The Origins of Bone and Cartilage Disease Project (OBCD)
The Origins of Bone and Cartilage Disease (OCBD) project will test over 1600 mutant strains with single gene deletions for abnormalities of bone structure and strength, and abnormalities of joint shape, structure and surface integrity. This work will identify new genes that specify bone and joint structure and function, and will provide new disease models for skeletal disorders.
Osteoarthritis (OA) is the most common joint disorder and its incidence is increasing with an aging population. Whilst approximately 50% of an individual's risk of developing OA is inherited, thus far, few genetic loci have been associated with the disease. Hence there is an urgent need to identify genes involved in the susceptibility to and progression of OA.
The mouse is an essential model for the study of bone and joint disease due to its genetic tractability and wealth of available resources. One such resource is the Sanger Mouse Pipeline (SMP) at the Wellcome Trust Sanger Institute. The SMP is part of the International Mouse Phenotyping Consortium (IMPC), which is deleting each of the >20,000 protein-coding genes in C57/BL6 mice by 2021. The Origins of Bone and Cartilage Disease (OBCD) initiative is an international consortium that is phenotyping mouse mutants generated by the SMP and IMPC to identify genetic determinants of bone and joint disease.