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@article{Glasbey:2021:10.1016/s1470-2045(21)00493-9,
author = {Glasbey, J and Ademuyiwa, A and Adisa, A and AlAmeer, E and Arnaud, AP and Ayasra, F and Azevedo, J and Minaya-Bravo, A and Costas-Chavarri, A and Edwards, J and Elhadi, M and Fiore, M and Fotopoulou, C and Gallo, G and Ghosh, D and Griffiths, EA and Harrison, E and Hutchinson, P and Lawani, I and Lawday, S and Lederhuber, H and Leventoglu, S and Li, E and Gomes, GMA and Mann, H and Marson, EJ and Martin, J and Mazingi, D and McLean, K and Modolo, M and Moore, R and Morton, D and Ntirenganya, F and Pata, F and Picciochi, M and Pockney, P and Ramos-De, la Medina A and Roberts, K and Roslani, AC and Kottayasamy, Seenivasagam R and Shaw, R and Simões, JFF and Smart, N and Stewart, GD and Sullivan, R and Sundar, S and Tabiri, S and Taylor, EH and Vidya, R and Nepogodiev, D and Bhangu, A and Glasbey, JC and McLean, K and Nepogodiev, D and Harrison, E and Bhangu, AA and Nepogodiev, D and Siaw-Acheampong, K and Benson, RA and Bywater, E and Chaudhry, D and Dawson, BE and Evans, JP and Glasbey},
doi = {10.1016/s1470-2045(21)00493-9},
journal = {The Lancet Oncology},
pages = {1507--1517},
title = {Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study},
url = {http://dx.doi.org/10.1016/s1470-2045(21)00493-9},
volume = {22},
year = {2021}
}

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TY  - JOUR
AB  - BackgroundSurgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction.MethodsThis international, prospective, cohort study enrolled 20006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index <20), moderate lockdowns (20–60), and full lockdowns (>60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926.FindingsOf eligible patients awaiting surgery, 2003 (10·0%) of 20006 did not receive surgery after a median follow-up of 23 weeks (IQR 16–30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646; adjusted hazard ratio [HR] 0·81, 95% CI 0·77–0·84; p<0·0001), and full lockdowns with a 15·0% rate (1775 of 11827; HR 0·51, 0·50–0·53; p<0·0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notif
AU  - Glasbey,J
AU  - Ademuyiwa,A
AU  - Adisa,A
AU  - AlAmeer,E
AU  - Arnaud,AP
AU  - Ayasra,F
AU  - Azevedo,J
AU  - Minaya-Bravo,A
AU  - Costas-Chavarri,A
AU  - Edwards,J
AU  - Elhadi,M
AU  - Fiore,M
AU  - Fotopoulou,C
AU  - Gallo,G
AU  - Ghosh,D
AU  - Griffiths,EA
AU  - Harrison,E
AU  - Hutchinson,P
AU  - Lawani,I
AU  - Lawday,S
AU  - Lederhuber,H
AU  - Leventoglu,S
AU  - Li,E
AU  - Gomes,GMA
AU  - Mann,H
AU  - Marson,EJ
AU  - Martin,J
AU  - Mazingi,D
AU  - McLean,K
AU  - Modolo,M
AU  - Moore,R
AU  - Morton,D
AU  - Ntirenganya,F
AU  - Pata,F
AU  - Picciochi,M
AU  - Pockney,P
AU  - Ramos-De,la Medina A
AU  - Roberts,K
AU  - Roslani,AC
AU  - Kottayasamy,Seenivasagam R
AU  - Shaw,R
AU  - Simões,JFF
AU  - Smart,N
AU  - Stewart,GD
AU  - Sullivan,R
AU  - Sundar,S
AU  - Tabiri,S
AU  - Taylor,EH
AU  - Vidya,R
AU  - Nepogodiev,D
AU  - Bhangu,A
AU  - Glasbey,JC
AU  - McLean,K
AU  - Nepogodiev,D
AU  - Harrison,E
AU  - Bhangu,AA
AU  - Nepogodiev,D
AU  - Siaw-Acheampong,K
AU  - Benson,RA
AU  - Bywater,E
AU  - Chaudhry,D
AU  - Dawson,BE
AU  - Evans,JP
AU  - Glasbey,JC
AU  - Gujjuri,RR
AU  - Heritage,E
AU  - Jones,CS
AU  - Kamarajah,SK
AU  - Khatri,C
AU  - Khaw,RA
AU  - Keatley,JM
AU  - Knight,A
AU  - Lawday,S
AU  - Li,E
AU  - Mann,HS
AU  - Marson,EJ
AU  - McLean,KA
AU  - Mckay,SC
AU  - Mills,EC
AU  - Pellino,G
AU  - Picciochi,M
AU  - Taylor,EH
AU  - Tiwari,A
AU  - Simoes,JFF
AU  - Trout,IM
AU  - Venn,ML
AU  - Wilkin,RJW
AU  - Bhangu,A
AU  - Glasbey,JC
AU  - Smart,NJ
AU  - Minaya-Bravo,A
AU  - Evans,JP
AU  - Gallo,G
AU  - Moug,S
AU  - Pata,F
AU  - Pockney,P
AU  - Di,Saverio S
AU  - Vallance,A
AU  - Vimalchandran,D
AU  - Griffiths,EA
AU  - Kamarajah,SK
AU  - Evans,RPT
AU  - Townend,P
AU  - Roberts,K
AU  - McKay,S
AU  - Isaac,J
AU  - Satoi,S
AU  - Edwards,J
AU  - Coonar,AS
AU  - Marchbank,A
AU  - Caruana,EJ
AU  - Layton,GR
AU  - Patel,A
AU  - Brunelli,A
AU  - Ford,S
AU  - Desai,A
AU  - Gronchi,A
AU  - Fiore,M
AU  - Almond,M
AU  - Tirotta,F
AU  - Dumitra,S
AU  - Kolias,A
AU  - Price,SJ
AU  - Fountain,DM
AU  - Jenkinson,MD
AU  - Hutchinson,P
AU  - Marcus,HJ
AU  - Piper,RJ
AU  - Lippa,L
AU  - Servadei,F
AU  - Esene,I
AU  - Freyschlag,C
AU  - Neville,I
AU  - Rosseau,G
AU  - Schaller,K
AU  - Demetriades,AK
AU  - Robertson,F
AU  - Alamri,A
AU  - Shaw,R
AU  - Schache,AG
AU  - Winter,SC
AU  - Ho,M
AU  - Nankivell,P
AU  - Rey,Biel J
AU  - Batstone,M
AU  - Ganly,I
AU  - Vidya,R
AU  - Wilkins,A
AU  - Singh,JK
AU  - Thekinkattil,D
AU  - Sundar,S
AU  - Fotopoulou,C
AU  - Leung,EYL
AU  - Khan,T
AU  - Chiva,L
AU  - Sehouli,J
AU  - Fagotti,A
AU  - Cohen,P
AU  - Gutelkin,M
AU  - Ghebre,R
AU  - Konney,T
AU  - Pareja,R
AU  - Bristow,R
AU  - Dowdy,S
AU  - Shylasree,TS
AU  - Kottayasamy,Seenivasagam R
AU  - Ng,J
AU  - Fujiwara,K
AU  - Stewart,GD
AU  - Lamb,B
AU  - Narahari,K
AU  - McNeill,A
AU  - Colquhoun,A
AU  - McGrath,JS
AU  - Bromage,S
AU  - Barod,R
AU  - Kasivisva
DO  - 10.1016/s1470-2045(21)00493-9
EP  - 1517
PY  - 2021///
SN  - 1470-2045
SP  - 1507
TI  - Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
T2  - The Lancet Oncology
UR  - http://dx.doi.org/10.1016/s1470-2045(21)00493-9
UR  - https://www.sciencedirect.com/science/article/pii/S1470204521004939?via%3Dihub
UR  - http://hdl.handle.net/10044/1/91973
VL  - 22
ER  -

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