Publications
536 results found
HABIB NA, MICHAIL NE, BOYLE T, et al., 1994, RESECTION OF THE INFERIOR VENA-CAVA DURING HEPATECTOMY FOR LIVER-TUMORS, BRITISH JOURNAL OF SURGERY, Vol: 81, Pages: 1023-1024, ISSN: 0007-1323
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- Citations: 8
Ding SF, Delhanty JD, Zografos G, et al., 1994, Chromosome allele loss in colorectal liver metastases and its association with clinical features., Br J Surg, Vol: 81, Pages: 875-878, ISSN: 0007-1323
Molecular genetic changes are better characterized in colorectal carcinoma than in other common adult tumours. Consistent allele losses, or loss of heterozygosity (LOH), on chromosomes 5q, 17p and 18q have been well established. These changes are associated with the prognosis of the disease. Little is known of such changes in liver metastases of colorectal origin. The extent of allelic loss and its association with clinical features were investigated in 19 patients with colorectal liver metastases by using 24 probes to detect restriction fragment length polymorphism. A high frequency of LOH on chromosomes 5q, 17p and 18q was found in these secondary tumours. No consistent loss has so far been shown in any other chromosome. The frequency of allele loss correlated significantly with prognostic features such as the number and size of liver secondaries (P < 0.005), metastasis to the lymph nodes (P < 0.01) and curative or palliative operation (P < 0.02).
LI J, DING SF, HABIB NA, et al., 1994, PARTIAL CHARACTERIZATION OF A CDNA FOR HUMAN STEAROYL-COA DESATURASE AND CHANGES IN ITS MESSENGER-RNA EXPRESSION IN SOME NORMAL AND MALIGNANT-TISSUES, INTERNATIONAL JOURNAL OF CANCER, Vol: 57, Pages: 348-352, ISSN: 0020-7136
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- Citations: 107
DING SF, MICHAIL NE, HABIB NA, 1994, GENETIC CHANGES IN HEPATOBLASTOMA, JOURNAL OF HEPATOLOGY, Vol: 20, Pages: 672-675, ISSN: 0168-8278
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- Citations: 18
Jalleh RP, Smith PL, Habib NA, 1994, Two step mesoatrial shunt in Budd-Chiari syndrome. Case report., Eur J Surg, Vol: 160, Pages: 185-186, ISSN: 1102-4151
JALLEH RP, SMITH PLC, HABIB NA, 1994, 2-STEP MESOATRIAL SHUNT IN BUDD-CHIARI SYNDROME, EUROPEAN JOURNAL OF SURGERY, Vol: 160, Pages: 185-186, ISSN: 1102-4151
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- Citations: 2
HABIB NA, 1994, ELECTIVE HEPATIC RESECTION FOR BENIGN AND MALIGNANT LIVER-DISEASE - EARLY RESULTS - REPLY, BRITISH JOURNAL OF SURGERY, Vol: 81, Pages: 311-311, ISSN: 0007-1323
DING SF, CARRILLO A, DOOLEY JS, et al., 1993, MULTIPLE ALLELIC LOSSES IN SARCOMATOID LIVER-CARCINOMA, INTERNATIONAL HEPATOLOGY COMMUNICATIONS, Vol: 1, Pages: 295-301, ISSN: 0928-4346
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- Citations: 3
TARGARONA EM, ZOGRAFOS G, HABIB NA, 1993, LIVER RESECTION FOR RECURRENT HILAR CHOLANGIOCARCINOMA, BRITISH JOURNAL OF SURGERY, Vol: 80, Pages: 1433-1433, ISSN: 0007-1323
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- Citations: 12
HABIB N, ZOGRAFOS G, AWAD R, et al., 1993, CHANGING TRENDS IN HEPATIC RESECTION FOR MALIGNANT LIVER-TUMORS, INTERNATIONAL SURGERY, Vol: 78, Pages: 292-294, ISSN: 0020-8868
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- Citations: 2
HABIB NA, KOH MK, ZOGRAFOS G, et al., 1993, ELECTIVE HEPATIC RESECTION FOR BENIGN AND MALIGNANT LIVER-DISEASE - EARLY RESULTS, BRITISH JOURNAL OF SURGERY, Vol: 80, Pages: 1039-1041, ISSN: 0007-1323
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- Citations: 13
DING SF, DELHANTY JDA, CARRILLO A, et al., 1993, LACK OF DEMONSTRABLE CHROMOSOME ALLELE LOSS IN HEPATOCELLULAR ADENOMA, INTERNATIONAL JOURNAL OF ONCOLOGY, Vol: 2, Pages: 977-979, ISSN: 1019-6439
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- Citations: 5
DING SF, DELHANTY JDA, BOWLES L, et al., 1993, LOSS OF CONSTITUTIONAL HETEROZYGOSITY ON CHROMOSOME-5 AND CHROMOSOME-17 IN CHOLANGIOCARCINOMA, BRITISH JOURNAL OF CANCER, Vol: 67, Pages: 1007-1010, ISSN: 0007-0920
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- Citations: 26
Ding SF, Delhanty JD, Bowles L, et al., 1993, Loss of constitutional heterozygosity on chromosomes 5 and 17 in cholangiocarcinoma., Br J Cancer, Vol: 67, Pages: 1007-1010, ISSN: 0007-0920
It has been established that loss of tumour suppressor genes is crucial in carcinogenesis. There has been no reported study on searching for tumour suppressor genes in cholangiocarcinomas as yet. In order to investigate the loss of heterozygosity (LOH), which may represent such gene loss, in cholangiocarcinoma, we studied 14 patients with this tumour using restriction fragment length polymorphism analysis. Twenty-two probes assigned to chromosomes 1, 5, 7, 9, 11, 12, 13, 14, 16, 17 and 18 were used. Allelic losses were found in chromosomal regions 5q35-qter and 17p13. Loss of genetic material in these regions in cholangiocarcinoma was shared with hepatocellular carcinoma. Probes for other chromosomes have as yet shown no consistent LOH. In conclusion, this study for the first time showed LOH on chromosomes 5 and 17 in cholangiocarcinoma.
HABIB NA, HIGGS BD, MARWAN I, et al., 1993, LIVING-RELATED LIVER-TRANSPLANTATION IN AFRICA, INTERNATIONAL SURGERY, Vol: 78, Pages: 121-123, ISSN: 0020-8868
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- Citations: 8
Ding SF, Jalleh RP, Dooley J, et al., 1993, Chromosome 17 allele loss in hepatocellular carcinoma but not in synchronous liver adenoma., Eur J Surg Oncol, Vol: 19, Pages: 195-197, ISSN: 0748-7983
A 51-year-old female underwent resection of two synchronous liver tumours, a hepatocellular carcinoma and an adenoma. DNA analysis revealed allele loss on chromosome 17 (17p13, near the locus of p53 tumour suppressor gene) in the hepatocellular carcinoma but not in the adenoma. This finding may support the view that loss of p53 tumour suppressor gene is associated with tumour progression.
DING SF, DELHANTY JDA, BOWLES L, et al., 1993, INFREQUENT CHROMOSOME ALLELE LOSS IN FIBROLAMELLAR CARCINOMA, BRITISH JOURNAL OF CANCER, Vol: 67, Pages: 244-246, ISSN: 0007-0920
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- Citations: 16
CARDOSO JE, CALMUS Y, LEGENDRE C, et al., 1993, AUGMENTED PORTAL FLOW IN THE ISOLATED PERFUSED CIRRHOTIC RAT-LIVER - A HEMODYNAMIC AND MORPHOLOGICAL-STUDY, CLINICAL SCIENCE, Vol: 84, Pages: 185-192, ISSN: 0143-5221
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- Citations: 12
Habib N, Davidson B, 1993, The Liver, Operative Surgery and Management (3rd Edition), Editors: Keen, Farndon, Publisher: Butterworths-Heinemann, Pages: 193-209
DING SF, DELHANTY JDA, DOOLEY JS, et al., 1993, THE PUTATIVE TUMOR-SUPPRESSOR GENE ON CHROMOSOME-5Q FOR HEPATOCELLULAR-CARCINOMA IS DISTINCT FROM THE MCC AND APC GENES, CANCER DETECTION AND PREVENTION, Vol: 17, Pages: 405-409, ISSN: 0361-090X
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- Citations: 18
Kelly SB, Habib NA, Blumgart LH, 1993, Long-term survival in a patient following resection for carcinoma of the gallbladder and rectum., HPB Surg, Vol: 7, Pages: 165-174, ISSN: 0894-8569
We describe a 66-year-old man who presented initially with acute cholecystitis. He was treated by cholecystostomy and biopsy of the gallbladder mucosa which revealed carcinoma of the gallbladder. Four weeks later a cholecystectomy was performed followed by resection of the common bile duct, common hepatic duct and segments IV and V of the liver and a hepaticojejunostomy. Sixteen months later an abdomino-perineal resection was performed for a moderately differentiated Dukes' stage C carcinoma of the rectum. He is alive and without evidence of recurrence seven years later. Few patients survive for this length of time following resection of either carcinoma of the gallbladder or rectum. This case report demonstrates the value of aggressive surgical treatment in patients with early carcinoma of the gallbladder.
DING SF, JALLEH RP, WOOD CB, et al., 1992, DIFFERENT DNA CHANGES IN PRIMARY AND RECURRENT HEPATOCELLULAR-CARCINOMA, GUT, Vol: 33, Pages: 1433-1435, ISSN: 0017-5749
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- Citations: 10
Watanapa P, Ahmad H, Williamson RC, et al., 1992, Repeat hepatic resection for metachronous carcinoma of the liver., J R Coll Surg Edinb, Vol: 37, Pages: 252-254, ISSN: 0035-8835
KELLY SB, COOPER J, LLEWELLYN S, et al., 1992, IODOSTEARIC ACID IN THE TREATMENT OF ADVANCED GASTROINTESTINAL CARCINOMA, EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, Vol: 18, Pages: 357-361, ISSN: 0748-7983
DING SF, WONG K, DAVIDSON B, et al., 1992, DIFFERENCES IN THE TUMOR DNA ANALYSIS OF A HEPATOCELLULAR-CARCINOMA AND A SYNCHRONOUS FIBROLAMELLAR VARIANT, INTERNATIONAL JOURNAL OF ONCOLOGY, Vol: 1, Pages: 191-193, ISSN: 1019-6439
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- Citations: 2
SWIFT RI, GAER J, WORMAN C, et al., 1992, INVITRO SENSITIZED AUTOLOGOUS TUMORICIDAL LYMPHOCYTES TO COLONIC ADENOCARCINOMA, EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, Vol: 18, Pages: 258-263, ISSN: 0748-7983
DING SF, HABIB NA, DELHANTY JDA, et al., 1992, LOSS OF HETEROZYGOSITY ON CHROMOSOME-1 AND CHROMOSOME-11 IN CARCINOMA OF THE PANCREAS, BRITISH JOURNAL OF CANCER, Vol: 65, Pages: 809-812, ISSN: 0007-0920
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- Citations: 33
DING SF, HABIB NA, DELHANTY J, et al., 1992, ALLELE LOSS ON CHROMOSOME-1 AND CHROMOSOME-II IN CARCINOMA OF THE PANCREAS, GUT, Vol: 33, Pages: A428-A428, ISSN: 0017-5749
CHESLYNCURTIS S, EMBERTON M, AHMED H, et al., 1992, BILE-DUCT INJURY FOLLOWING LAPAROSCOPIC CHOLECYSTECTOMY, BRITISH JOURNAL OF SURGERY, Vol: 79, Pages: 231-232, ISSN: 0007-1323
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- Citations: 22
DAVIDSON B, CARRATTA R, PACCIONE F, et al., 1991, SURGICAL EMERGENCIES IN LIVER-DISEASE, BAILLIERES CLINICAL GASTROENTEROLOGY, Vol: 5, Pages: 737-758, ISSN: 0950-3528
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- Citations: 3
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