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@article{Aglago:2021:10.1002/ijc.33615,
author = {Aglago, EK and Murphy, N and Huybrechts, I and Nicolas, G and Casagrande, C and Fedirko, V and Weiderpass, E and Rothwell, JA and Dahm, CC and Olsen, A and Tjønneland, A and Kaaks, R and Katzke, V and Schulze, MB and Masala, G and Agnoli, C and Panico, S and Tumino, R and Sacerdote, C and BuenodeMesquita, BH and Derksen, JWG and Skeie, G and Gram, IT and Brustad, M and Jakszyn, P and Sánchez, M and Amiano, P and Huerta, JM and Ericson, U and Wennberg, M and PerezCornago, A and Heath, AK and Jenab, M and Chajes, V and Gunter, MJ},
doi = {10.1002/ijc.33615},
journal = {International Journal of Cancer},
pages = {865--882},
title = {Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the EPIC cohort},
url = {http://dx.doi.org/10.1002/ijc.33615},
volume = {149},
year = {2021}
}

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TY  - JOUR
AB  - Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrialprocessed trans (iTFA), and ruminantsourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450,112 participants (6,162 developed CRC, median followup=15 years). In a nested casecontrol study, plasma phospholipid fatty acids were determined by gas chromatography in 433 colon cancer cases and 433 matched controls. Multivariableadjusted hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed using Cox and conditional logistic regression, respectively. Dietary total SFA (highest vs. lowest quintile, HRQ5vs.Q1=0.80; 95%CI:0.690.92), myristic acid (HRQ5vs.Q1=0.83, 95%CI:0.740.93) and palmitic acid (HRQ5vs.Q1=0.81, 95%CI:0.700.93) were inversely associated with CRC risk. Plasma myristic acid was also inversely associated with colon cancer risk (highest vs. lowest quartile, ORQ4vs.Q1=0.51; 95%CI:0.320.83), whereas a borderline positive association was found for plasma stearic acid (ORQ4vs.Q1=1.63; 95%CI:1.002.64). Dietary total MUFA was inversely associated with colon cancer (per onestandard deviation increment, HR1SD=0.92, 95%CI: 0.850.98), but not rectal cancer (HR1SD=1.04, 95%CI:0.951.15, Pheterogeneity=0.027). Dietary iTFA, and particularly elaidic acid, was positively associated with rectal cancer (HR1SD =1.07, 95%CI:1.021.13). Our results suggest that total and individual saturated fatty acids and fatty acids of industrial origin may be relevant to the aetiology of CRC. Both dietary and plasma myristic acid levels were inversely associated with colon cancer risk, which warrants further investigation.
AU  - Aglago,EK
AU  - Murphy,N
AU  - Huybrechts,I
AU  - Nicolas,G
AU  - Casagrande,C
AU  - Fedirko,V
AU  - Weiderpass,E
AU  - Rothwell,JA
AU  - Dahm,CC
AU  - Olsen,A
AU  - Tjønneland,A
AU  - Kaaks,R
AU  - Katzke,V
AU  - Schulze,MB
AU  - Masala,G
AU  - Agnoli,C
AU  - Panico,S
AU  - Tumino,R
AU  - Sacerdote,C
AU  - BuenodeMesquita,BH
AU  - Derksen,JWG
AU  - Skeie,G
AU  - Gram,IT
AU  - Brustad,M
AU  - Jakszyn,P
AU  - Sánchez,M
AU  - Amiano,P
AU  - Huerta,JM
AU  - Ericson,U
AU  - Wennberg,M
AU  - PerezCornago,A
AU  - Heath,AK
AU  - Jenab,M
AU  - Chajes,V
AU  - Gunter,MJ
DO  - 10.1002/ijc.33615
EP  - 882
PY  - 2021///
SN  - 0020-7136
SP  - 865
TI  - Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the EPIC cohort
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.33615
UR  - https://onlinelibrary.wiley.com/doi/10.1002/ijc.33615
UR  - http://hdl.handle.net/10044/1/88351
VL  - 149
ER  -

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