Publications
123 results found
Liu D, Wood NB, Xu XY, et al., 2009, Image-based Blood Flow Simulation in the Retinal Circulation, 4th European Conference of the International Federation for Medical and Biological Engineering (ECIFMBE), Publisher: SPRINGER, Pages: 1963-1966, ISSN: 1680-0737
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- Citations: 1
Soloperto G, Keenan N, Sheppard M, et al., 2009, PLAQUE RUPTURE IN THE CAROTID ARTERY: A COMBINED IMAGING, COMPUTATIONAL AND HISTOLOGICAL ANALYSIS, ASME Summer Bioengineering Conference, Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 1075-1076
Liu D, Wood NB, Xu XY, et al., 2009, 3D Reconstruction of the Retinal Arterial Tree Using Subject-Specific Fundus Images, 1st ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing, Publisher: SPRINGER, Pages: 187-+
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- Citations: 6
Tan FPP, Torii R, Borghi A, et al., 2009, Fluid-structure interaction analysis of wall stress and flow patterns in a thoracic aortic aneurysm, International Journal of Applied Mechanics, Vol: 1, Pages: 179-199
In this study, fluid-structure interaction (FSI) simulation was carried out to predict wall shear stress (WSS) and blood flow patterns in a thoracic aortic aneurysm (TAA) where haemodynamic stresses on the diseased aortic wall are thought to lead to the growth, progression and rupture of the aneurysm. Based on MR images, a patient-specific TAA model was reconstructed. A newly developed two-equation laminar-turbulent transitional model was employed and realistic velocity and pressure waveforms were used as boundary conditions. Analysis of results include turbulence intensity, wall displacement, WSS, wall tensile stress and comparison of velocity profiles between MRI data, rigid and FSI simulations. Velocity profiles demonstrated that the FSI simulation gave better agreement with the MRI data while results for the time-averaged WSS (TAWSS) and oscillatory shear index (OSI) distributions showed no qualitative differences between the simulations. With the FSI model, the maximum TAWSS value was 13% lower, whereas the turbulence intensity was significantly higher than the rigid model. The FSI simulation also provided results for wall mechanical stress in terms of von Mises stress, allowing regions of high wall stress to be identified.
Tan FPP, Soloperto G, Bashford S, et al., 2008, Analysis of Flow Disturbance in a Stenosed Carotid Artery Bifurcation Using Two-Equation Transitional and Turbulence Models, Journal of Biomechanical Engineering, Vol: 130, Pages: 061008-1-061-008-12
In this study, newly developed two-equation turbulence models and transitional variants are employed for the prediction of blood flow patterns in a diseased carotid artery where the growth, progression, and structure of the plaque at rupture are closely linked to low and oscillating wall shear stresses. Moreover, the laminar-turbulent transition in the poststenotic zone can alter the separation zone length, wall shear stress, and pressure distribution over the plaque, with potential implications for stresses within the plaque. Following the validation with well established experimental measurements and numerical studies, a magnetic-resonance (MR) image-based model of the carotid bifurcation with 70% stenosis was reconstructed and simulated using realistic patient-specific conditions. Laminar flow, a correlation-based transitional version of Menter's hybrid k-/k- shear stress transport (SST) model and its “scale adaptive simulation” (SAS) variant were implemented in pulsatile simulations from which analyses of velocity profiles, wall shear stress, and turbulence intensity were conducted. In general, the transitional version of SST and its SAS variant are shown to give a better overall agreement than their standard counterparts with experimental data for pulsatile flow in an axisymmetric stenosed tube. For the patient-specific case reported, the wall shear stress analysis showed discernable differences between the laminar flow and SST transitional models but virtually no difference between the SST transitional model and its SAS variant.
Torii R, Wood NB, Hadjiloizou N, et al., 2008, Differences in coronary artery haemodynamics due to changes in flow and vascular geometry after percutaneous coronary intervention, 13th Annual Meeting of the European-Council-for-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 762-762, ISSN: 0194-911X
Torii R, Wood NB, Hadjiloizou N, et al., 2008, Differences in coronary artery haemodynamics due to changes in flow and vascular geometry after percutaneous coronary intervention, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A1-A2, ISSN: 1355-6037
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- Citations: 2
Sun N, Wood NB, Xu XY, 2008, Computational modelling of mass transport in large arteries, Recent Advances in Modelling and Simulation, Editors: Petrone, Cammarata, Vienna, Austria, Publisher: I-Tech Education and Publishing, Pages: 555-580
Downie SP, Raynor SM, Firmin DN, et al., 2008, Effects of elastic compression stockings on wall shear stress in deep and superficial veins of the calf, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 294, Pages: H2112-H2120, ISSN: 0363-6135
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- Citations: 36
Borghi A, Wood NB, Mohiaddin RH, et al., 2008, Fluid-solid interaction simulation of flow and stress pattern in thoracoabdominal aneurysms: A patient-specific study, JOURNAL OF FLUIDS AND STRUCTURES, Vol: 24, Pages: 270-280, ISSN: 0889-9746
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- Citations: 59
Tan FPP, Soloperto G, Wood NB, et al., 2008, Advanced computational models for disturbed and turbulent flow in stenosed human carotid artery bifurcation, IFMBE Proceedings, Vol: 21 IFMBE, Pages: 390-394, ISSN: 1680-0737
In this study, newly developed two-equation transitional and turbulence models are employed for the prediction of blood flow patterns in diseased carotid artery where the growth, progression and structure of plaque at rupture are closely linked to low and oscillating wall shear stresses. Moreover, laminar-turbulent transition in the post-stenotic zone can alter the separation zone length, wall shear stress and pressure distribution over the plaque, with potential implications for stresses within the plaque. A separate validation study was carried out with well established experimental measurements and numerical studies. Laminar flow, Menter's hybrid k-ε/k-ω Shear Stress Transport model and its transitional version were implemented in pulsatile simulations from which analyses of velocity profiles, wall shear stress and turbulence intensity were conducted. It was found that the transitional version of SST gave better overall agreement with experimental data for pulsatile flow in an axisymmetric stenosed tube and this is further highlighted in the patient-specific geometry simulation results. A magnetic-resonance (MR) image based model of the carotid bifurcation with 70% stenosis was reconstructed and simulated using patient-specific boundary conditions. The laminar flow assumption was found to be inadequate when the differences occurred in the wall shear stress analysis of the patient-derived model. © 2008 Springer-Verlag.
Liu D, Wood NB, Xu XY, et al., 2008, 3D reconstruction of the retinal arterial tree based on fundus images using a self-calibration approach, 1st ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing, Publisher: TAYLOR & FRANCIS LTD, Pages: 307-+
Tan FPP, Borghi A, Mohiaddin RH, et al., 2008, Analysis of flow patterns in a patient-specific thoracic aortic aneurysm model, Computers and Structures, Pages: 1-11
Xu XY, Leung JH, Borghi A, et al., 2008, Subject-specific analysis of biomechanical forces in aortic aneurysms, Aortic Aneurysms: New insights into an old problem, Editors: Sakalihasan, Kuivaniemi, Michel, Liège, Publisher: Les Éditions De l’Université de Liège
Tan FPP, Soloperto G, Wood NB, et al., 2008, Advanced Computational Models for Disturbed and Turbulent Flow in Stenosed Human Carotid Artery Bifurcation, 4th Kuala Lumpur International Conference on Biomedical Engineering, Publisher: SPRINGER, Pages: 390-+, ISSN: 1680-0737
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- Citations: 4
Sun N, Wood NB, Hughes AD, et al., 2007, Influence of pulsatile flow on LDL transport in the arterial wall, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 35, Pages: 1782-1790, ISSN: 0090-6964
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- Citations: 30
Downie SP, Firmin DN, Wood NB, et al., 2007, Role of MRI in investigating the effects of elastic compression stockings on the deformation of the superficial and deep veins in the lower leg, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 26, Pages: 80-85, ISSN: 1053-1807
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- Citations: 20
Sun N, Wood NB, Hughes AD, et al., 2007, Effects of transmural pressure and wall shear stress on LDL accumulation in the arterial wall: a numerical study using a multilayered model, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 292, Pages: H3148-H3157, ISSN: 0363-6135
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- Citations: 51
Xu X Y, Wood N B, 2007, The Proximal Carotid Arteries – Image-Based Computational Modelling., Carotid Disease: The Role of Imaging in Diagnosis and Management, Editors: Gillard, Graves, Hatsukami, Yuan, Cambridge, UK, Publisher: Cambridge University Press, Pages: 312-322, ISBN: 9780521862264
Torii R, Wood NB, Hughes AD, et al., 2007, A computational study on the influence of catheter-delivered intravascular probes on blood flow in a coronary artery model, JOURNAL OF BIOMECHANICS, Vol: 40, Pages: 2501-2509, ISSN: 0021-9290
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- Citations: 20
XY Xu, NB Wood, 2007, The proximal carotid arteries – image-based computational modelling, Carotid Disease: The Role of Imaging in Diagnosis and Management, Editors: Gillard, Graves, Hatsukami, Yuan, Cambridge, Publisher: Cambridge University Press, Pages: 313-323, ISBN: 9780521862264
Torii R, Wood NB, Hadjiloizou N, et al., 2007, Does the difference in realistic waveform before and after stenting affect hemodynamics in stenosed coronary artery?, ASME Summer Bioengineering Conference, Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 467-468
Borghi A, Wood NB, Mohiaddin RH, et al., 2007, Fluid-solid interaction simulation of flow and stress pattern in thoracoabdominal aneurysms: A patient specific study, 6th Symposium on Fluid-Structure Interactions, Aeroelasticity and Flow-Induced Vibration and Noise, Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 671-675
Jackson M, Wood NB, Zhao S, et al., 2007, The effects of wall shear stress on intima-media hyperplasia in femoral bypass grafts, Rotterdam, Second Symposium on Biomechanics in Cardiovascular Disease: Shear Stress in Vascular Biology, Publisher: Erasmus Medical Centre
Sun N, Torii R, Wood NB, et al., 2007, Numerical simulation of blood-wall albumin transport in a realistic human right coronary artery, ASME Summer Bioengineering Conference, Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 107-108
Borghi A, Wood NB, Mohiaddin RH, et al., 2006, 3D geometric reconstruction of thoracic aortic aneurysms, BIOMEDICAL ENGINEERING ONLINE, Vol: 5, ISSN: 1475-925X
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- Citations: 15
Wood NB, Zhao SZ, Zambanini A, et al., 2006, Curvature and tortuosity of the superficial femoral artery: a possible risk factor for peripheral arterial disease, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 101, Pages: 1412-1418, ISSN: 8750-7587
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- Citations: 104
Sun N, Wood NB, Hughes AD, et al., 2006, Fluid-wall modelling of mass transfer in an axisymmetric stenosis: Effects of shear-dependent transport properties, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 34, Pages: 1119-1128, ISSN: 0090-6964
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- Citations: 81
Wood N B, Xu X Y, 2006, Modelling of haemodynamics in the cardiovascular system by integrating medical imaging techniques and computer modelling tools., Multidisciplinary Approaches to Theory in Medicine., Editors: Paton, McNamara, Paton, McNamara, Amsterdam, The Netherlands, Publisher: Elsevier B V, Pages: 325-351, ISBN: 9780444518064
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