Publications
536 results found
Zhang Y, Frampton AE, Cohen P, et al., 2012, Tumor Infiltration in the Medial Resection Margin Predicts Survival After Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma, JOURNAL OF GASTROINTESTINAL SURGERY, Vol: 16, Pages: 1875-1882, ISSN: 1091-255X
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- Citations: 47
Itoi T, Isayama H, Sofuni A, et al., 2012, Evaluation of effects of a novel endoscopically applied radiofrequency ablation biliary catheter using an ex-vivo pig liver, JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Vol: 19, Pages: 543-547, ISSN: 1868-6974
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- Citations: 49
Zerizer I, Al-Nahhas A, Towey D, et al., 2012, The role of early <SUP>18</SUP>F-FDG PET/CT in prediction of progression-free survival after <SUP>90</SUP>Y radioembolization: comparison with RECIST and tumour density criteria, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 39, Pages: 1391-1399, ISSN: 1619-7070
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- Citations: 72
Acharya M, Panagiotopoulos N, Bhaskaran P, et al., 2012, Laparoscopic resection of a giant exophytic liver haemangioma with the laparoscopic Habib 4× radiofrequency device., World J Gastrointest Surg, Vol: 4, Pages: 199-202, ISSN: 1948-9366
Haemangiomas are the most common solitary benign neoplasm of the liver with an incidence ranging from 5% to 20%. Although usually small and asymptomatic, they may reach considerable proportions and rarely give rise to life-threatening complications. Surgical intervention is required for incapacitating symptoms, established complications, and diagnostic uncertainty. The resection of haemangiomas demands meticulous surgical technique, owing to their high vascularity and the concomitant risk of intra-operative haemorrhage. Laparoscopic resection of giant haemangiomas is even more challenging, and has only been reported twice. We here report the case of a giant 10 cm liver haemangioma which was successfully resected laparoscopically using the laparoscopic HabibTM 4×, a bipolar radiofrequency device, without clamping major vessels and with minimal blood loss. Transfusion of blood or blood products was not required. The patient had an uneventful recovery and was asymptomatic at 7-mo follow-up.
Voutila J, Sætrom P, Mintz P, et al., 2012, Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells, Molecular Therapy - Nucleic Acids, Vol: 1, ISSN: 2162-2531
It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells. Using bioinformatics analysis and functional screening, we screened short-activating RNA (saRNA) oligonucleotides designed to target the promoter regions of the pluripotency reprogramming factors, Kruppel-like factor 4 (KLF4) and c-MYC. We identified KLF4 and c-MYC promoter-targeted saRNA sequences that consistently induced increases in their respective levels of nascent mRNA and protein expression in a time- and dose-dependent manner, as compared with scrambled sequence control oligonucleotides. The functional consequences of saRNA-induced activation of each targeted reprogramming factor were then characterized by comprehensively profiling changes in gene expression by microarray analysis, which revealed significant increases in mRNA levels of their respective downstream pathway genes. Notably, the microarray profile after saRNA-mediated induction of endogenous KLF4 and c-MYC showed similar gene expression patterns for stem cell- and cell cycle-related genes as compared with lentiviral vector-mediated overexpression of exogenous KLF4 and c-MYC transgenes, while divergent gene expression patterns common to viral vector-mediated transgene delivery were also noted. The use of promoter-targeted saRNAs for the activation of pluripotency reprogramming factors could have broad implications for stem cell research.
Mizandari M, Ao G, Zhang Y, et al., 2012, Novel Percutaneous Radiofrequency Ablation of Portal Vein Tumor Thrombus: Safety and Feasibility, Cardiovasc Intervent Radiol.
Zacharoulis D, Lazoura O, Rountas C, et al., 2012, A New Endovascular Radiofrequency Device for Dilatation of Vascular Stenosis in a Rabbit Model, JOURNAL OF INVESTIGATIVE SURGERY, Vol: 25, Pages: 253-261, ISSN: 0894-1939
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- Citations: 3
Zhang Y, Frampton AE, Kyriakides C, et al., 2012, Loco-recurrence after resection for ductal adenocarcinoma of the pancreas: predictors and implications for adjuvant chemoradiotherapy, JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol: 138, Pages: 1063-1071, ISSN: 0171-5216
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- Citations: 48
Thwaites JW, Reebye V, Mintz P, et al., 2012, Cellular replacement and regenerative medicine therapies in ischemic stroke, REGENERATIVE MEDICINE, Vol: 7, Pages: 387-395, ISSN: 1746-0751
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- Citations: 19
Thwaites JW, Reebye V, Mintz P, et al., 2012, Cellular replacement and regenerative medicine therapies in ischemic stroke., Regen Med., Vol: 7
Kallis Y, Phillips N, Steel A, et al., 2012, Radiofrequency Ablation for Biliary Metal Stent Occlusion: Evolution of a Novel Endoscopic Technique and Proof of Concept, Digestive Disease Week (DDW), Publisher: MOSBY-ELSEVIER, Pages: 377-378, ISSN: 0016-5107
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- Citations: 6
Sethi A, Ellrichmann M, Dhar S, et al., 2012, EUS-Guided Lymph Node Ablation With Novel Radiofrequency Ablation Probe: A Feasibility Study, Digestive Disease Week (DDW), Publisher: MOSBY-ELSEVIER, Pages: 147-147, ISSN: 0016-5107
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- Citations: 4
Kahaleh M, Gaidhane M, Smith IB, et al., 2012, Endoscopic Ultrasound Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model: A Novel Palliative Option?, Digestive Disease Week (DDW), Publisher: MOSBY-ELSEVIER, Pages: 193-193, ISSN: 0016-5107
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- Citations: 3
Pai M, Frampton AE, Mikhail S, et al., 2012, Radiofrequency assisted liver resection: Analysis of 604 consecutive cases., Eur J Surg Oncol., Vol: 38, Pages: 274-280
Jiao LR, Frampton AE, Jacob J, et al., 2012, MicroRNAs Targeting Oncogenes Are Down-Regulated in Pancreatic Malignant Transformation from Benign Tumors, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 109
Reebye V, Frilling A, Hajitou A, et al., 2012, A perspective on non-catalytic Src homology (SH) adaptor signalling proteins, CELLULAR SIGNALLING, Vol: 24, Pages: 388-392, ISSN: 0898-6568
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- Citations: 13
Pai M, Kyriakides C, Xi F, et al., 2012, Laparoscopic hepatic transection using habib™ 4x, Open, Laparoscopic and Robotic Hepatic Transection: Tools and Methods, Pages: 119-122, ISBN: 9788847026216
Laparoscopic surgery has undergone a major transformation in the last two decades, with the advancement of new instruments, new techniques, and increased surgical experience and skill. Laparoscopic hepatic surgery is now not only feasible and safe, but depending on the indication, preferable, decreasing perioperative morbidity and hospital stay. Nevertheless, laparoscopic liver resection remains a highly challenging surgical procedure because of the risk of massive bleeding during liver transection and the complicated biliary and vascular anatomy of the liver. The Laparoscopic Habib™ 4X is a device specifically designed to address these issues. The device and technique of hepatic transection using the Laparoscopic Habib™ 4X are described.
Kyriakides C, Xi F, Pai M, et al., 2012, Open hepatic transection using habib<sup>tm</sup> 4x, Open, Laparoscopic and Robotic Hepatic Transection: Tools and Methods, Pages: 37-47, ISBN: 9788847026216
Liver resection is the principle treatment for primary and secondary malignancies as well as various benign diseases. The challenge of safely and efficiently transecting the hepatic parenchyma remains however. New technology, and specifically energy devices, have transformed the management of liver disease and the technique of liver resection, offering better hemostatic control and simplifying nonanatomical resection. The Habib 4X is a radiofrequency device used in resection of liver; the device and technique are presented.
Habib N, Katsimpoulos Z, 2012, Animal Models for hydrodynamic Gene Delivery, Chemical Biology, Editors: Ekinci, Publisher: Intech Web, ISBN: 978-953-51-0049-2
Gaidhane M, Smith I, Ellen K, et al., 2012, Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model, GASTROENTEROLOGY RESEARCH AND PRACTICE, Vol: 2012, ISSN: 1687-6121
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- Citations: 35
Banerjee S, Williamson DA, Habib N, et al., 2012, The potential benefit of stem cell therapy after stroke: an update., Vasc Health Risk Manag, Vol: 8, Pages: 569-580
Stroke is a leading cause of death and disability worldwide. Stem cell therapy is an emerging therapeutic modality with evidence of significant benefits in preclinical stroke models. A number of phase I and II clinical trials have now been completed, with several more currently under way. Translation to the bedside, however, remains a long way off, and there are many questions that remain unanswered. This review will summarize the current evidence and ongoing clinical trials worldwide, and explore the challenges to making this a realistic treatment option for the future.
Kayani B, Spalding DR, Jiao LR, et al., 2012, Does neostigmine improve time to resolution of symptoms in acute colonic pseudo-obstruction?, INTERNATIONAL JOURNAL OF SURGERY, Vol: 10, Pages: 453-457, ISSN: 1743-9191
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- Citations: 16
Vavra P, Ihnat P, Vavrova M, et al., 2012, Hand-assisted laparoscopic liver resection using Habib's technique: early experience, VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES, Vol: 7, Pages: 8-12, ISSN: 1895-4588
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- Citations: 6
Skouras C, Jarral O, Deshpande R, et al., 2012, Is early laparoscopic cholecystectomy for acute cholecystitis preferable to delayed surgery? Best evidence topic (BET), INTERNATIONAL JOURNAL OF SURGERY, Vol: 10, Pages: 250-258, ISSN: 1743-9191
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- Citations: 20
Pai M, Spalding D, Jiao L, et al., 2012, Use of Bipolar Radiofrequency in Parenchymal Transection of the Liver, Pancreas and Kidney, DIGESTIVE SURGERY, Vol: 29, Pages: 43-47, ISSN: 0253-4886
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- Citations: 21
Habib N, Asham E, 2012, Hepatocellular Carcinoma, Hepatic Surgery, Publisher: Intech, ISBN: 980-953-307-614-5
Pai M, Spalding D, Xi F, et al., 2012, Autologous Bone Marrow Stem Cells in the Treatment of Chronic Liver Disease, International Journal of Hepatology, Vol: 2012
Pai M, Kyriakides C, Mikhail S, et al., 2011, Radiofrequency-Assisted Hepatic Resection, ANNALS OF SURGICAL ONCOLOGY, Vol: 18, Pages: 3391-3391, ISSN: 1068-9265
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- Citations: 6
Kallis YN, Phillips N, Steel A, et al., 2011, FIRST REPORT OF THE LONG TERM EFFICACY OF A NOVEL ENDOSCOPIC RADIOFREQUENCY ABLATION TECHNIQUE FOR MALIGNANT BILIARY OBSTRUCTION, 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Publisher: WILEY-BLACKWELL, Pages: 1365A-1366A, ISSN: 0270-9139
Kallis Y, Phillips N, Steel A, et al., 2011, FIRST REPORT OF THE LONG-TERM EFFICACY OF A NOVEL ENDOSCOPIC RADIOFREQUENCY ABLATION TECHNIQUE FOR MALIGNANT BILIARY OBSTRUCTION, GUT, Vol: 60, Pages: A9-A9, ISSN: 0017-5749
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- Citations: 1
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