Imperial College London
Alternate

Professor Neil Ferguson

Faculty of Medicine, School of Public Health

Director of the School of Public Health
 
 
 
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Contact

 

+44 (0)20 7594 3296neil.ferguson Website

 
 
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Location

 

508School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Laydon:2022:10.1101/2022.04.06.22273497,
author = {Laydon, DJ and Cauchemez, S and Hinsley, WR and Bhatt, S and Ferguson, NM},
doi = {10.1101/2022.04.06.22273497},
title = {Prophylactic and reactive vaccination strategies for healthcare workers against MERS-CoV},
url = {http://dx.doi.org/10.1101/2022.04.06.22273497},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Several vaccines candidates are in development against Middle East respiratory syndrome–related coronavirus (MERS-CoV), which remains a major public health concern. Using individual-level data on the 2013-2014 Kingdom of Saudi Arabia epidemic, we employ counterfactual analysis on inferred transmission trees (“who-infected-whom”) to assess potential vaccine impact. We investigate the conditions under which prophylactic “proactive” campaigns would outperform “reactive” campaigns (i.e. vaccinating either before or in response to the next outbreak), focussing on healthcare workers. Spatial scale is crucial: if vaccinating healthcare workers in response to outbreaks at their hospital only, proactive campaigns perform better, unless efficacy has waned significantly. However, campaigns that react at regional or national level consistently outperform proactive campaigns. Measures targeting the animal reservoir reduce transmission linearly, albeit with wide uncertainty. Substantial reduction of MERS-CoV morbidity and mortality is possible when vaccinating healthcare workers, underlining the need for at-risk countries to stockpile vaccines when available.</jats:p>
AU  - Laydon,DJ
AU  - Cauchemez,S
AU  - Hinsley,WR
AU  - Bhatt,S
AU  - Ferguson,NM
DO  - 10.1101/2022.04.06.22273497
PY  - 2022///
TI  - Prophylactic and reactive vaccination strategies for healthcare workers against MERS-CoV
UR  - http://dx.doi.org/10.1101/2022.04.06.22273497
ER  -
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