Imperial College London
Dr Neil Murphy

DrNeilMurphy

Faculty of Medicine, School of Public Health

Honorary Senior Research Fellow
 
 
 
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Contact

 

neil.murphy

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Matta:2021:10.1186/s12916-021-01952-3,
author = {Matta, M and Huybrechts, I and Biessy, C and Casagrande, C and Yammine, S and Fournier, A and Olsen, KS and Lukic, M and Gram, IT and Ardanaz, E and Sánchez, M-J and Dossus, L and Fortner, RT and Srour, B and Jannasch, F and Schulze, MB and Amiano, P and Agudo, A and Colorado-Yohar, S and Quirós, JR and Tumino, R and Panico, S and Masala, G and Pala, V and Sacerdote, C and Tjønneland, A and Olsen, A and Dahm, CC and Rosendahl, AH and Borgquist, S and Wennberg, M and Heath, AK and Aune, D and Schmidt, J and Weiderpass, E and Chajes, V and Gunter, MJ and Murphy, N},
doi = {10.1186/s12916-021-01952-3},
journal = {BMC Medicine},
pages = {1--11},
title = {Dietary intake of trans fatty acids and breast cancer risk in 9 European countries},
url = {http://dx.doi.org/10.1186/s12916-021-01952-3},
volume = {19},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundTrans fatty acids (TFAs) have been hypothesised to influence breast cancer risk. However, relatively few prospective studies have examined this relationship, and well-powered analyses according to hormone receptor-defined molecular subtypes, menopausal status, and body size have rarely been conducted.MethodsIn the European Prospective Investigation into Cancer and Nutrition (EPIC), we investigated the associations between dietary intakes of TFAs (industrial trans fatty acids [ITFAs] and ruminant trans fatty acids [RTFAs]) and breast cancer risk among 318,607 women. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusted for other breast cancer risk factors.ResultsAfter a median follow-up of 8.1 years, 13,241 breast cancer cases occurred. In the multivariable-adjusted model, higher total ITFA intake was associated with elevated breast cancer risk (HR for highest vs lowest quintile, 1.14, 95% CI 1.06–1.23; P trend = 0.001). A similar positive association was found between intake of elaidic acid, the predominant ITFA, and breast cancer risk (HR for highest vs lowest quintile, 1.14, 95% CI 1.06–1.23; P trend = 0.001). Intake of total RTFAs was also associated with higher breast cancer risk (HR for highest vs lowest quintile, 1.09, 95% CI 1.01–1.17; P trend = 0.015). For individual RTFAs, we found positive associations with breast cancer risk for dietary intakes of two strongly correlated fatty acids (Spearman correlation r = 0.77), conjugated linoleic acid (HR for highest vs lowest quintile, 1.11, 95% CI 1.03–1.20; P trend = 0.001) and palmitelaidic acid (HR for highest vs lowest quintile, 1.08, 95% CI 1.01–1.16; P trend = 0.028). Similar associations were found for total ITFAs and RTFAs with breast cancer risk according to menopausal status, body mass index, and bre
AU  - Matta,M
AU  - Huybrechts,I
AU  - Biessy,C
AU  - Casagrande,C
AU  - Yammine,S
AU  - Fournier,A
AU  - Olsen,KS
AU  - Lukic,M
AU  - Gram,IT
AU  - Ardanaz,E
AU  - Sánchez,M-J
AU  - Dossus,L
AU  - Fortner,RT
AU  - Srour,B
AU  - Jannasch,F
AU  - Schulze,MB
AU  - Amiano,P
AU  - Agudo,A
AU  - Colorado-Yohar,S
AU  - Quirós,JR
AU  - Tumino,R
AU  - Panico,S
AU  - Masala,G
AU  - Pala,V
AU  - Sacerdote,C
AU  - Tjønneland,A
AU  - Olsen,A
AU  - Dahm,CC
AU  - Rosendahl,AH
AU  - Borgquist,S
AU  - Wennberg,M
AU  - Heath,AK
AU  - Aune,D
AU  - Schmidt,J
AU  - Weiderpass,E
AU  - Chajes,V
AU  - Gunter,MJ
AU  - Murphy,N
DO  - 10.1186/s12916-021-01952-3
EP  - 11
PY  - 2021///
SN  - 1741-7015
SP  - 1
TI  - Dietary intake of trans fatty acids and breast cancer risk in 9 European countries
T2  - BMC Medicine
UR  - http://dx.doi.org/10.1186/s12916-021-01952-3
UR  - https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-01952-3
UR  - http://hdl.handle.net/10044/1/87779
VL  - 19
ER  -
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