Publications
385 results found
Misra S, Shields B, Colclough K, et al., 2014, MODY is uncommonly diagnosed in the South Asian ethnic group as a result of difficulty in differentiating young-onset type 2 diabetes from MODY, DIABETOLOGIA, Vol: 57, Pages: S158-S158, ISSN: 0012-186X
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- Citations: 1
Fikri R, Bravis V, Gedroyc WM, et al., 2014, Conservative management of neuropathic heel ulceration with calcaneal osteomyelitis and avulsion fracture in a cohort with diabetic foot disease, DIABETOLOGIA, Vol: 57, Pages: S472-S472, ISSN: 0012-186X
Chuah LL, Miras AD, Papamargaritis D, et al., 2014, Effect of Roux-en-Y Gastric Bypass Surgery on Microvascular Complications of Type 2 Diabetes Mellitus, Publisher: AMER DIABETES ASSOC, Pages: A525-A525, ISSN: 0012-1797
Misra S, Brabarupan T, Johnston DG, et al., 2014, South Asian adults with insulin treated young-onset Type 2 diabetes have a lower body mass index and better control than other ethnic groups, DIABETIC MEDICINE, Vol: 31, Pages: 118-119, ISSN: 0742-3071
Misra S, Shields B, Colclough K, et al., 2014, MODY is uncommonly diagnosed in non-white ethnic groups as a result of difficulty in differentiating young-onset Type 2 diabetes from MODY, DIABETIC MEDICINE, Vol: 31, Pages: 138-138, ISSN: 0742-3071
Agha-Jaffar R, Reddy M, Zhang GE, et al., 2014, Diabetes recognised in early pregnancy is phenotypically Type 2 diabetes not gestational diabetes, DIABETIC MEDICINE, Vol: 31, Pages: 13-13, ISSN: 0742-3071
Muktar S, Hill N, Meegan J, et al., 2014, Glycaemic management in acute stroke, DIABETIC MEDICINE, Vol: 31, Pages: 87-87, ISSN: 0742-3071
Agha-Jaffar R, Sackay A, Teoh TG, et al., 2014, POTENTIAL BENEFITS OF CONTINUOUS GLUCOSE MONITORING IN PREDICTING FETAL OUTCOMES IN PREGNANT DIABETIC WOMEN, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 16, Pages: A134-A134, ISSN: 1520-9156
Misra S, Archer JRH, Simmgen M, et al., 2014, INTRAVENOUS INSULIN VARIABILITY PREDICTS GLYCAEMIC VARIABILITY IN INSULIN-TREATED ACUTE RESPIRATORY PATIENTS WITH DIABETES, BUT NOT THOSE WITH NORMAL GLUCOSE TOLERANCE, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 16, Pages: A139-A140, ISSN: 1520-9156
Herrero P, Liu C, Georgiou P, et al., 2014, HYPOGLYCEMIA PREDICTION BASED ON EXTENDED KALMAN FILTER USING A PHYSIOLOGICAL MODEL OF GLUCOSE REGULATION, Publisher: MARY ANN LIEBERT, INC, Pages: A82-A83, ISSN: 1520-9156
Reddy M, Oliver N, Herrero P, et al., 2014, THE IMPACT OF INSULIN INFUSION RATE VARIABILITY ON GLYCAEMIC VARIABILITY IN ADULTS WITH TYPE 1 DIABETES, Publisher: MARY ANN LIEBERT, INC, Pages: A59-A59, ISSN: 1520-9156
El-Laboudi A, Sharma S, Oliver N, et al., 2014, DEVELOPMENT OF A NOVEL MICROPROBE ARRAY CONTINUOUS GLUCOSE SENSOR FOR TYPE 1 DIABETES: INTERFERENCE STUDIES, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 16, Pages: A65-A66, ISSN: 1520-9156
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- Citations: 1
Reddy M, Oliver N, Herrero P, et al., 2014, GLYCAEMIC VARIABILITY AND QUALITY OF LIFE IN SUBJECTS WITH TYPE 1 DIABETES MELLITUS - IS THERE A CORRELATION?, Publisher: MARY ANN LIEBERT, INC, Pages: A59-A59, ISSN: 1520-9156
Pesl P, Herrero P, Reddy M, et al., 2014, Live Demonstration: An Advanced Bolus Calculator for Diabetes Management - A Clinical and Patient Platform, IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 175-175, ISSN: 2163-4025
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- Citations: 2
Herrero P, El Sharkawy M, Pesl P, et al., 2014, Live Demonstration: A Handheld Bio-inspired Artificial Pancreas for Treatment of Diabetes, IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 172-172, ISSN: 2163-4025
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- Citations: 3
Hariri AA, Oliver NS, Johnston DG, et al., 2013, Adiposity Measurements by BMI, Skinfolds and Dual Energy X-Ray Absorptiometry in relation to Risk Markers for Cardiovascular Disease and Diabetes in Adult Males, Disease Markers, Vol: 35, Pages: 753-764, ISSN: 0278-0240
Background. Choice of adiposity measure may be important in the evaluation of relationships between adiposity and risk markers for cardiovascular disease and diabetes. Aim. We explored the strengths of risk marker associations with BMI, a simple measure of adiposity, and with measures provided by skinfold thicknesses and dual energy X-ray absorptiometry (DXA). Subjects and Methods. We evaluated in three subgroups of white males (–349), participating in a health screening program, the strengths of relationship between measures of total and regional adiposity and risk markers relating to blood pressure, lipids and lipoproteins, insulin sensitivity, and subclinical inflammation. Results. Independent of age, smoking, alcohol intake, and exercise, the strongest correlations with adiposity measures were seen with serum triglyceride concentrations and indices of insulin sensitivity, with strengths of association showing little difference between BMI and skinfold and DXA measures of total and percent body fat (–0.46, ). Significant but weaker associations with adiposity were seen for serum HDL cholesterol and only relatively inconsistent associations with adiposity for total and LDL cholesterol and indices of subclinical inflammation. Conclusions. BMI can account for variation in risk markers in white males as well as more sophisticated measures derived from skinfold thickness measurements or DXA scanning.
Ramachandran A, Snehalatha C, Ram J, et al., 2013, Efficacy of mobile phone messaging in prevention of type 2 diabetes by lifestyle change in men at high risk - A randomised clinical trial in India, Journal of Association of Physicians of India, Vol: 61, Pages: 951-952, ISSN: 0004-5772
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- Citations: 1
Ramachandran A, Snehalatha C, Ram J, et al., 2013, Effectiveness of mobile phone messaging in prevention of type 2 diabetes by lifestyle modification in men in India: a prospective, parallel-group, randomised controlled trial, The Lancet Diabetes & Endocrinology, Vol: 1, Pages: 191-198, ISSN: 2213-8587
El- Laboudi A, Sharma S, Santhanam H, et al., 2013, Development Of A Novel Microprobe Array Continuous Glucose Monitor: Preclinical Validation, EASD
Background and aim: Despite clinical benefits, continuous glucose monitoring (CGM) devices are invasive and can be uncomfortable, negatively affecting concordance and effectiveness. In addition, CGM sensor accuracy is suboptimal in the critical hypoglycaemic range. To overcome these challenges, a novel continuous glucose sensor has been developed based on microprobe technology. It consists of a small, wearable patch containing several microscopic projections (microprobes) that penetrate the stratum corneum to access interstitial fluid. Aim: Mechanical and functional validation of the sensor prior to in vivo clinical studies. Mechanical validation assesses the ability to penetrate the stratum corneum without mechanical failure, while functional validation assesses the current produced in response to changing glucose concentration and the effects of sterilisation and insertion. Materials and methods: Each array had 64 microprobes arranged 8x8. Microprobe height is 1000 μm and tip diameter is 15 μm. Insertion tests were performed ex vivo in full thickness human skin. An Instron compression system was used to press the device into skin using forces of 7, 10, 15, 20 and 25 Newton. Skin penetration was confirmed by applying methylene blue dye to visualize created micropores and by histological examination. Fracture tests were performed in vitro using the Instron system to exert axial pressure against a metal probe using forces of 50, 100, 200, 300 and 400 Newton. Microprobes were examined using scanning electron microscopy before and after testing to detect failure and measure height reduction. To assess transverse fracture force, transverse pressure was exerted against one row of 8 microprobes till they fractured. Functional evaluation tests were performed in vitro by measuring the current generated in response to changing glucose concentration before and after gamma ray radiation and ex vivo skin insertion. Results: Insertion tests (n=10) demonstrated successful p
Reddy M, Herrero P, Oliver N, et al., 2013, Clinical Evaluation of the Imperial College Bio-inspired Artificial Pancreas Overnight and After Breakfast in Adults with Type 1 Diabetes, European Association for the Study of Diabetes
Brabarupan T, Misra S, Oliver NS, 2013, A comparison of type 1 diabetes phenotype in a young multi-ethnic urban population, 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S22-S22, ISSN: 0012-186X
Herrero P, Georgiou P, Oliver N, et al., 2013, A composite model of glucagon-glucose dynamics for in silico testing of bihormonal glucose controllers., J Diabetes Sci Technol, Vol: 7, Pages: 941-951
BACKGROUND: The utility of simulation environments in the development of an artificial pancreas for type 1 diabetes mellitus (T1DM) management is well established. The availability of a simulator that incorporates glucagon as a counterregulatory hormone to insulin would allow more efficient design of bihormonal glucose controllers. Existing models of the glucose regulatory system that incorporates glucagon action are difficult to identify without using tracer data. In this article, we present a novel model of glucagon-glucose dynamics that can be easily identified with standard clinical research data. METHODS: The minimal model of plasma glucose and insulin kinetics was extended to account for the action of glucagon on net endogenous glucose production by incorporating a new compartment. An existing subcutaneous insulin absorption model was used to account for subcutaneous insulin delivery. The same model of insulin pharmacokinetics was employed to model the pharmacokinetics of subcutaneous glucagon absorption. Finally, we incorporated an existing gastrointestinal absorption model to account for meal intake. Data from a closed-loop artificial pancreas study using a bihormonal controller on T1DM subjects were employed to identify the composite model. To test the validity of the proposed model, a bihormonal controller was designed using the identified model. RESULTS: Model parameters were identified with good precision, and an excellent fitting of the model with the experimental data was achieved. The proposed model allowed the design of a bihormonal controller and demonstrated its ability to improve glycemic control over a single-hormone controller. CONCLUSIONS: A novel composite model, which can be easily identified with standard clinical data, is able to account for the effect of exogenous insulin and glucagon infusion on glucose dynamics. This model represents another step toward the development of a bihormonal artificial pancreas.
Misra S, Oliver NS, Dornhorst A, 2013, PRACTICE POINTER Diabetic ketoacidosis: not always due to type 1 diabetes, BMJ-BRITISH MEDICAL JOURNAL, Vol: 346, ISSN: 1756-1833
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- Citations: 28
El-Laboudi A, Sharma S, Oliver N, et al., 2013, DEVELOPMENT OF A NOVEL MICROPROBE ARRAY CONTINUOUS GLUCOSE MONITOR: MECHANICAL CHARACTERIZATION, Advanced Technologies and Treatments for Diabetes, Publisher: Mary Ann Liebert, Inc., Publishers
Misra S, Brabarupan T, Oliver NS, 2013, Body mass index is a poor discriminator of diabetes subtype in a multi-ethnic young adult population with diabetes, DIABETIC MEDICINE, Vol: 30, Pages: 138-139, ISSN: 0742-3071
Misra S, Archer JR, Simmgen M, et al., 2013, ASSESSMENT OF GLYCAEMIC VARIABILITY (GV) IN INSULIN-TREATED ACUTE RESPIRATORY PATIENTS WITH AND WITHOUT DIABETES, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 15, Pages: A131-A132, ISSN: 1520-9156
Reddy M, Herrero P, Oliver N, et al., 2013, Clinical Assessment of the Imperial College Bio-inspired Artificial Pancreas (BiAP) in Subjects With Type 1 Diabetes Mellitus, Advanced Technologies & Treatments for Diabetes, 2013
Pesl P, Herrero P, Reddy M, et al., 2013, Parameter Tuning of a Case-Based Reasoning Algorithm for Insulin Dosing Decision Support, Advanced Technologies & Treatments for Diabetes, 2013
Dassau E, Hennings T, Fazio J, et al., 2013, Closing the Loop, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 15, Pages: S29-S39, ISSN: 1520-9156
El-Laboudi A, Oliver NS, Cass A, et al., 2013, Use of Microneedle Array Devices for Continuous Glucose Monitoring: A Review, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 15, Pages: 101-115, ISSN: 1520-9156
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- Citations: 89
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