Imperial College London

DrNeloferSyed

Faculty of MedicineDepartment of Medicine

Senior Research Fellow
 
 
 
//

Contact

 

+44 (0)20 7594 5292n.syed

 
 
//

Location

 

E506Burlington DanesHammersmith Campus

//

Summary

 

Publications

Publication Type
Year
to

89 results found

Hajji N, García-Domínguez DJ, Hontecillas-Prieto L, O'Neill K, de Álava E, Syed Net al., 2018, The bitter side of epigenetics: variability and resistance to chemotherapy., Epigenomics

One of the major obstacles to the development of effective new cancer treatments and the main factor for the increasing number of clinical trial failures appears to be the paucity of accurate, reproducible and robust drug resistance testing methods. Most research assessing the resistance of cancers to chemotherapy has concentrated on genetic-based molecular mechanisms, while the role of epigenetics in drug resistance has been generally overlooked. This is rather surprising given that an increasing body of evidence pointing to the fact that epigenetic mechanism alterations appear to play a pivotal role in cancer initiation, progression and development of chemoresistance. This resulted in a series of clinical trials involving epi-drug as single treatment or combined with cancer conventional drugs. In this review, we provided the main mechanisms by which the epigenetic regulators control the resistance to cancer drugs.

JOURNAL ARTICLE

Moren L, Perryman R, Crook T, Langer JK, Oneill K, Syed N, Antti Het al., 2018, Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM, BMC CANCER, Vol: 18, ISSN: 1471-2407

JOURNAL ARTICLE

Moren L, Perryman R, Crook T, Langer JK, Oneill K, Syed N, Antti Het al., 2018, Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM (vol 18, 167, 2018), BMC CANCER, Vol: 18, ISSN: 1471-2407

JOURNAL ARTICLE

Bassiri K, Ferluga S, Sharma V, Syed N, Adams CL, Lasonder E, Hanemann COet al., 2017, Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target, EBIOMEDICINE, Vol: 16, Pages: 76-86, ISSN: 2352-3964

JOURNAL ARTICLE

Preston J, Stylianou J, Zeng Q, Glover S, Scheck AC, Woolf EC, O'Neill K, Syed Net al., 2017, THE KETOGENIC DIET INDUCES EPIGENETIC CHANGES THAT PLAY KEY ROLES IN TUMOUR DEVELOPMENT, Meeting of the British-Neuro-Oncology-Society (BNOS), Publisher: OXFORD UNIV PRESS INC, Pages: 128-128, ISSN: 1522-8517

CONFERENCE PAPER

Nevedomskaya E, Perryman R, Solanki S, Syed N, Mayboroda OA, Keun HCet al., 2016, A Systems Oncology Approach Identifies NT5E as a Key Metabolic Regulator in Tumor Cells and Modulator of Platinum Sensitivity, JOURNAL OF PROTEOME RESEARCH, Vol: 15, Pages: 280-290, ISSN: 1535-3893

JOURNAL ARTICLE

Renziehausen A, Eschbacher J, O'Neill K, Tzakos A, Crook T, Syed Net al., 2016, ANGIOTENSIN SIGNALLING IN GBM: AT2R AS A NOVEL THERAPEUTIC TARGET, 21st Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology, Publisher: OXFORD UNIV PRESS INC, Pages: 40-40, ISSN: 1522-8517

CONFERENCE PAPER

Woolf EC, Syed N, Scheck AC, 2016, Tumor Metabolism, the Ketogenic Diet and beta-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Theraphy, FRONTIERS IN MOLECULAR NEUROSCIENCE, Vol: 9, ISSN: 1662-5099

JOURNAL ARTICLE

Abaitua F, Przystal J, Hajitou A, Syed Net al., 2015, Arginine deprivation using ADI-PEG20 leads to regression of an ASS1-ve intracranial GBM tumor in mice and potentiates gamma irradiation of ASS1+ve GBM in vitro, 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472

CONFERENCE PAPER

Ingemarsdotter CK, Tookman LA, Browne A, Pirlo K, Cutts R, Chelela C, Khurrum KF, Leung EYL, Dowson S, Webber L, Khan I, Ennis D, Syed N, Crook TR, Brenton JD, Lockley M, McNeish IAet al., 2015, Paclitaxel resistance increases oncolytic adenovirus efficacy via upregulated CAR expression and dysfunctional cell cycle control, MOLECULAR ONCOLOGY, Vol: 9, Pages: 791-805, ISSN: 1574-7891

JOURNAL ARTICLE

Pazmandi J, O'Neill KS, Scheck AC, Szlosarek PW, Woolf EC, Brooks KS, Syed Net al., 2015, The ketogenic diet alters the expression of microRNAs that play key roles in tumor development, 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472

CONFERENCE PAPER

Yata T, Lee ELQ, Suwan K, Syed N, Asavarut P, Hajitou Aet al., 2015, Modulation of extracellular matrix in cancer is associated with enhanced tumor cell targeting by bacteriophage vectors, MOLECULAR CANCER, Vol: 14, ISSN: 1476-4598

JOURNAL ARTICLE

Abaitua F, Crook T, O'Neill K, Syed Net al., 2014, TARGETING COLLAGEN REGULATION IN GLIOBLASTOMA MULTIFORME, Meeting of the British-Neuro-Oncology-Society (BNOS), Publisher: OXFORD UNIV PRESS INC, ISSN: 1522-8517

CONFERENCE PAPER

Abaitua F, Crook T, O'Neill K, Syed Net al., 2014, TARGETING COLLAGEN REGULATION IN GLIOBLASTOMA MULTIFORME, NEURO-ONCOLOGY, Vol: 16, ISSN: 1522-8517

JOURNAL ARTICLE

Allen MD, Phuong L, Hudson C, Leyton J, Delage B, Ghazaly E, Cutts R, Yuan M, Syed N, Lo Nigro C, Lattanzio L, Chmielewska-Kassassir M, Tomlinson I, Roylance R, Whitaker HC, Warren AY, Neal D, Frezza C, Beltran L, Jones LJ, Chelala C, Wu B-W, Bomalaski JS, Jackson RC, Lu Y-J, Crook T, Lemoine NR, Mather S, Foster J, Sosabowski J, Avril N, Li C-F, Szlosarek PWet al., 2014, Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging, CANCER RESEARCH, Vol: 74, Pages: 896-907, ISSN: 0008-5472

JOURNAL ARTICLE

Asavarut P, O'Neill K, Syed N, Hajitou Aet al., 2014, Chimeric adeno-associated virus and bacteriophage: a potential targeted gene therapy vector for malignant glioma., Ther Deliv, Vol: 5, Pages: 975-990

The incipient development of gene therapy for cancer has fuelled its progression from bench to bedside in mere decades. Of all malignancies that exist, gliomas are the largest class of brain tumors, and are renowned for their aggressiveness and resistance to therapy. In order for gene therapy to achieve clinical success, a multitude of barriers ranging from glioma tumor physiology to vector biology must be overcome. Many viral gene delivery systems have been subjected to clinical investigation; however, with highly limited success. In this review, the current progress and challenges of gene therapy for malignant glioma are discussed. Moreover, we highlight the hybrid adeno-associated virus and bacteriophage vector as a potential candidate for targeted gene delivery to brain tumors.

JOURNAL ARTICLE

Channathodiyil P, Kardooni H, Khozoie C, Nelofer S, Darling J, Morris M, Warr Tet al., 2014, EPIGENETIC INACTIVATION OF ARGININE BIOSYNTHESIS PATHWAY IN PAEDIATRIC HIGH GRADE GLIOMA, NEURO-ONCOLOGY, Vol: 16, ISSN: 1522-8517

JOURNAL ARTICLE

Hatzimichael E, Syed N, Lo Nigro C, Rao B, Crook Tet al., 2014, How detection of epigenetic alterations of blood-borne DNA could improve melanoma diagnosis, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 14, Pages: 639-642, ISSN: 1473-7159

JOURNAL ARTICLE

Langer J, Elustondo FA, Chan ECY, Antti H, Want E, ONeill K, Syed Net al., 2014, METABOLOMIC ANALYSIS OF GLIOBLASTOMA MULTIFORME UPON ARGININE DEPRIVATION TREATMENT, NEURO-ONCOLOGY, Vol: 16, ISSN: 1522-8517

JOURNAL ARTICLE

Langer JK, Chan ECY, Antti H, Want E, ONeill K, Syed Net al., 2014, METABOLOMIC ANALYSIS OF GLIOBLASTOMA MULTIFORME UPON ARGININE DEPRIVATION TREATMENT, Meeting of the British-Neuro-Oncology-Society (BNOS), Publisher: OXFORD UNIV PRESS INC, ISSN: 1522-8517

CONFERENCE PAPER

Qiao B, Oneill K, Syed N, 2014, SCOTIN EXPRESSION AND SURVIVAL IN GBM, Meeting of the British-Neuro-Oncology-Society (BNOS), Publisher: OXFORD UNIV PRESS INC, ISSN: 1522-8517

CONFERENCE PAPER

Lo Nigro C, Wang H, McHugh A, Lattanzio L, Matin R, Harwood C, Syed N, Hatzimichael E, Briasoulis E, Merlano M, Evans A, Thompson A, Leigh I, Fleming C, Inman GJ, Proby C, Crook Tet al., 2013, Methylated Tissue Factor Pathway Inhibitor 2 (TFP12) DNA in Serum Is a Biomarker of Metastatic Melanoma, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 133, Pages: 1278-1285, ISSN: 0022-202X

JOURNAL ARTICLE

Przystal JM, Umukoro E, Stoneham CA, Yata T, O'Neill K, Syed N, Hajitou Aet al., 2013, Proteasome inhibition in cancer is associated with enhanced tumor targeting by the adeno-associated virus/phage, MOLECULAR ONCOLOGY, Vol: 7, Pages: 55-66, ISSN: 1574-7891

JOURNAL ARTICLE

Syed N, Langer J, Janczar K, Singh P, Lo Nigro C, Lattanzio L, Coley HM, Hatzimichael E, Bomalaski J, Szlosarek P, Awad M, O'Neil K, Roncaroli F, Crook Tet al., 2013, Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma, CELL DEATH & DISEASE, Vol: 4, ISSN: 2041-4889

JOURNAL ARTICLE

Cavicchioli F, Shia A, O'Leary K, Haley V, Palmieri C, Syed N, Crook T, Thompson AM, Lo Nigro C, Schmid Pet al., 2012, EPIGENETIC SILENCING OF ARGININO-SUCCINATE SYNTHASE (ASS1) DEFINES ARGININE DEPLETION THERAPY AS A NOVEL TREATMENT STRATEGY FOR BREAST CANCER, 37th Congress of the European-Society-for-Medical-Oncology (ESMO), Publisher: OXFORD UNIV PRESS, Pages: 532-533, ISSN: 0923-7534

CONFERENCE PAPER

Coley HM, Chivers P, Syed N, Crook Tet al., 2012, Methylated PLK2 predicts response to taxanes, CANCER RESEARCH, Vol: 72, ISSN: 0008-5472

JOURNAL ARTICLE

Coley HM, Hatzimichael E, Blagden S, McNeish I, Thompson A, Crook T, Syed Net al., 2012, Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in cancer, ONCOTARGET, Vol: 3, Pages: 78-83, ISSN: 1949-2553

JOURNAL ARTICLE

Delage B, Luong P, Maharaj L, O'Riain C, Syed N, Crook T, Hatzimichael E, Papoudou-Bai A, Mitchell TJ, Whittaker SJ, Cerio R, Gribben J, Lemoine N, Bomalaski J, Li C-F, Joel S, Fitzgibbon J, Chen L-T, Szlosarek PWet al., 2012, Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis, CELL DEATH & DISEASE, Vol: 3, ISSN: 2041-4889

JOURNAL ARTICLE

Hatzimichael E, Dasoula A, Syed N, Szlosarek PW, Dranitsaris G, Crook T, Briasoulis ECet al., 2012, Epigenetic inactivation to target the arginine biosynthetic pathway in multiple myeloma., 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X

CONFERENCE PAPER

Hatzimichael E, Lo Nigro C, Lattanzio L, Syed N, Shah R, Dasoula A, Janczar K, Vivenza D, Monteverde M, Merlano M, Papoudou-Bai A, Bai M, Schmid P, Stebbing J, Bower M, Dyer MJS, Karran LE, ElguetaKarstegl C, Farrell PJ, Thompson A, Briasoulis E, Crook Tet al., 2012, The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: 1423-1432, ISSN: 0007-0920

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00156737&limit=30&person=true