Imperial College London
Alternate

Professor Neil Poulter

Faculty of Medicine, School of Public Health

Professor of Preventive Cardiovascular Medicine.
 
 
 
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Contact

 

+44 (0)20 7594 3446n.poulter

 
 
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Assistant

 

Mrs Ranjit Rayat +44 (0)20 7594 3445

 
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Location

 

55Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Amod:2020:10.1177/1479164120970933,
author = {Amod, A and Buse, JB and McGuire, DK and Pieber, TR and Pop-Busui, R and Pratley, RE and Zinman, B and Hansen, MB and Jia, T and Mark, T and Poulter, NR and DEVOTE, Study Group},
doi = {10.1177/1479164120970933},
journal = {Diabetes and Vascular Disease Research},
title = {Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12)},
url = {http://dx.doi.org/10.1177/1479164120970933},
volume = {17},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIM: To investigate risk factors associated with kidney disorders in patients with type 2 diabetes (T2D) at high cardiovascular (CV) risk. METHODS: In DEVOTE, a cardiovascular outcomes trial, 7637 patients were randomised to insulin degludec (degludec) or insulin glargine 100 units/mL (glargine U100), with standard of care. In these exploratory post hoc analyses, serious adverse event reports were searched using Standardised MedDRA® Queries related to chronic kidney disease (CKD) or acute kidney injury (AKI). Baseline predictors of CKD, AKI and change in estimated glomerular filtration rate (eGFR) were identified using stepwise selection and Cox or linear regression. RESULTS: Over 2 years, eGFR (mL/min/1.73 m2) decline was small and similar between treatments (degludec: 2.70; glargine U100: 2.92). Overall, 97 and 208 patients experienced CKD and AKI events, respectively. A history of heart failure was a risk factor for CKD (hazard ratio [HR] 1.97 [95% confidence interval [CI] 1.41; 2.75]) and AKI (HR 2.28 [95% CI 1.64; 3.17]). A history of hepatic impairment was a significant predictor of CKD (HR 3.28 [95% CI 2.12; 5.07]) and change in eGFR (estimate: -8.59 [95% CI -10.20; -7.00]). CONCLUSION: Our findings indicate that traditional, non-modifiable risk factors for kidney disorders apply to insulin-treated patients with T2D at high CV risk. TRIAL REGISTRATION: NCT01959529 (ClinicalTrials.gov).
AU  - Amod,A
AU  - Buse,JB
AU  - McGuire,DK
AU  - Pieber,TR
AU  - Pop-Busui,R
AU  - Pratley,RE
AU  - Zinman,B
AU  - Hansen,MB
AU  - Jia,T
AU  - Mark,T
AU  - Poulter,NR
AU  - DEVOTE,Study Group
DO  - 10.1177/1479164120970933
PY  - 2020///
SN  - 1479-1641
TI  - Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12)
T2  - Diabetes and Vascular Disease Research
UR  - http://dx.doi.org/10.1177/1479164120970933
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33280425
UR  - http://hdl.handle.net/10044/1/90543
VL  - 17
ER  -
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