Publications
535 results found
Reebye V, Levicar N, Habib N, 2011, Stem Cell Therapy for Patients with Chronic Liver Disease, Stem Cells in Clinic and Research, Pages: 501-512, ISBN: 978-953-307-797-0
Adult stem cells are a population of immature cells that have the capability of self renewalto provide the human body with a constant source of cells for maintaining healthy tissues orreplacing those that are damaged. Our present day scientific developments alongsideclinical experiences have collectively consolidated our understanding of the signals thatmediate stem cell lineage commitment and differentiation. From this, the concept of usingadult stem cells to repopulate chronically diseased organs is now a feasible option forregenerative medicine.Whilst the use of human embryonic stem cells in the clinical setting has beenoverwhelmingly marred by its oncogenic potential as well as ethical concerns, the rate ofprogress in understanding the complex developmental plasticity of adult stem cells, inparticular those derived from the bone marrow, has successfully allowed their use fortranslational research with unattached ethical issues. The pioneering use of bone marrowstem cells in the 1960s as a viable treatment option for leukaemia, myeloma and lymphomahas come a long way since then. Today we are able to use these stem cells to give rise tobone and cartilage (1) and to repair both cardiac and liver function (2, 3). Since a detailedreview for each of these exciting developments is too broad for this chapter, we will mainlyfocus on the use of bone marrow derived stem cell for the treatment of chronic liver disease.
Tsim N, Healey AJ, Frampton AE, et al., 2011, Two-Stage Resection for Bilobar Colorectal Liver Metastases: R0 Resection Is the Key, ANNALS OF SURGICAL ONCOLOGY, Vol: 18, Pages: 1939-1946, ISSN: 1068-9265
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- Citations: 39
Reebye V, Frilling A, Habib NA, et al., 2011, Intracellular adaptor molecules and AR signalling in the tumour microenvironment, CELLULAR SIGNALLING, Vol: 23, Pages: 1017-1021, ISSN: 0898-6568
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- Citations: 14
McGuigan C, Habib NA, Wasan HS, et al., 2011, A phosphoramidate ProTide (NUC-1031) and acquired and intrinsic resistance to gemcitabine., J Clin Oncol, Vol: 29
e13540 Background: Resistance to gemcitabine is a major problem in the treatment of cancer. The key resistance mechanisms associated with gemcitabine are: lack of nucleoside transporters; lack of kinases for phosphorylation; and/or, rapid metabolism by deaminases. Resistance results in complete response rates of less than 10% in pancreatic cancer. The addition of a phosphoramidate ProTide moiety to gemcitabine enables: passive entry into the cell, by-passing the reliance on transporters; reduced reliance on kinases for phosphorylation; and, less susceptibility to deamination. METHODS: The ProTide (NUC-1031) was compared to the parent molecule (gemcitabine) in two pancreatic tumor xenograft models: Mia-Pa-Ca-2 (n=40), which is partially responsive to gemcitabine; and BxPC-3 (n=40), which is resistant. Two dose regimens for each tumor type were used, with NUC-1031 administered IP at doses of 0.076 or 0.19 mMol/kg when tumors had reached 150 - 200mm(3). The objective was to determine the ability of a novel agent (NUC-1031) to overcome gemcitabine resistance by measuring tumor growth in partially responsive and resistant pancreatic cell lines. RESULTS: The anti-tumor effect of NUC-1031 was greater and longer lasting than that of gemcitabine and control in both cell lines. NUC-1031 inhibition of tumor growth was significantly different from control in Mia-Pa-Ca-2 on days 4, 11, 14, 18, 21 and 25, and in BxPC-3 cells on days 25, 29, 33 and 37. In Mia-Pa-Ca-2 the tumor volume decreased immediately after first dosing and held at low levels until the end of the experiment. NUC-1031 was well tolerated and animals lost <2% body weight on treatment and this was regained rapidly after cessation of treatment. CONCLUSIONS: NUC-1031 showed statistically significant reduction in pancreatic tumor volume compared with gemcitabine and control. A phase I/II study of NUC-1031 in resistant/refractory pancreatic cancer is scheduled.
McGuigan C, Habib NA, Wasan HS, et al., 2011, A phosphoramidate ProTide (NUC-1031) and acquired and intrinsic resistance to gemcitabine, JOURNAL OF CLINICAL ONCOLOGY, Vol: 29, ISSN: 0732-183X
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- Citations: 7
Karunanithy N, Gordon F, Hodolic M, et al., 2011, Embolization of Hepatic Arterial Branches to Simplify Hepatic Blood Flow Before Yttrium 90 Radioembolization: A Useful Technique in the Presence of Challenging Anatomy, CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, Vol: 34, Pages: 287-294, ISSN: 0174-1551
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- Citations: 13
Banerjee S, Williamson D, Habib N, et al., 2011, Human stem cell therapy in ischaemic stroke: a review, AGE AND AGEING, Vol: 40, Pages: 7-13, ISSN: 0002-0729
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- Citations: 40
Steel AW, Postgate AJ, Khorsandi S, et al., 2011, Endoscopically applied radiofrequency ablation appears to be safe in the treatment of malignant biliary obstruction, GASTROINTESTINAL ENDOSCOPY, Vol: 73, Pages: 149-153, ISSN: 0016-5107
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- Citations: 212
Karunanithy N, Gordon F, Hodolic M, et al., 2011, Embolisation of hepatic arterial branches to simplify hepatic blood flow before Yttrium 90 radioembolisation, Cardiovascular Interventional Radiology, Vol: 34, Pages: 287-294
Steel AW, Postgate AJ, Khorsandi SE, et al., 2011, Endoscopically applied radiofrequency ablation appears safe in the treatment of malignant biliary obstruction, Gastrointestinal Endoscopy, Vol: 73, Pages: 149-153
du Potet E, Cameron L, Habib NA, et al., 2011, Cancer Stem Cells in Solid Tumors, STEM CELLS AND REGENERATIVE MEDICINE: FROM MOLECULAR EMBRYOLOGY TO TISSUE ENGINEERING, Editors: Appasani, Appasani, Publisher: HUMANA PRESS INC, Pages: 59-76, ISBN: 978-1-60761-859-1
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- Citations: 2
Zacharoulis D, Lazoura O, Rountas C, et al., 2011, Experimental animal study of a novel radiofrequency endovascular occlusion device, The American Journal of Surgery, Vol: 201, Pages: 103-109
Lazoura O, Zacharoulis D, Kanavou T, et al., 2011, A novel experimental model of arterial stenosis based on endovascular radiofrequency energy application, Journal of Investigative Surgery, Vol: 24, Pages: 123-128
Katsimpoulos M, Zacharoulis D, Rountas C, et al., 2011, Minimal invasive technique for gene delivery in porcine liver lobe segment, Journal of Investigative Surgery, Vol: 24, Pages: 13-17
Williamson JML, Thairu N, Katsoulas N, et al., 2010, Impact of portal vein embolization on expression of cancer stem cell markers in regenerated liver and colorectal liver metastases, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, Vol: 45, Pages: 1472-1479, ISSN: 0036-5521
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- Citations: 7
Reebye V, Bevan CL, Nohadani M, et al., 2010, Interaction between AR signalling and CRKL bypasses casodex inhibition in prostate cancer, CELLULAR SIGNALLING, Vol: 22, Pages: 1874-1881, ISSN: 0898-6568
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- Citations: 4
Pitchaimuthu M, Pai M, Habib NA, 2010, Partial nephrectomy and enbloc liver resection using a bipolar radiofrequency device for renal cell carcinoma invading the liver., BMJ Case Rep, Vol: 2010
A 66-year-old man presented with right- sided abdominal pain. Ultrasound, CT and MRI scans showed a right renal mass arising from the upper pole with direct involvement of the right lobe of the liver. Biopsy confirmed renal cell carcinoma. After Multi Disciplinary Team (MDT) discussion, right partial nephrectomy with enbloc resection of segments VI and VII of the liver was performed with the help of intraoperative ultrasound scan and the Habib 4X bipolar radiofrequency device. Apart from symptomatic collection, which was drained radiologically, the patient made a good recovery. The patient developed recurrence at the resection margin but is in remission following chemotherapy at 12 months.
Farzaneh F, Chan L, Hardwick N, et al., 2010, Immune Gene Therapy for Acute Myeloid Leukaemia, 7th Annual Meeting of German-Society-for-Gene-Therapy (DG-GT e.V.), Publisher: MARY ANN LIEBERT INC, Pages: 1177-1178, ISSN: 1043-0342
Oishi H, Sunamura M, Egawa S, et al., 2010, Blockade of Delta-Like Ligand 4 Signaling Inhibits Both Growth and Angiogenesis of Pancreatic Cancer, PANCREAS, Vol: 39, Pages: 897-903, ISSN: 0885-3177
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- Citations: 29
Jiao LR, Szydlo R, Habib NA, et al., 2010, Circulating Tumor Cells and Sample Size: The More, the Better Reply, JOURNAL OF CLINICAL ONCOLOGY, Vol: 28, Pages: E290-E290, ISSN: 0732-183X
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- Citations: 1
Curro G, Navarra G, Barbera A, et al., 2010, Concerns About Ultrasound-Guided Radiofrequency-Assisted Segmental Liver Resection <i>Reply</i>, ANNALS OF SURGERY, Vol: 251, Pages: 1192-1193, ISSN: 0003-4932
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- Citations: 2
Curro G, Navarra G, Barbera A, et al., 2010, Concerns about ultrasound-guided radiofrequency-assisted segmental liver resection., Annals of Surgery, Vol: 251 (6), Pages: 1192-1193
Frampton AE, Castellano L, Tsim N, et al., 2010, MicroRNA expression profiles in pancreatic cystic tumors, JOURNAL OF CLINICAL ONCOLOGY, Vol: 28, ISSN: 0732-183X
McKay S, Pericleous S, Kent-Bramer J, et al., 2010, Surgical Management of Cholangiocarcinoma, 9th World Congress of the International Hepato-Pancreato-Biliary Association, Pages: 1-468
Pericleous S, McKay S, Mezes P, et al., 2010, Surgery for metastases to the pancreas., 9th World Congress of the International Hepato-Pancreato-Biliary Association, Pages: 1-468
Charif R, Marley S, Gordon M, et al., 2010, Phase I Clinical Study of Autologous Infusion of Expanded Mobilized Adult Bone Marrow-Derived CD34 Cells into Diabetic Patients with Renal Transplants., 10th American Transplant Congress, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 233-234, ISSN: 1600-6135
Steel A, Postgate A, Vlavianos P, et al., 2010, THE USE OF A NOVEL ENDOSCOPICALLY PLACED RADIOFREQUENCY PROBE FOR THE MANAGEMENT OF MALIGNANT BILE DUCT OBSTRUCTION, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A56-A57, ISSN: 0017-5749
Granio O, Excoffon KJ, Henning P, et al., 2010, Adenovirus 5-Fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia, Human Gene Therapy, Pages: 251-269
Tsim NC, Frampton AE, Habib NA, et al., 2010, Surgical treatment for liver cancer, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 16, Pages: 927-933, ISSN: 1007-9327
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- Citations: 48
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