Imperial College London
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DrNikhilVergis

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

n.vergis

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Middleton:2021:10.1177/17562848211031394,
author = {Middleton, P and Vergis, N},
doi = {10.1177/17562848211031394},
journal = {Therapeutic Advances in Gastroenterology},
pages = {1--19},
title = {Mitochondrial dysfunction and liver disease: role, relevance, and potential for therapeutic modulation},
url = {http://dx.doi.org/10.1177/17562848211031394},
volume = {14},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mitochondria are key organelles involved in energy production as well as numerous metabolic processes. There is a growing interest in the role of mitochondrial dysfunction in the pathogenesis of common chronic diseases as well as in cancer development. This review will examine the role mitochondria play in the pathophysiology of common liver diseases, including alcohol-related liver disease, non-alcoholic fatty liver disease, chronic hepatitis B and hepatocellular carcinoma. Mitochondrial dysfunction is described widely in the literature in studies examining patient tissue and in disease models. Despite significant differences in pathophysiology between chronic liver diseases, common mitochondrial defects are described, including increased mitochondrial reactive oxygen species production and impaired oxidative phosphorylation. We review the current literature on mitochondrial-targeted therapies, which have the potential to open new therapeutic avenues in the management of patients with chronic liver disease.
AU  - Middleton,P
AU  - Vergis,N
DO  - 10.1177/17562848211031394
EP  - 19
PY  - 2021///
SN  - 1756-2848
SP  - 1
TI  - Mitochondrial dysfunction and liver disease: role, relevance, and potential for therapeutic modulation
T2  - Therapeutic Advances in Gastroenterology
UR  - http://dx.doi.org/10.1177/17562848211031394
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000687999700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.sagepub.com/doi/10.1177/17562848211031394
UR  - http://hdl.handle.net/10044/1/92036
VL  - 14
ER  -
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