Imperial College London
Alternate

Professor Nilay Shah OBE FREng

Faculty of Engineering, Department of Chemical Engineering

Professor of Process Systems Engineering
 
 
 
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Contact

 

+44 (0)20 7594 6621n.shah

 
 
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Assistant

 

Miss Jessica Baldock +44 (0)20 7594 5699

 
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Location

 

ACEX 522ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kucherenko:2020:10.1016/j.compchemeng.2019.106608,
author = {Kucherenko, S and Giamalakis, D and Shah, N and García-Muñoz, S},
doi = {10.1016/j.compchemeng.2019.106608},
journal = {Computers & Chemical Engineering},
pages = {1--9},
title = {Computationally efficient identification of probabilistic design spaces through application of metamodeling and adaptive sampling},
url = {http://dx.doi.org/10.1016/j.compchemeng.2019.106608},
volume = {132},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The design space (DS) is defined as the combination of materials and process conditions which provides assurance of quality for a pharmaceutical product (e.g. purity, potency, uniformity). A model-based approach to identify a probability-based design space requires simulations across the entire process parameter space (certain) and the uncertain model parameter space and material properties space if explicitly considered by the model. This exercise is a demanding task. A novel theoretical and numerical framework for determining probabilistic DS using metamodelling and adaptive sampling is developed. Several approaches were proposed and tested among which the most efficient is a new multi-step adaptive technique based using a metamodel for a probability map as an acceptance-rejection criterion to optimize sampling to identify the DS. It is shown that application of metamodel-based filters can significantly reduce model complexity and computational costs with speed up of two orders of magnitude observed here.
AU  - Kucherenko,S
AU  - Giamalakis,D
AU  - Shah,N
AU  - García-Muñoz,S
DO  - 10.1016/j.compchemeng.2019.106608
EP  - 9
PY  - 2020///
SN  - 0098-1354
SP  - 1
TI  - Computationally efficient identification of probabilistic design spaces through application of metamodeling and adaptive sampling
T2  - Computers & Chemical Engineering
UR  - http://dx.doi.org/10.1016/j.compchemeng.2019.106608
UR  - https://www.sciencedirect.com/science/article/pii/S0098135419308877?via%3Dihub
UR  - http://hdl.handle.net/10044/1/74719
VL  - 132
ER  -
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