Imperial College London
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Professor Nicholas Simmonds

Faculty of Medicine, National Heart & Lung Institute

Professor of Practice (Respiratory Medicine)
 
 
 
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Contact

 

+44 (0)20 7351 8997n.simmonds

 
 
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Location

 

Dept of Cystic FibrosisRoyal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Archangelidi:2022:10.1016/j.jcf.2021.07.004,
author = {Archangelidi, O and Cullinan, P and Simmonds, NJ and Mentzakis, E and Peckham, D and Bilton, D and Carr, SB},
doi = {10.1016/j.jcf.2021.07.004},
journal = {Journal of Cystic Fibrosis},
pages = {302--308},
title = {Incidence and risk factors of cancer in individuals with cystic fibrosis in the UK; a case-control study.},
url = {http://dx.doi.org/10.1016/j.jcf.2021.07.004},
volume = {21},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - To assess cancer incidence in the UK cystic fibrosis (CF) population and determine the associated risk factors, we undertook a nested case-control study of patients with CF, registered with the UK CF Registry. Each case with a first reported cancer between 1999 and 2017 was matched with up to 4 controls: by age (±2-years) and year of cancer diagnosis. Conditional logistic regressions were adjusted for sex, lung function (FEV1%), CF related diabetes (CFRD), F508del status, transplant status, DIOS, gastro-oesophageal reflux disease, meconium ileus, Pseudomonas aeruginosa infection, pancreatic insufficiency, proton pump inhibitor (PPI) use, IV antibiotic days and BMI. Results: From 12,886 registered patients, 146 (1.1%) cases of malignancy were identified with 14.3% of cases occurring post solid organ transplant. Site of primary cancer was available for 98 patients: 22% were gastro-intestinal in origin (77% lower, 23% upper GI), 13% skin, 13% breast and 11% lymphomas/leukaemia. In univariable analysis, transplantation increased the odds of reporting any cancer by 2.46 times (95%CI: 1.3-4.6). CFRD also increased the odds of reporting any cancer (OR 2.35; CI: 1.37-4.0) and PPI use (OR 2.0; CI 1.28-3.19). In the multivariable models significant associations with CFRD and transplant remained, while PA infection, PPI use and being overweight showed increased, but statistically insignificant risks. The incidence of GI cancer was strongly associated with CFRD (OR=4.04; 1.47-11.1). Conclusions: We observed a high incidence of lower GI cancers in our cohort which was significantly affected by the presence of CFRD. Screening for gastrointestinal cancers could benefit patients at higher risk.
AU  - Archangelidi,O
AU  - Cullinan,P
AU  - Simmonds,NJ
AU  - Mentzakis,E
AU  - Peckham,D
AU  - Bilton,D
AU  - Carr,SB
DO  - 10.1016/j.jcf.2021.07.004
EP  - 308
PY  - 2022///
SN  - 1569-1993
SP  - 302
TI  - Incidence and risk factors of cancer in individuals with cystic fibrosis in the UK; a case-control study.
T2  - Journal of Cystic Fibrosis
UR  - http://dx.doi.org/10.1016/j.jcf.2021.07.004
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34348871
UR  - https://www.sciencedirect.com/science/article/pii/S1569199321013023?via%3Dihub
UR  - http://hdl.handle.net/10044/1/91441
VL  - 21
ER  -
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