Imperial College London
Alternate

Professor Neil Poulter

Faculty of Medicine, School of Public Health

Professor of Preventive Cardiovascular Medicine.
 
 
 
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Contact

 

+44 (0)20 7594 3446n.poulter

 
 
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Assistant

 

Mrs Ranjit Rayat +44 (0)20 7594 3445

 
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Location

 

55Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ojji:2018:10.1016/j.ahj.2018.03.023,
author = {Ojji, DB and Poulter, N and Damasceno, A and Sliwa, K and Smythe, W and Kramer, N and Badri, M and Francis, V and Aje, A and Barasa, F and Dzudie, A and Jones, E and Kana, SS and Mntla, P and Mondo, C and Ogah, O and Ogola, EN and Ogunbanjo, G and Okpechi, I and Shedul, G and Sani, MU and Shedul, G and Mayosi, BM},
doi = {10.1016/j.ahj.2018.03.023},
journal = {American Heart Journal},
pages = {5--12},
title = {Rationale and design of the comparison of 3 combination therapies in lowering blood pressure in black Africans (CREOLE study): 2 × 3 factorial randomized single-blind multicenter trial},
url = {http://dx.doi.org/10.1016/j.ahj.2018.03.023},
volume = {202},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Current hypertension guidelines recommend the use of combination therapy as first-line treatment or early in the management of hypertensive patients. Although there are many possible combinations of blood pressure(BP)-lowering therapies, the best combination for the black population is still a subject of debate because no large randomized controlled trials have been conducted in this group to compare the efficacy of different combination therapies to address this issue. METHODS: The comparison of 3 combination therapies in lowering BP in the black Africans (CREOLE) study is a randomized single-blind trial that will compare the efficacy of amlodipine plus hydrochlorothiazide versus amlodipine plus perindopril and versus perindopril plus hydrochlorothiazide in blacks residing in sub-Saharan Africa (SSA). Seven hundred two patients aged 30-79years with a sitting systolic BP of 140 mm Hg and above, and less than 160mm Hg on antihypertensive monotherapy, or sitting systolic BP of 150mm Hg and above, and less than 180mm Hg on no treatment, will be centrally randomized into any of the 3 arms (234 into each arm). The CREOLE study is taking place in 10 sites in SSA, and the primary outcome measure is change in ambulatory systolic BP from baseline to 6months. The first patient was randomized in June 2017, and the trial will be concluded by 2019. CONCLUSIONS: The CREOLE trial will provide unique information as to the most efficacious 2-drug combination in blacks residing in SSA and thereby inform the development of clinical guidelines for the treatment of hypertension in this subregion.
AU  - Ojji,DB
AU  - Poulter,N
AU  - Damasceno,A
AU  - Sliwa,K
AU  - Smythe,W
AU  - Kramer,N
AU  - Badri,M
AU  - Francis,V
AU  - Aje,A
AU  - Barasa,F
AU  - Dzudie,A
AU  - Jones,E
AU  - Kana,SS
AU  - Mntla,P
AU  - Mondo,C
AU  - Ogah,O
AU  - Ogola,EN
AU  - Ogunbanjo,G
AU  - Okpechi,I
AU  - Shedul,G
AU  - Sani,MU
AU  - Shedul,G
AU  - Mayosi,BM
DO  - 10.1016/j.ahj.2018.03.023
EP  - 12
PY  - 2018///
SN  - 0002-8703
SP  - 5
TI  - Rationale and design of the comparison of 3 combination therapies in lowering blood pressure in black Africans (CREOLE study): 2 × 3 factorial randomized single-blind multicenter trial
T2  - American Heart Journal
UR  - http://dx.doi.org/10.1016/j.ahj.2018.03.023
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29800784
UR  - http://hdl.handle.net/10044/1/61837
VL  - 202
ER  -
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