Imperial College London

Dr Nick Quaife

Faculty of MedicineNational Heart & Lung Institute

Research Postgraduate







Guy Scadding BuildingRoyal Brompton Campus





Nick is a Wellcome/Imperial 4i Clinical PhD Scholar working in the lab of Professor Stuart Cook at the National Heart and Lung Institute, and a Specialist Registrar in Cardiology at Imperial College NHS Trust and The Royal Brompton Hospital.

He is investigating the role of recently described genetic elements, called small open reading frames (smORFs), in myocardial fibrosis – the scarring of heart tissue in disease. Better understanding these could lead to the development of novel treatments in heart failure.

Nick completed a BSc in Biochemistry and Genetics at the University of Nottingham, with a dissertation in cardiomyocyte differentiation under Professors Keith Campbell and Chris Denning.  He went on to study medicine at the University of Sheffield, and was awarded the Yorkshire and Humber Academic Gold Medal for developing the first fully in vivo model of endothelial repair during his NIHR Academic Foundation Programme, with Professor Tim Chico.

He completed Core Medical Training at the Royal Brompton and Northwick Park Hospitals, and became a member of the Royal College of Physicians in 2013. Nick further attained a NIHR Academic Clinical Fellowship in Cardiology at Imperial College London in 2014, and worked with Professor Nadia Rosenthal at the Australian Regenerative Medicine Institute in Melbourne, evaluating the role of axolotl pluripotency factors in myocardial regeneration.

Nick collaborates closely with the lab of Professor Cesare Terracciano, and recently co-authored a British Heart Foundation project grant investigating the role of mechanical stress in fibrosis, using the myocardial slice model.

Nick is accredited in transthoracic echocardiography by the British Society of Echocardiography.

He thinks that collaboration and broad-reaching pragmatism is essential in research, and for general cardiovascular health.



Wright CF, Quaife NM, Ramos-Hernández L, et al., 2021, Non-coding region variants upstream of MEF2C cause severe developmental disorder through three distinct loss-of-function mechanisms, American Journal of Human Genetics, Vol:108, ISSN:0002-9297, Pages:1083-1094

Whiffin N, Karczewski KJ, Zhang X, et al., 2021, Characterising the loss-of-function impact of 5 ' untranslated region variants in 15,708 individuals (vol 11, 2523, 2020), Nature Communications, Vol:12, ISSN:2041-1723, Pages:1-1

Whiffin N, Armean IM, Kleinman A, et al., 2020, The effect of LRRK2 loss-of-function variants in humans, Nature Medicine, Vol:26, ISSN:1078-8956, Pages:869-+

Whiffin N, Karczewski KJ, Zhang X, et al., 2020, Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals, Nature Communications, Vol:11, ISSN:2041-1723, Pages:1-12

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