Imperial College London

DrNeloferSyed

Faculty of MedicineDepartment of Medicine

Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 5292n.syed

 
 
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Location

 

E506Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

102 results found

Chatziathanasiadou MV, Stylos EK, Giannopoulou E, Spyridaki M-H, Briasoulis E, Kalofonos HP, Crook T, Syed N, Sivolapenko GB, Tzakos AGet al., 2019, Development of a validated LC-MS/MS method for the in vitro and in vivo quantitation of sunitinib in glioblastoma cells and cancer patients., J Pharm Biomed Anal, Vol: 164, Pages: 690-697

Sunitinib is a multi-targeted tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumor and is currently being investigated against other forms of malignant tumors. Recently great interest has emerged for the application of sunitinib to glioblastoma treatment. In order to have a method with broad applicability it will be of importance to have access to a method that could be applied both in human plasma and cell uptake studies. No method has been reported thus far for the estimation of sunitinib uptake in glioma cells. We therefore set out to develop a method that could be applied for quantifying sunitinib in human plasma and in cell uptake studies. The method was validated and accredited according to ISO 17025:2005 guideline in human plasma and successfully applied to cancer patient plasma. Also, the method was effectively recruited to establish a protocol for the evaluation of sunitinib accumulation into M095K glioma cells. This method could significantly contribute to developmental phases in repurposing this drug in different cancer types.

JOURNAL ARTICLE

El Mubarak MA, Stylos EK, Chatziathanasiadou M, Danika C, Alexiou GA, Tsekeris P, Renziehausen A, Crook T, Syed N, Sivolapenko GB, Tzakos AGet al., 2019, Development and validation of simple step protein precipitation UHPLC-MS/MS methods for quantitation of temozolomide in cancer patient plasma samples, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 162, Pages: 164-170, ISSN: 0731-7085

JOURNAL ARTICLE

Przystal JM, Hajji N, Khozoie C, Renziehausen A, Zeng Q, Abaitua F, Hajitou A, Suwan K, Want E, Bomalaski J, Szlosarek P, O'Neill K, Crook T, Syed Net al., 2018, Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM, CELL DEATH & DISEASE, Vol: 9, ISSN: 2041-4889

JOURNAL ARTICLE

Atkinson A, Renziehausen A, Wang H, Lo Nigro C, Lattanzio L, Merlano M, Rao B, Weir L, Evans A, Matin R, Harwood C, Szlosarek P, Pickering JG, Fleming C, Sim VR, Li S, Vasta JT, Raines RT, Boniol M, Thompson A, Proby C, Crook T, Syed Net al., 2018, The collagen prolyl hydroxylases are bifunctional growth regulators in melanoma., J Invest Dermatol

Appropriate post-translational processing of collagen requires prolyl hydroxylation, catalyzed by the prolyl 3- (C-P3H) and prolyl 4- (C-P4H) hydroxylases is essential for normal cell function. Here we have investigated the expression, transcriptional regulation and function of the C-P3H and C-P4H families in melanoma. We show that the CP3H family exemplified by Leprel1 and Leprel2 are subject to methylation-dependent transcriptional silencing in primary and metastatic melanoma consistent with a tumour suppressor function. In contrast, although there is transcriptional silencing of P4HA3 in a sub-set of melanomas, the CP4H family members P4HA1, P4HA2 and P4HA3 are often over-expressed in melanoma, expression being prognostic of worse clinical outcomes. Consistent with tumour suppressor function, ectopic expression of Leprel1 and Leprel2 inhibits melanoma proliferation, whereas P4HA2 and P4HA3 increase proliferation and particularly invasiveness of melanoma cells. Pharmacological inhibition with multiple selective C-P4H inhibitors reduces proliferation and inhibits invasiveness of melanoma cells. Together, our data identify the C-P3H and C-P4H families as potentially important regulators of melanoma growth and invasiveness and suggest that selective inhibition of C-P4H is an attractive strategy to reduce the invasive properties of melanoma cells.

JOURNAL ARTICLE

Hajji N, García-Domínguez DJ, Hontecillas-Prieto L, O'Neill K, de Álava E, Syed Net al., 2018, The bitter side of epigenetics: variability and resistance to chemotherapy, Epigenomics, ISSN: 1750-1911

One of the major obstacles to the development of effective new cancer treatments and the main factor for the increasing number of clinical trial failures appears to be the paucity of accurate, reproducible and robust drug resistance testing methods. Most research assessing the resistance of cancers to chemotherapy has concentrated on genetic-based molecular mechanisms, while the role of epigenetics in drug resistance has been generally overlooked. This is rather surprising given that an increasing body of evidence pointing to the fact that epigenetic mechanism alterations appear to play a pivotal role in cancer initiation, progression and development of chemoresistance. This resulted in a series of clinical trials involving epi-drug as single treatment or combined with cancer conventional drugs. In this review, we provided the main mechanisms by which the epigenetic regulators control the resistance to cancer drugs.

JOURNAL ARTICLE

Moren L, Perryman R, Crook T, Langer JK, Oneill K, Syed N, Antti Het al., 2018, Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM (vol 18, 167, 2018), BMC CANCER, Vol: 18, ISSN: 1471-2407

JOURNAL ARTICLE

Moren L, Perryman R, Crook T, Langer JK, Oneill K, Syed N, Antti Het al., 2018, Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM, BMC CANCER, Vol: 18, ISSN: 1471-2407

JOURNAL ARTICLE

Lo Nigro C, Renziehausen A, Tzakos AG, Wang H, Rao B, Matin R, Harwood C, Vivenza D, Tonissi F, Occelli M, Weir L, Li S, Sim VR, O'Neill K, Evans A, Thompson A, Szlosarek P, Fleming C, Proby C, Syed N, Merlano M, Crook Tet al., 2018, The renin angiotensin system (RAS) mediates bifunctional growth regulation in melanoma and is a target for therapeutic manipulation, Publisher: BIOMED CENTRAL LTD, ISSN: 1479-5876

CONFERENCE PAPER

Williams M, Cross H, Jenkinson MD, Martin K, Wood S, Scheck AC, Syed N, O'Neill K, Sheen K, Zabilowicz C, Breen K, Oliver K, Williams E, Johnson M, Fulcher Wet al., 2018, THE KETOGENIC DIET FOR PATIENTS WITH BRAIN TUMOURS: TWO PARALLEL RANDOMISED TRIALS, Meeting of the British-Neuro-Oncology-Society (BNOS), Publisher: OXFORD UNIV PRESS INC, Pages: 7-8, ISSN: 1522-8517

CONFERENCE PAPER

Pankratova S, Klingelhofer J, Dmytriyeva O, Owczarek S, Renziehausen A, Syed N, Porter AE, Dexter DT, Kiryushko Det al., 2018, The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival, THERANOSTICS, Vol: 8, Pages: 3977-3990, ISSN: 1838-7640

JOURNAL ARTICLE

Woolf EC, Bhattacharya A, Rossi AP, Davidson MM, Syed N, Scheck ACet al., 2017, THE KETONE BODY beta-HYDROXYBUTYRATE CHEMO- AND RADIO-SENSITIZES MALIGNANT GLIOMA CELLS BY INHIBITING HISTONE DEACETYLASE ACTIVITY AND DOWNREGULATING EXPRESSION OF RAD51, Joint Conference of 22nd Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology / Conference of the Society-for-CNS-Interstitial-Delivery-of-the-Therapeutics (SCIDOT) on Therapeutic Delivery to the CNS, Publisher: OXFORD UNIV PRESS INC, Pages: 83-83, ISSN: 1522-8517

CONFERENCE PAPER

Tzouliana S, Hajji N, Perryman R, O'Neill K, Woolf EC, Scheck AC, Syed Net al., 2017, THE KETOGENIC DIET ALTERS THE EPIGENETIC LANDSCAPE OF GBM TO POTENTIATE THE EFFECTS OF CHEMO AND RADIOTHERAPY, Joint Conference of 22nd Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology / Conference of the Society-for-CNS-Interstitial-Delivery-of-the-Therapeutics (SCIDOT) on Therapeutic Delivery to the CNS, Publisher: OXFORD UNIV PRESS INC, Pages: 96-97, ISSN: 1522-8517

CONFERENCE PAPER

Bassiri K, Ferluga S, Sharma V, Syed N, Adams CL, Lasonder E, Hanemann COet al., 2017, Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target, EBIOMEDICINE, Vol: 16, Pages: 76-86, ISSN: 2352-3964

JOURNAL ARTICLE

Preston J, Stylianou J, Zeng Q, Glover S, Scheck AC, Woolf EC, O'Neill K, Syed Net al., 2017, THE KETOGENIC DIET INDUCES EPIGENETIC CHANGES THAT PLAY KEY ROLES IN TUMOUR DEVELOPMENT, Meeting of the British-Neuro-Oncology-Society (BNOS), Publisher: OXFORD UNIV PRESS INC, Pages: 128-128, ISSN: 1522-8517

CONFERENCE PAPER

Woolf EC, Syed N, Scheck AC, 2016, Tumor Metabolism, the Ketogenic Diet and beta-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Theraphy, FRONTIERS IN MOLECULAR NEUROSCIENCE, Vol: 9, ISSN: 1662-5099

JOURNAL ARTICLE

Renziehausen A, Eschbacher J, O'Neill K, Tzakos A, Crook T, Syed Net al., 2016, ANGIOTENSIN SIGNALLING IN GBM: AT2R AS A NOVEL THERAPEUTIC TARGET, 21st Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology, Publisher: OXFORD UNIV PRESS INC, Pages: 40-40, ISSN: 1522-8517

CONFERENCE PAPER

Woolf EC, Rossi AP, Silva-Nichols HB, Gardner KD, Syed N, Scheck ACet al., 2016, THE KETONE BODY beta-HYDROXYBUTYRATE INHIBITS HISTONE DEACETYLASE ACTIVITY AND ALTERS EXPRESSION OF DNA REPAIR PROTEINS IN MALIGNANT GLIOMA CELLS, 21st Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology, Publisher: OXFORD UNIV PRESS INC, Pages: 62-63, ISSN: 1522-8517

CONFERENCE PAPER

Perryman R, O'Neill K, Keun H, Syed Net al., 2016, DETERMINING THE ROLE OF NICOTINAMIDE METABOLISM IN CHEMOSENSITIVITY IN GLIOBLASTOMA MULTIFORME, 21st Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology, Publisher: OXFORD UNIV PRESS INC, Pages: 36-36, ISSN: 1522-8517

CONFERENCE PAPER

Lo Nigro C, Lattanzio L, Wang H, Proby C, Syed N, Occelli M, Cauchi C, Merlano M, Harwood C, Thompson A, Crook Tet al., 2016, Prolyl 4-(C-P4H) hydroxylases have opposing effects in malignant melanoma: implication in prognosis and therapy, Publisher: BMC, ISSN: 1479-5876

CONFERENCE PAPER

Nevedomskaya E, Perryman R, Solanki S, Syed N, Mayboroda OA, Keun HCet al., 2016, A Systems Oncology Approach Identifies NT5E as a Key Metabolic Regulator in Tumor Cells and Modulator of Platinum Sensitivity, JOURNAL OF PROTEOME RESEARCH, Vol: 15, Pages: 280-290, ISSN: 1535-3893

JOURNAL ARTICLE

Pazmandi J, O'Neill KS, Scheck AC, Szlosarek PW, Woolf EC, Brooks KS, Syed Net al., 2015, The ketogenic diet alters the expression of microRNAs that play key roles in tumor development, 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472

CONFERENCE PAPER

Abaitua F, Przystal J, Hajitou A, Syed Net al., 2015, Arginine deprivation using ADI-PEG20 leads to regression of an ASS1-ve intracranial GBM tumor in mice and potentiates gamma irradiation of ASS1+ve GBM in vitro, 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472

CONFERENCE PAPER

Yata T, Lee ELQ, Suwan K, Syed N, Asavarut P, Hajitou Aet al., 2015, Modulation of extracellular matrix in cancer is associated with enhanced tumor cell targeting by bacteriophage vectors, MOLECULAR CANCER, Vol: 14, ISSN: 1476-4598

JOURNAL ARTICLE

Ingemarsdotter CK, Tookman LA, Browne A, Pirlo K, Cutts R, Chelela C, Khurrum KF, Leung EYL, Dowson S, Webber L, Khan I, Ennis D, Syed N, Crook TR, Brenton JD, Lockley M, McNeish IAet al., 2015, Paclitaxel resistance increases oncolytic adenovirus efficacy via upregulated CAR expression and dysfunctional cell cycle control, MOLECULAR ONCOLOGY, Vol: 9, Pages: 791-805, ISSN: 1574-7891

JOURNAL ARTICLE

Channathodiyil P, Kardooni H, Khozoie C, Nelofer S, Darling J, Morris M, Warr Tet al., 2014, EPIGENETIC INACTIVATION OF ARGININE BIOSYNTHESIS PATHWAY IN PAEDIATRIC HIGH GRADE GLIOMA, NEURO-ONCOLOGY, Vol: 16, ISSN: 1522-8517

JOURNAL ARTICLE

Abaitua F, Crook T, O'Neill K, Syed Net al., 2014, TARGETING COLLAGEN REGULATION IN GLIOBLASTOMA MULTIFORME, NEURO-ONCOLOGY, Vol: 16, ISSN: 1522-8517

JOURNAL ARTICLE

Langer J, Elustondo FA, Chan ECY, Antti H, Want E, ONeill K, Syed Net al., 2014, METABOLOMIC ANALYSIS OF GLIOBLASTOMA MULTIFORME UPON ARGININE DEPRIVATION TREATMENT, NEURO-ONCOLOGY, Vol: 16, ISSN: 1522-8517

JOURNAL ARTICLE

Langer JK, Chan ECY, Antti H, Want E, ONeill K, Syed Net al., 2014, METABOLOMIC ANALYSIS OF GLIOBLASTOMA MULTIFORME UPON ARGININE DEPRIVATION TREATMENT, Meeting of the British-Neuro-Oncology-Society (BNOS), Publisher: OXFORD UNIV PRESS INC, ISSN: 1522-8517

CONFERENCE PAPER

Qiao B, Oneill K, Syed N, 2014, SCOTIN EXPRESSION AND SURVIVAL IN GBM, Meeting of the British-Neuro-Oncology-Society (BNOS), Publisher: OXFORD UNIV PRESS INC, ISSN: 1522-8517

CONFERENCE PAPER

Abaitua F, Crook T, O'Neill K, Syed Net al., 2014, TARGETING COLLAGEN REGULATION IN GLIOBLASTOMA MULTIFORME, Meeting of the British-Neuro-Oncology-Society (BNOS), Publisher: OXFORD UNIV PRESS INC, ISSN: 1522-8517

CONFERENCE PAPER

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