Imperial College London
Dr Neil Murphy

DrNeilMurphy

Faculty of Medicine, School of Public Health

Honorary Senior Research Fellow
 
 
 
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Contact

 

neil.murphy

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Murphy:2023:jnci/djac215,
author = {Murphy, N and Newton, CC and Song, M and Papadimitriou, N and Hoffmeister, M and Phipps, AI and Harrison, TA and Newcomb, PA and Aglago, EK and Berndt, SI and Brenner, H and Buchanan, DD and Cao, Y and Chan, AT and Chen, X and Cheng, I and Chang-Claude, J and Dimou, N and Drew, D and Farris, AB and French, AJ and Gallinger, S and Georgeson, P and Giannakis, M and Giles, GG and Gruber, SB and Harlid, S and Hsu, L and Huang, W-Y and Jenkins, MA and Laskar, RS and Le, Marchand L and Limburg, P and Lin, Y and Mandic, M and Nowak, JA and Obón-Santacana, M and Ogino, S and Qu, C and Sakoda, LC and Schoen, RE and Southey, MC and Stadler, ZK and Steinfelder, RS and Sun, W and Thibodeau, SN and Toland, AE and Trinh, QM and Tsilidis, KK and Ugai, T and Van, Guelpen B and Wang, X and Woods, MO and Zaidi, SH and Gunter, MJ and Peters, U and Campbell, PT},
doi = {jnci/djac215},
journal = {Journal of the National Cancer Institute},
pages = {165--173},
title = {Body mass index and molecular subtypes of colorectal cancer},
url = {http://dx.doi.org/10.1093/jnci/djac215},
volume = {115},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsistent across molecular subtypes of the disease. METHODS: We pooled data on body mass index (BMI), tumor microsatellite instability status, CpG island methylator phenotype status, BRAF and KRAS mutations, and Jass classification types for 11872 CRC cases and 11013 controls from 11 observational studies. We used multinomial logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for covariables. RESULTS: Higher BMI was associated with increased CRC risk (OR per 5 kg/m2 = 1.18, 95% CI = 1.15 to 1.22). The positive association was stronger for men than women but similar across tumor subtypes defined by individual molecular markers. In analyses by Jass type, higher BMI was associated with elevated CRC risk for types 1-4 cases but not for type 5 CRC cases (considered familial-like/Lynch syndrome microsatellite instability-H, CpG island methylator phenotype-low or negative, BRAF-wild type, KRAS-wild type, OR = 1.04, 95% CI = 0.90 to 1.20). This pattern of associations for BMI and Jass types was consistent by sex and design of contributing studies (cohort or case-control). CONCLUSIONS: In contrast to previous reports with fewer study participants, we found limited evidence of heterogeneity for the association between BMI and CRC risk according to molecular subtype, suggesting that obesity influences nearly all major pathways involved in colorectal carcinogenesis. The null association observed for the Jass type 5 suggests that BMI is not a risk factor for the development of CRC for individuals with Lynch syndrome.
AU  - Murphy,N
AU  - Newton,CC
AU  - Song,M
AU  - Papadimitriou,N
AU  - Hoffmeister,M
AU  - Phipps,AI
AU  - Harrison,TA
AU  - Newcomb,PA
AU  - Aglago,EK
AU  - Berndt,SI
AU  - Brenner,H
AU  - Buchanan,DD
AU  - Cao,Y
AU  - Chan,AT
AU  - Chen,X
AU  - Cheng,I
AU  - Chang-Claude,J
AU  - Dimou,N
AU  - Drew,D
AU  - Farris,AB
AU  - French,AJ
AU  - Gallinger,S
AU  - Georgeson,P
AU  - Giannakis,M
AU  - Giles,GG
AU  - Gruber,SB
AU  - Harlid,S
AU  - Hsu,L
AU  - Huang,W-Y
AU  - Jenkins,MA
AU  - Laskar,RS
AU  - Le,Marchand L
AU  - Limburg,P
AU  - Lin,Y
AU  - Mandic,M
AU  - Nowak,JA
AU  - Obón-Santacana,M
AU  - Ogino,S
AU  - Qu,C
AU  - Sakoda,LC
AU  - Schoen,RE
AU  - Southey,MC
AU  - Stadler,ZK
AU  - Steinfelder,RS
AU  - Sun,W
AU  - Thibodeau,SN
AU  - Toland,AE
AU  - Trinh,QM
AU  - Tsilidis,KK
AU  - Ugai,T
AU  - Van,Guelpen B
AU  - Wang,X
AU  - Woods,MO
AU  - Zaidi,SH
AU  - Gunter,MJ
AU  - Peters,U
AU  - Campbell,PT
DO  - jnci/djac215
EP  - 173
PY  - 2023///
SN  - 0027-8874
SP  - 165
TI  - Body mass index and molecular subtypes of colorectal cancer
T2  - Journal of the National Cancer Institute
UR  - http://dx.doi.org/10.1093/jnci/djac215
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36445035
UR  - https://academic.oup.com/jnci/article/115/2/165/6851145?login=true
UR  - http://hdl.handle.net/10044/1/102242
VL  - 115
ER  -
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