Imperial College London
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DrNeilGraham

Faculty of Medicine, Department of Brain Sciences

Clinical Lecturer
 
 
 
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Contact

 

neil.graham

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Graham:2020:10.1136/bmjopen-2020-042093,
author = {Graham, NSN and Zimmerman, KA and Bertolini, G and Magnoni, S and Oddo, M and Zetterberg, H and Moro, F and Novelli, D and Heslegrave, A and Chieregato, A and Fainardi, E and Fleming, JM and Garbero, E and Abed-Maillard, S and Gradisek, P and Bernini, A and Sharp, DJ},
doi = {10.1136/bmjopen-2020-042093},
journal = {BMJ Open},
pages = {1--9},
title = {Multicentre longitudinal study of fluid and neuroimaging BIOmarkers of AXonal injury after traumatic brain injury: the BIO-AX-TBI study protocol.},
url = {http://dx.doi.org/10.1136/bmjopen-2020-042093},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION AND AIMS: Traumatic brain injury (TBI) often results in persistent disability, due particularly to cognitive impairments. Outcomes remain difficult to predict but appear to relate to axonal injury. Several new approaches involving fluid and neuroimaging biomarkers show promise to sensitively quantify axonal injury. By assessing these longitudinally in a large cohort, we aim both to improve our understanding of the pathophysiology of TBI, and provide better tools to predict clinical outcome. METHODS AND ANALYSIS: BIOmarkers of AXonal injury after TBI is a prospective longitudinal study of fluid and neuroimaging biomarkers of axonal injury after moderate-to-severe TBI, currently being conducted across multiple European centres. We will provide a detailed characterisation of axonal injury after TBI, using fluid (such as plasma/microdialysate neurofilament light) and neuroimaging biomarkers (including diffusion tensor MRI), which will then be related to detailed clinical, cognitive and functional outcome measures. We aim to recruit at least 250 patients, including 40 with cerebral microdialysis performed, with serial assessments performed twice in the first 10 days after injury, subacutely at 10 days to 6 weeks, at 6 and 12 months after injury. ETHICS AND DISSEMINATION: The relevant ethical approvals have been granted by the following ethics committees: in London, by the Camberwell St Giles Research Ethics Committee; in Policlinico (Milan), by the Comitato Etico Milano Area 2; in Niguarda (Milan), by the Comitato Etico Milano Area 3; in Careggi (Florence), by the Comitato Etico Regionale per la Sperimentazione Clinica della Regione Toscana, Sezione area vasta centro; in Trento, by the Trento Comitato Etico per le Sperimentazioni Cliniche, Azienda Provinciale per i Servizi Sanitari della Provincia autonoma di Trento; in Lausanne, by the Commission cantonale d'éthique de la recherche sur l'être humain; in Ljubljana, by the National Medical
AU  - Graham,NSN
AU  - Zimmerman,KA
AU  - Bertolini,G
AU  - Magnoni,S
AU  - Oddo,M
AU  - Zetterberg,H
AU  - Moro,F
AU  - Novelli,D
AU  - Heslegrave,A
AU  - Chieregato,A
AU  - Fainardi,E
AU  - Fleming,JM
AU  - Garbero,E
AU  - Abed-Maillard,S
AU  - Gradisek,P
AU  - Bernini,A
AU  - Sharp,DJ
DO  - 10.1136/bmjopen-2020-042093
EP  - 9
PY  - 2020///
SN  - 2044-6055
SP  - 1
TI  - Multicentre longitudinal study of fluid and neuroimaging BIOmarkers of AXonal injury after traumatic brain injury: the BIO-AX-TBI study protocol.
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2020-042093
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33172948
UR  - https://bmjopen.bmj.com/content/10/11/e042093
UR  - http://hdl.handle.net/10044/1/84211
VL  - 10
ER  -
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