Imperial College London
Professor Nick Quirke

ProfessorNickQuirke

Faculty of Natural Sciences, Department of Chemistry

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 5844n.quirke

 
 
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Location

 

Molecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kokot:2020:10.1002/adma.202003913,
author = {Kokot, H and Kokot, B and Sebastijanovi, A and Voss, C and Podlipec, R and Zawilska, P and Berthing, T and López, CB and Danielsen, PH and Contini, C and Ivanov, M and Krielj, A and otar, P and Zhou, Q and Ponti, J and Zhernovkov, V and Schneemilch, M and Doumandji, Z and Punik, M and Umek, P and Pajk, S and Joubert, O and Schmid, O and Urbani, I and Irmler, M and Beckers, J and Lobaskin, V and Halappanavar, S and Quirke, N and Lyubartsev, AP and Vogel, U and Kokli, T and Stoeger, T and trancar, J},
doi = {10.1002/adma.202003913},
journal = {Advanced Materials},
title = {Prediction of chronic inflammation for inhaled particles: the impact of material cycling and quarantining in the lung epithelium},
url = {http://dx.doi.org/10.1002/adma.202003913},
volume = {32},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - On a daily basis, people are exposed to a multitude of health-hazardous airborne particulate matter with notable deposition in the fragile alveolar region of the lungs. Hence, there is a great need for identification and prediction of material-associated diseases, currently hindered due to the lack of in-depth understanding of causal relationships, in particular between acute exposures and chronic symptoms. By applying advanced microscopies and omics to in vitro and in vivo systems, together with in silico molecular modeling, it is determined herein that the long-lasting response to a single exposure can originate from the interplay between the newly discovered nanomaterial quarantining and nanomaterial cycling between different lung cell types. This new insight finally allows prediction of the spectrum of lung inflammation associated with materials of interest using only in vitro measurements and in silico modeling, potentially relating outcomes to material properties for a large number of materials, and thus boosting safe-by-design-based material development. Because of its profound implications for animal-free predictive toxicology, this work paves the way to a more efficient and hazard-free introduction of numerous new advanced materials into our lives.
AU  - Kokot,H
AU  - Kokot,B
AU  - Sebastijanovi,A
AU  - Voss,C
AU  - Podlipec,R
AU  - Zawilska,P
AU  - Berthing,T
AU  - López,CB
AU  - Danielsen,PH
AU  - Contini,C
AU  - Ivanov,M
AU  - Krielj,A
AU  - otar,P
AU  - Zhou,Q
AU  - Ponti,J
AU  - Zhernovkov,V
AU  - Schneemilch,M
AU  - Doumandji,Z
AU  - Punik,M
AU  - Umek,P
AU  - Pajk,S
AU  - Joubert,O
AU  - Schmid,O
AU  - Urbani,I
AU  - Irmler,M
AU  - Beckers,J
AU  - Lobaskin,V
AU  - Halappanavar,S
AU  - Quirke,N
AU  - Lyubartsev,AP
AU  - Vogel,U
AU  - Kokli,T
AU  - Stoeger,T
AU  - trancar,J
DO  - 10.1002/adma.202003913
PY  - 2020///
SN  - 0935-9648
TI  - Prediction of chronic inflammation for inhaled particles: the impact of material cycling and quarantining in the lung epithelium
T2  - Advanced Materials
UR  - http://dx.doi.org/10.1002/adma.202003913
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33073368
UR  - http://hdl.handle.net/10044/1/84886
VL  - 32
ER  -
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