Imperial College London
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ProfessorNickOliver

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Wynn Chair in Human Metabolism (Clinical)
 
 
 
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Contact

 

+44 (0)20 7594 1796nick.oliver

 
 
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Location

 

7S7aCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Washirasaksiri:2021:10.1038/s41598-021-91075-9,
author = {Washirasaksiri, C and Srivanichakorn, W and Godsland, IF and Kositamongkol, C and Chariyalertsak, S and Kessomboon, P and Assanangkornchai, S and Taneepanichskul, S and Neelapaichit, N and Phisalprapa, P and Johnston, DG and Oliver, NS and Aekplakorn, W},
doi = {10.1038/s41598-021-91075-9},
journal = {Scientific Reports},
title = {Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations},
url = {http://dx.doi.org/10.1038/s41598-021-91075-9},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Internationally, studies have shown associations between lipids and glycemia; however, whether the link varies by gender and population has been rarely examined. We investigated relationships between glycemia and HDL- and Non-HDL-cholesterol and their modification by gender. We undertook a cross-sectional analysis from the National Health Examination Survey for Thailand (NHES-Thailand) and the Health Survey for England (HS-England) in adults aged 18–75 year. Glycaemia was assessed by FPG in Thailand and by HbA1c in the UK. In population- and gender-stratified analyses, the relationships between glycemia and lipids were explored. A total of 15,145 Thai and 3484 UK adults with blood measurement were included. The prevalences of prediabetes were: in NHES-Thailand, 16% (SE = 0.004), based on FPG (5.6 to < 7.0 mmol/L) and in HS-England, 19% (0.007) based on HbA1c (39 to < 48 mmol/mol). Increasingly abnormal glucose homeostasis was associated with increasing age, adiposity, SBP, proportion of antihypertensive and lipid-lowering agent use and with decreasing HDL-cholesterol. Independent of age, adiposity, smoking, alcohol, physical activity, and lipid and BP lowering drug use, increasing glycemia was associated with decreasing HDL-cholesterol specifically in women with prediabetes (NHES-Thailand, beta-coefficient − 0.07 (95% CI − 0.15, − 0.001) p = 0.04 and HS-England, − 0.03 (− 0.04, − 0.006) p = 0.01). In both populations, among those with prediabetes, increasing glycaemia is associated with an adverse, significant decline in HDL cholesterol, specifically in women. These adverse effects are apparent in widely-differing international populations.
AU  - Washirasaksiri,C
AU  - Srivanichakorn,W
AU  - Godsland,IF
AU  - Kositamongkol,C
AU  - Chariyalertsak,S
AU  - Kessomboon,P
AU  - Assanangkornchai,S
AU  - Taneepanichskul,S
AU  - Neelapaichit,N
AU  - Phisalprapa,P
AU  - Johnston,DG
AU  - Oliver,NS
AU  - Aekplakorn,W
DO  - 10.1038/s41598-021-91075-9
PY  - 2021///
SN  - 2045-2322
TI  - Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-021-91075-9
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000663771500005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41598-021-91075-9
UR  - http://hdl.handle.net/10044/1/97447
VL  - 11
ER  -
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