Imperial College London
Alternate

ProfessorNadiaRosenthal

Faculty of Medicine, National Heart & Lung Institute

Chair in Cardiovascular Science&ScientificDirector
 
 
 
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Contact

 

+44 (0)20 7594 2737n.rosenthal

 
 
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Location

 

424W2ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Forte:2020:10.1016/j.celrep.2020.02.008,
author = {Forte, E and Skelly, DA and Chen, M and Daigle, S and Morelli, KA and Hon, O and Philip, VM and Costa, MW and Rosenthal, NA and Furtado, MB},
doi = {10.1016/j.celrep.2020.02.008},
journal = {Cell Reports},
pages = {3149--3163.e6},
title = {Dynamic interstitial cell response during myocardial infarction predicts resilience to rupture in genetically diverse mice},
url = {http://dx.doi.org/10.1016/j.celrep.2020.02.008},
volume = {30},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cardiac ischemia leads to the loss of myocardial tissue and the activation of a repair process that culminates in the formation of a scar whose structural characteristics dictate propensity to favorable healing or detrimental cardiac wall rupture. To elucidate the cellular processes underlying scar formation, here we perform unbiased single-cell mRNA sequencing of interstitial cells isolated from infarcted mouse hearts carrying a genetic tracer that labels epicardial-derived cells. Sixteen interstitial cell clusters are revealed, five of which were of epicardial origin. Focusing on stromal cells, we define 11 sub-clusters, including diverse cell states of epicardial- and endocardial-derived fibroblasts. Comparing transcript profiles from post-infarction hearts in C57BL/6J and 129S1/SvImJ inbred mice, which displays a marked divergence in the frequency of cardiac rupture, uncovers an early increase in activated myofibroblasts, enhanced collagen deposition, and persistent acute phase response in 129S1/SvImJ mouse hearts, defining a crucial time window of pathological remodeling that predicts disease outcome.
AU  - Forte,E
AU  - Skelly,DA
AU  - Chen,M
AU  - Daigle,S
AU  - Morelli,KA
AU  - Hon,O
AU  - Philip,VM
AU  - Costa,MW
AU  - Rosenthal,NA
AU  - Furtado,MB
DO  - 10.1016/j.celrep.2020.02.008
EP  - 3163
PY  - 2020///
SN  - 2211-1247
SP  - 3149
TI  - Dynamic interstitial cell response during myocardial infarction predicts resilience to rupture in genetically diverse mice
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2020.02.008
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000517773300024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S2211124720301625?via%3Dihub
UR  - http://hdl.handle.net/10044/1/82098
VL  - 30
ER  -
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