Imperial College London


Faculty of MedicineDepartment of Brain Sciences

Senior Research Fellow



+44 (0)20 7594 5292n.syed




E506Burlington DanesHammersmith Campus






BibTex format

author = {Crighton, D and Wilkinson, S and O'Prey, J and Syed, N and Smith, P and Harrison, PR and Gasco, M and Garrone, O and Crook, T and Ryan, KM},
journal = {Cell},
title = {DRAM, a p53-induced modulator of autophagy, is critical for apoptosis},
volume = {126},
year = {2006}

RIS format (EndNote, RefMan)

AB - Inactivation of cell death is a major step in tumor development, and p53, a tumor suppressor frequently mutated in cancer, is a critical mediator of cell death. While a role for p53 in apoptosis is well established, direct links to other pathways controlling cell death are unknown. Here we describe DRAM (damage-regulated autophagy modulator), a p53 target gene encoding a lysosomal protein that induces macroautophagy, as an effector of p53-mediated death. We show that p53 induces autophagy in a DRAM-dependent manner and, while overexpression of DRAM alone causes minimal cell death, DRAM is essential for p53-mediated apoptosis. Moreover, analysis of DRAM in primary tumors revealed frequent decreased expression often accompanied by retention of wild-type p53. Collectively therefore, these studies not only report a stress-induced regulator of autophagy but also highlight the relationship of DRAM and autophagy to p53 function and damage-induced programmed cell death.
AU - Crighton,D
AU - Wilkinson,S
AU - O'Prey,J
AU - Syed,N
AU - Smith,P
AU - Harrison,PR
AU - Gasco,M
AU - Garrone,O
AU - Crook,T
AU - Ryan,KM
PY - 2006///
TI - DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
T2 - Cell
VL - 126
ER -