Imperial College London

Dr Nick Powell

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Professor of Gastroenterology







Mrs Heather Bones +44 (0)20 7594 2429




Commonwealth BuildingHammersmith Campus





Nick is a Clinical Reader and consultant in Gastroenterology. His key clinical and research interests focus on intestinal inflammation in the context of inflammatory bowel diseases (such as ulcerative colitis and Crohn’s disease), but also in gut inflammation resulting from certain treatments, such as immune checkpoint inhibitors.     

His research group focuses on the molecular and cellular mechanisms responsible for mediating chronic intestinal inflammation, and understanding the dialogue between intestinal microbes and host immunity. His lab is also interested in understanding how cell-specific and tissue-specific transcriptional programmes, including cytokine-responsive networks, disclose important information about disease pathogenesis, and how these "molecular signatures" can be harnessed to predict patient outcomes.

He was previously awarded a Wellcome Trust Intermediate Clinical Fellowship (2013-2019).  He completed specialist registrar training in gastroenterology and internal medicine in London (Hammersmith, St Mary’s). He has also been awarded an MSc (Imperial College London) and PhD in immunology (King’s College London). Major funding has been awarded by the Wellcome Trust, MRC and Crohn’s and Colitis UK. Some key publications include; Powell N, et al. Gastroenterology (2015); 149:456-467, Goldberg R, et al. Nature Reviews in Gastroenterology and Hepatology (2015); 12:271-283, Powell N, et al. Immunity (2012); 37:674-84.   



Gudd C, Mitchell E, Atkinson S, et al., 2024, Therapeutic inhibition of monocyte recruitment prevents checkpoint inhibitor-induced hepatitis, Journal for Immunotherapy of Cancer, ISSN:2051-1426

Wang Y, Abu-Sbeih H, Tang T, et al., 2024, Novel endoscopic scoring system for immune mediated colitis: A Multicenter Retrospective Study of 674 Patients., Gastrointest Endosc

Alexander J, Powell N, Marchesi J, et al., 2024, Considerations for peripheral blood transport and storage during large-scale multicentre metabolome research, Gut, Vol:73, ISSN:0017-5749, Pages:379-383

Liebert A, Shapiro M, Maradana MR, et al., 2024, Dysregulation of the Environmental Sensor Aryl Hydrocarbon Receptor Affects Differentiation of Human Colon Organoids., Cell Mol Gastroenterol Hepatol, Vol:17, Pages:507-510

Burns GL, Potter M, Mathe A, et al., 2023, TRAV26-2 T-Cell Receptor Expression Is Associated With Mucosal Lymphocyte Response to Wheat Proteins in Patients With Functional Dyspepsia., Clin Transl Gastroenterol, Vol:14

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