Location

 

NHLI officesSir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ng:2020:10.3389/fphys.2020.00987,
author = {Ng, FS and Handa, B and Li, X and Peters, N},
doi = {10.3389/fphys.2020.00987},
journal = {Frontiers in Physiology},
pages = {1--7},
title = {Towards mechanism-directed electrophenotype-based treatments for atrial fibrillation},
url = {http://dx.doi.org/10.3389/fphys.2020.00987},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Current treatment approaches for persistent atrial fibrillation (AF) have a ceiling of success of around 50%. This is despite 15 years of developing adjunctive ablation strategies in addition to pulmonary vein isolation to target the underlying arrhythmogenic substrate in AF. A major  shortcoming of our current approach to AF treatment is its predominantly empirical nature. This has in part been due to a lack of consensus on the mechanisms that sustain human AF.6 In this article, we review evidence suggesting that the previous debates on AF being eitheran organised arrhythmia with a focal driver ora disorganised rhythm sustained by multiple wavelets, may prove to be a false dichotomy. Instead,a range of fibrillation electrophenotypes exists along a continuous spectrum, and the predominant mechanism in an individual case is determined by the nature and extent of remodelling of the underlying substrate. We propose moving beyond the current empirical approach to AF treatment, and highlight the need to prescribe AF treatments based on the underlying AFelectrophenotype, and review several possible novel mapping algorithms that may be useful in discerning the AF electrophenotype to guide tailored treatments, including Granger Causality mapping.
AU  - Ng,FS
AU  - Handa,B
AU  - Li,X
AU  - Peters,N
DO  - 10.3389/fphys.2020.00987
EP  - 7
PY  - 2020///
SN  - 1664-042X
SP  - 1
TI  - Towards mechanism-directed electrophenotype-based treatments for atrial fibrillation
T2  - Frontiers in Physiology
UR  - http://dx.doi.org/10.3389/fphys.2020.00987
UR  - https://www.frontiersin.org/articles/10.3389/fphys.2020.00987/full
UR  - http://hdl.handle.net/10044/1/81496
VL  - 11
ER  -
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