Imperial College London
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Dr Nick Powell

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Gastroenterology
 
 
 
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Contact

 

nicholas.powell

 
 
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Assistant

 

Mrs Heather Bones +44 (0)20 7594 2429

 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ibraheim:2019:rheumatology/kez465,
author = {Ibraheim, H and Perucha, E and Powell, N},
doi = {rheumatology/kez465},
journal = {Rheumatology},
pages = {vii17--vii28},
title = {Pathology of immune-mediated tissue lesions following treatment with immune checkpoint inhibitors.},
url = {http://dx.doi.org/10.1093/rheumatology/kez465},
volume = {58},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Immune check point inhibitor (CPI) therapy has revolutionized treatment paradigms for several cancers, but at the cost of triggering a diverse spectrum of immune-mediated injury to non-cancer tissues. The complex biology of these toxicities remains incompletely understood, partly because tissue acquisition from affected areas can be challenging to retrieve, thus hindering development of targeted therapy. Here, we review the literature describing pathology of immune-mediated tissue lesions including gastrointestinal, skin, rheumatic, pulmonary, cardiac, renal and hepatic lesions and highlight key immunological insights.
AU  - Ibraheim,H
AU  - Perucha,E
AU  - Powell,N
DO  - rheumatology/kez465
EP  - 28
PY  - 2019///
SN  - 1462-0324
SP  - 17
TI  - Pathology of immune-mediated tissue lesions following treatment with immune checkpoint inhibitors.
T2  - Rheumatology
UR  - http://dx.doi.org/10.1093/rheumatology/kez465
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31816081
UR  - https://academic.oup.com/rheumatology/article/58/Supplement_7/vii17/5670493
UR  - http://hdl.handle.net/10044/1/75738
VL  - 58
ER  -
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