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@article{Thomas:2018:10.1161/JAHA.117.008226,
author = {Thomas, MC and Woodward, M and Li, Q and Pickering, R and Tikellis, C and Poulter, N and Cooper, ME and Marre, M and Zoungas, S and Chalmers, J and ADVANCE, Collaborative Group},
doi = {10.1161/JAHA.117.008226},
journal = {Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease},
title = {Relationship Between Plasma 8-OH-Deoxyguanosine and Cardiovascular Disease and Survival in Type 2 Diabetes Mellitus: Results From the ADVANCE Trial.},
url = {http://dx.doi.org/10.1161/JAHA.117.008226},
volume = {7},
year = {2018}
}

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TY  - JOUR
AB  - BACKGROUND: 8-Oxo-2'-deoxyguanosine (8-oxo-2'-dG) is a biomarker of oxidative DNA damage that is associated with cardiovascular disease and premature mortality in the general population. Although oxidative stress has a proven role in cardiovascular complications in diabetes mellitus, evidence for a relationship between plasma 8-oxo-2'-dG and major cardiovascular outcomes in diabetes mellitus is weak. METHODS AND RESULTS: A case-cohort study was performed in 3766 participants with prevalent diabetes mellitus in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation) trial (ClinicalTrials.gov number NCT00145925). The hazard ratios for mortality and major acute cardiovascular events were derived using Cox regression models. During a median of 5 years of follow-up, 695 (18.4%) participants in this enriched cohort died (including 354 deaths from cardiovascular disease). Individuals with higher levels of 8-oxo-2'-dG were more likely to die. After adjusting for cardiovascular disease risk factors, the hazard ratio for a 1-SD increase in plasma 8-oxo-2'-dG was 1.10 (95% confidence interval, 1.01-1.20; P=0.03). This was driven by an independent association between plasma 8-oxo-2'-dG and cardiovascular death (hazard ratio, 1.23; 95% confidence interval, 1.10-1.37 [P<0.001]). By contrast, no association was seen between 8-oxo-2'-dG and noncardiovascular disease death (of which cancer was the major single cause). 8-Oxo-2'-dG was also not significantly associated with either nonfatal myocardial infarction or nonfatal stroke. CONCLUSIONS: In adults with type 2 diabetes mellitus, increased levels of 8-oxo-2'-dG are independently associated with all-cause mortality and cardiovascular mortality in adults with longstanding type 2 diabetes mellitus who participated in the ADVANCE trial, consistent with the role of oxidative damage in the development and progression of cardiovascular decompensation in diabetes mellitu
AU  - Thomas,MC
AU  - Woodward,M
AU  - Li,Q
AU  - Pickering,R
AU  - Tikellis,C
AU  - Poulter,N
AU  - Cooper,ME
AU  - Marre,M
AU  - Zoungas,S
AU  - Chalmers,J
AU  - ADVANCE,Collaborative Group
DO  - 10.1161/JAHA.117.008226
PY  - 2018///
SN  - 2047-9980
TI  - Relationship Between Plasma 8-OH-Deoxyguanosine and Cardiovascular Disease and Survival in Type 2 Diabetes Mellitus: Results From the ADVANCE Trial.
T2  - Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease
UR  - http://dx.doi.org/10.1161/JAHA.117.008226
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29960985
UR  - http://hdl.handle.net/10044/1/61356
VL  - 7
ER  -

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