Imperial College London
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DrNathanSkene

Faculty of Medicine, Department of Brain Sciences

Lecturer in Dementia Research, UK DRI Group Leader
 
 
 
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Contact

 

n.skene Website

 
 
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Location

 

515Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bryois:2020:10.1038/s41588-020-0610-9,
author = {Bryois, J and Skene, NG and Hansen, TF and Kogelman, LJA and Watson, HJ and Liu, Z and Eating, Disorders Working Group of the Psychiatric Genomics Consortium and International, Headache Genetics Consortium and 23andMe, Research Team and Brueggeman, L and Breen, G and Bulik, CM and Arenas, E and Hjerling-Leffler, J and Sullivan, PF},
doi = {10.1038/s41588-020-0610-9},
journal = {Nature Genetics},
pages = {482--493},
title = {Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease},
url = {http://dx.doi.org/10.1038/s41588-020-0610-9},
volume = {52},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson's disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson's disease.
AU  - Bryois,J
AU  - Skene,NG
AU  - Hansen,TF
AU  - Kogelman,LJA
AU  - Watson,HJ
AU  - Liu,Z
AU  - Eating,Disorders Working Group of the Psychiatric Genomics Consortium
AU  - International,Headache Genetics Consortium
AU  - 23andMe,Research Team
AU  - Brueggeman,L
AU  - Breen,G
AU  - Bulik,CM
AU  - Arenas,E
AU  - Hjerling-Leffler,J
AU  - Sullivan,PF
DO  - 10.1038/s41588-020-0610-9
EP  - 493
PY  - 2020///
SN  - 1061-4036
SP  - 482
TI  - Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/s41588-020-0610-9
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32341526
UR  - http://hdl.handle.net/10044/1/79090
VL  - 52
ER  -
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