Imperial College London
Portrait Picture

DrNathanSkene

Faculty of Medicine, Department of Brain Sciences

Lecturer in Dementia Research, UK DRI Group Leader
 
 
 
//

Contact

 

n.skene Website

 
 
//

Location

 

515Burlington DanesHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Zeisel:2018:10.1016/j.cell.2018.06.021,
author = {Zeisel, A and Hochgerner, H and Lönnerberg, P and Johnsson, A and Memic, F and van, der Zwan J and Häring, M and Braun, E and Borm, LE and La, Manno G and Codeluppi, S and Furlan, A and Lee, K and Skene, N and Harris, KD and Hjerling-Leffler, J and Arenas, E and Ernfors, P and Marklund, U and Linnarsson, S},
doi = {10.1016/j.cell.2018.06.021},
journal = {Cell},
pages = {999--1014.e22},
title = {Molecular architecture of the mouse nervous system},
url = {http://dx.doi.org/10.1016/j.cell.2018.06.021},
volume = {174},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The mammalian nervous system executes complex behaviors controlled by specialized, precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a million single cells to create a detailed census of cell types in the mouse nervous system. We mapped cell types spatially and derived a hierarchical, data-driven taxonomy. Neurons were the most diverse and were grouped by developmental anatomical units and by the expression of neurotransmitters and neuropeptides. Neuronal diversity was driven by genes encoding cell identity, synaptic connectivity, neurotransmission, and membrane conductance. We discovered seven distinct, regionally restricted astrocyte types that obeyed developmental boundaries and correlated with the spatial distribution of key glutamate and glycine neurotransmitters. In contrast, oligodendrocytes showed a loss of regional identity followed by a secondary diversification. The resource presented here lays a solid foundation for understanding the molecular architecture of the mammalian nervous system and enables genetic manipulation of specific cell types.
AU  - Zeisel,A
AU  - Hochgerner,H
AU  - Lönnerberg,P
AU  - Johnsson,A
AU  - Memic,F
AU  - van,der Zwan J
AU  - Häring,M
AU  - Braun,E
AU  - Borm,LE
AU  - La,Manno G
AU  - Codeluppi,S
AU  - Furlan,A
AU  - Lee,K
AU  - Skene,N
AU  - Harris,KD
AU  - Hjerling-Leffler,J
AU  - Arenas,E
AU  - Ernfors,P
AU  - Marklund,U
AU  - Linnarsson,S
DO  - 10.1016/j.cell.2018.06.021
EP  - 1014
PY  - 2018///
SN  - 0092-8674
SP  - 999
TI  - Molecular architecture of the mouse nervous system
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2018.06.021
UR  - http://hdl.handle.net/10044/1/67255
VL  - 174
ER  -
Download