Imperial College London
Alternate

ProfessorNadiaRosenthal

Faculty of Medicine, National Heart & Lung Institute

Chair in Cardiovascular Science&ScientificDirector
 
 
 
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Contact

 

+44 (0)20 7594 2737n.rosenthal

 
 
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Location

 

424W2ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lavine:2018:10.1016/j.jacc.2018.08.2149,
author = {Lavine, KJ and Pinto, AR and Epelman, S and Kopecky, BJ and Clemente-Casares, X and Godwin, J and Rosenthal, N and Kovacic, JC},
doi = {10.1016/j.jacc.2018.08.2149},
journal = {Journal of the American College of Cardiology},
pages = {2213--2230},
title = {The macrophage in cardiac homeostasis and disease JACC macrophage in CVD series (Part 4)},
url = {http://dx.doi.org/10.1016/j.jacc.2018.08.2149},
volume = {72},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Macrophages are integral components of cardiac tissue and exert profound effects on the healthy and diseased heart. Paradigm shifting studies using advanced molecular techniques have revealed significant complexity within these macrophage populations that reside in the heart. In this final of a 4-part review series covering the macrophage in cardiovascular disease, the authors review the origins, dynamics, cell surface markers, and respective functions of each cardiac macrophage subset identified to date, including in the specific scenarios of myocarditis and after myocardial infarction. Looking ahead, a deeper understanding of the diverse and often dichotomous functions of cardiac macrophages will be essential for the development of targeted therapies to mitigate injury and orchestrate recovery of the diseased heart. Moreover, as macrophages are critical for cardiac healing, they are an emerging focus for therapeutic strategies aimed at minimizing cardiomyocyte death, ameliorating pathological cardiac remodeling, and for treating heart failure and after myocardial infarction.
AU  - Lavine,KJ
AU  - Pinto,AR
AU  - Epelman,S
AU  - Kopecky,BJ
AU  - Clemente-Casares,X
AU  - Godwin,J
AU  - Rosenthal,N
AU  - Kovacic,JC
DO  - 10.1016/j.jacc.2018.08.2149
EP  - 2230
PY  - 2018///
SN  - 0735-1097
SP  - 2213
TI  - The macrophage in cardiac homeostasis and disease JACC macrophage in CVD series (Part 4)
T2  - Journal of the American College of Cardiology
UR  - http://dx.doi.org/10.1016/j.jacc.2018.08.2149
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000448002900014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0735109718383049?via%3Dihub
VL  - 72
ER  -
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