Imperial College London
Alternate

Professor Nilay Shah OBE FREng

Faculty of Engineering, Department of Chemical Engineering

Professor of Process Systems Engineering
 
 
 
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Contact

 

+44 (0)20 7594 6621n.shah

 
 
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Assistant

 

Miss Jessica Baldock +44 (0)20 7594 5699

 
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Location

 

ACEX 522ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Papathanasiou:2020:10.1038/s41417-019-0157-z,
author = {Papathanasiou, MM and Stamatis, C and Lakelin, M and Farid, S and Titchener-Hooker, N and Shah, N},
doi = {10.1038/s41417-019-0157-z},
journal = {Cancer Gene Therapy},
pages = {799--809},
title = {Autologous CAR T-cell therapies supply chain: challenges and opportunities?},
url = {http://dx.doi.org/10.1038/s41417-019-0157-z},
volume = {27},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chimeric antigen receptor (CAR) T cells are considered a potentially disruptive cancer therapy, showing highly promisingresults. Their recent success and regulatory approval (both in the USA and Europe) are likely to generate a rapidly increasingdemand and a need for the design of robust and scalable manufacturing and distribution models that will ensure timely andcost-effective delivery of the therapy to the patient. However, there are challenging tasks as these therapies are accompaniedby a series of constraints and particularities that need to be taken into consideration in the decision-making process. Here, wepresent an overview of the current state of the art in the CAR T cell market and present novel concepts that can debottleneckkey elements of the current supply chain model and, we believe, help this technology achieve its long-term potential.
AU  - Papathanasiou,MM
AU  - Stamatis,C
AU  - Lakelin,M
AU  - Farid,S
AU  - Titchener-Hooker,N
AU  - Shah,N
DO  - 10.1038/s41417-019-0157-z
EP  - 809
PY  - 2020///
SN  - 0929-1903
SP  - 799
TI  - Autologous CAR T-cell therapies supply chain: challenges and opportunities?
T2  - Cancer Gene Therapy
UR  - http://dx.doi.org/10.1038/s41417-019-0157-z
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000508143300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/76421
VL  - 27
ER  -
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