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@article{Giri:2019:10.1038/s41588-018-0303-9,
author = {Giri, A and Hellwege, JN and Keaton, JM and Park, J and Qiu, C and Warren, HR and Torstenson, ES and Kovesdy, CP and Sun, YV and Wilson, OD and Robinson-Cohen, C and Roumie, CL and Chung, CP and Birdwell, KA and Damrauer, SM and DuVall, SL and Klarin, D and Cho, K and Wang, Y and Evangelou, E and Cabrera, CP and Wain, LV and Shrestha, R and Mautz, BS and Akwo, EA and Sargurupremraj, M and Debette, S and Boehnke, M and Scott, LJ and Luan, J and Zhao, J-H and Willems, SM and Theriault, S and Shah, N and Oldmeadow, C and Almgren, P and Li-Gao, R and Verweij, N and Boutin, TS and Mangino, M and Ntalla, I and Feofanova, E and Surendran, P and Cook, JP and Karthikeyan, S and Lahrouchi, N and Liu, C and Sepulveda, N and Richardson, TG and Kraja, A and Amouyel, P and Farrall, M and Poulter, NR and Laakso, M and Zeggini, E and Sever, P and Scott, RA and Langenberg, C and Wareham, NJ and Conen, D and Palmer, CNA and Attia, J and Chasman, DI and Ridker, PM and Melander, O and Mook-Kanamori, DO an},
doi = {10.1038/s41588-018-0303-9},
journal = {Nature Genetics},
pages = {51--62},
title = {Trans-ethnic association study of blood pressure determinants in over 750,000 individuals},
url = {http://dx.doi.org/10.1038/s41588-018-0303-9},
volume = {51},
year = {2019}
}

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TY  - JOUR
AB  - In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
AU  - Giri,A
AU  - Hellwege,JN
AU  - Keaton,JM
AU  - Park,J
AU  - Qiu,C
AU  - Warren,HR
AU  - Torstenson,ES
AU  - Kovesdy,CP
AU  - Sun,YV
AU  - Wilson,OD
AU  - Robinson-Cohen,C
AU  - Roumie,CL
AU  - Chung,CP
AU  - Birdwell,KA
AU  - Damrauer,SM
AU  - DuVall,SL
AU  - Klarin,D
AU  - Cho,K
AU  - Wang,Y
AU  - Evangelou,E
AU  - Cabrera,CP
AU  - Wain,LV
AU  - Shrestha,R
AU  - Mautz,BS
AU  - Akwo,EA
AU  - Sargurupremraj,M
AU  - Debette,S
AU  - Boehnke,M
AU  - Scott,LJ
AU  - Luan,J
AU  - Zhao,J-H
AU  - Willems,SM
AU  - Theriault,S
AU  - Shah,N
AU  - Oldmeadow,C
AU  - Almgren,P
AU  - Li-Gao,R
AU  - Verweij,N
AU  - Boutin,TS
AU  - Mangino,M
AU  - Ntalla,I
AU  - Feofanova,E
AU  - Surendran,P
AU  - Cook,JP
AU  - Karthikeyan,S
AU  - Lahrouchi,N
AU  - Liu,C
AU  - Sepulveda,N
AU  - Richardson,TG
AU  - Kraja,A
AU  - Amouyel,P
AU  - Farrall,M
AU  - Poulter,NR
AU  - Laakso,M
AU  - Zeggini,E
AU  - Sever,P
AU  - Scott,RA
AU  - Langenberg,C
AU  - Wareham,NJ
AU  - Conen,D
AU  - Palmer,CNA
AU  - Attia,J
AU  - Chasman,DI
AU  - Ridker,PM
AU  - Melander,O
AU  - Mook-Kanamori,DO
AU  - van,der Harst P
AU  - Cucca,F
AU  - Schlessinger,D
AU  - Hayward,C
AU  - Spector,TD
AU  - Jarvelin,M-R
AU  - Hennig,BJ
AU  - Timpson,NJ
AU  - Wei,W-Q
AU  - Smith,JC
AU  - Xu,Y
AU  - Matheny,ME
AU  - Siew,EE
AU  - Lindgren,C
AU  - Herzig,K-H
AU  - Dedoussis,G
AU  - Denny,JC
AU  - Psaty,BM
AU  - Howson,JMM
AU  - Munroe,PB
AU  - Newton-Cheh,C
AU  - Caulfield,MJ
AU  - Elliott,P
AU  - Gaziano,JM
AU  - Concato,J
AU  - Wilson,PWF
AU  - Tsao,PS
AU  - Edwards,DRV
AU  - Susztak,K
AU  - O'Donnell,CJ
AU  - Hung,AM
AU  - Edwards,TL
DO  - 10.1038/s41588-018-0303-9
EP  - 62
PY  - 2019///
SN  - 1061-4036
SP  - 51
TI  - Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/s41588-018-0303-9
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454108800013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/66717
VL  - 51
ER  -

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