Research in the Kamaly group is highly multidisciplinary and uses bioinspired approaches to synthesise targeted multi-functional polymeric nanomedicines capable of changing their surface or core properties in response to local or up-regulated disease markers for stimuli-responsive and spatiotemporally controlled biological drug delivery. These polymeric nanomedicines are synthesised using nanopolymerisation reactions in confined droplets. We also investigate nanomedicine bio-efficacy using biomimetic models with controlled environmental parameters for testing nanoparticle physicochemical properties. This facilitates a more dynamic biological mechanistic insight between nanoparticles and target cell populations.
Biography. Prior to joining the Chemistry Department in 2019, Nazila was an Associate Professor at the Technical University of Denmark, Department of Micro and Nanotechnology and the Department of Health Technology, where she was awarded a prestigious Lundbeck Fellowship to develop targeted nanomedicines for heart disease (2016-present). Prior to this she was an Instructor in the Laboratory of Nanomedicine and Biomaterials at Harvard Medical School (2013-2015) where she pioneered targeted polymeric anti-inflammatory nanomedicines for heart disease. She also carried out a number of postdoctoral research positions within the same laboratory headed by Professor Omid Farokhzad (2011-2013), affiliated with the laboratory of Prof. Robert Langer at MIT (2011-2015), and also previously at Imperial College London Chemistry Department within the laboratory of Prof. Nick Long and other groups in the Faculty of Medicine (2007-2010), where she developed nanomedicines, nanodiagnostics and nanotheranostics for inflammation, heart disease and dual cancer imaging and therapy. She obtained an MSci degree in Medicinal Chemistry from University College London (2002), and a PhD in Bioorganic Chemistry from Imperial College London, Department of Chemistry (2008).
Morgulchik N, Kamaly N, 2021, Meta-analysis of In Vitro Drug-Release Parameters Reveals Predictable and Robust Kinetics for Redox-Responsive Drug-Conjugated Therapeutic Nanogels, Acs Applied Nano Materials, Vol:4, ISSN:2574-0970, Pages:4256-4268
et al., 2021, Effect of Nanoparticle Biophysicochemical Properties on Binding and Transport across Cardiovascular Endothelial Dysfunction Models, Acs Applied Nano Materials, Vol:4, ISSN:2574-0970, Pages:4077-4091
et al., 2021, Simultaneous Cross-Linking and Cross-Polymerization of Enzyme Responsive Polyethylene Glycol Nanogels in Confined Aqueous Droplets for Reduction of Low-Density Lipoprotein Oxidation, Biomacromolecules, Vol:22, ISSN:1525-7797, Pages:386-398
et al., 2021, Ac2-26-Nanoparticles Induce Resolution of Intestinal Inflammation and Anastomotic Healing via Inhibition of NF-κB Signaling in a Model of Perioperative Colitis., Inflamm Bowel Dis
et al., 2020, An innovative and eco-friendly modality for synthesis of highly fluorinated graphene by an acidic ionic liquid: Making of an efficacious vehicle for anti-cancer drug delivery, Applied Surface Science, Vol:515, ISSN:0169-4332