Imperial College London
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DrNikhilVergis

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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n.vergis

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Parker:2019:10.1016/j.ebiom.2019.03.046,
author = {Parker, R and Kim, SJ and Im, GY and Nahas, J and Dhesi, B and Vergis, N and Sinha, A and Ghezzi, A and Rink, MR and McCune, A and Aithal, GP and Newsome, PN and Weston, CJ and Holt, A and Gao, B},
doi = {10.1016/j.ebiom.2019.03.046},
journal = {EBioMedicine},
pages = {511--518},
title = {Obesity in acute alcoholic hepatitis increases morbidity and mortality},
url = {http://dx.doi.org/10.1016/j.ebiom.2019.03.046},
volume = {45},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundAlcohol and obesity synergise to increase the risk of liver-related mortality. We examined the influence of adiposity on clinical outcomes in alcoholic hepatitis (AH) and the underlying inflammatory crosstalk between adipose tissue (AT) and the liver.MethodsA cohort of 233 patients with AH from the UK and USA provided data to analyse the effects of obesity in AH. Body mass index was corrected for the severity of ascites, termed cBMI. Inflammatory and metabolic profiling was undertaken by proteome analysis of human serum samples. The effect of alcohol on adipose tissue and CXCL11 expression was studied in 3T3-derived adipocytes and in mice using the high-fat diet-plus-binge ethanol model.FindingsObesity was common amongst patients with AH, seen in 19% of individuals. Obesity (HR 2.22, 95%CI 1.1–4.3, p=.022) and underweight (HR 2.38, 1.00–5.6, p=.049) were independently associated with mortality at 3months. Proteome analysis demonstrated multiple metabolic and inflammatory factors differentially expressed in obese AH verse lean AH, with CXCL11 being the most elevated factor in obese AH. In vitro analysis of cultured adipocytes and in vivo analysis of mouse models showed that alcohol induced CXCL11 expression in AT, but not in liver.InterpretationObesity is common in AH and associated with a greater than two-fold increase in short-term mortality. Obese AH is associated with a different inflammatory phenotype, with the greatest elevation in CXCL11. These data confirm that adiposity is clinically important in acute alcohol-related liver disease and illustrate the adipose-liver inflammatory axis in AH.FundThis work was supported in part by an EASL Sheila Sherlock Physician Scientist Fellowship. The funder played no role in gathering or analysing data or writing the manuscript. This paper presents independent research supported by the NIHR Birmingham Biomedical Research Centre at the University Hospitals Birmingham NHS Foundation Trust and the U
AU  - Parker,R
AU  - Kim,SJ
AU  - Im,GY
AU  - Nahas,J
AU  - Dhesi,B
AU  - Vergis,N
AU  - Sinha,A
AU  - Ghezzi,A
AU  - Rink,MR
AU  - McCune,A
AU  - Aithal,GP
AU  - Newsome,PN
AU  - Weston,CJ
AU  - Holt,A
AU  - Gao,B
DO  - 10.1016/j.ebiom.2019.03.046
EP  - 518
PY  - 2019///
SN  - 2352-3964
SP  - 511
TI  - Obesity in acute alcoholic hepatitis increases morbidity and mortality
T2  - EBioMedicine
UR  - http://dx.doi.org/10.1016/j.ebiom.2019.03.046
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000475860000051&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S2352396419301914?via%3Dihub
UR  - http://hdl.handle.net/10044/1/83919
VL  - 45
ER  -
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