Imperial College London
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ProfessorNickOliver

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Wynn Chair in Human Metabolism (Clinical)
 
 
 
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Contact

 

+44 (0)20 7594 1796nick.oliver

 
 
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Location

 

7S7aCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hudson:2022:10.1016/S2666-7568(22)00096-4,
author = {Hudson, J and Cruickshank, M and Quinton, R and Aucott, L and Aceves-Martins, M and Gillies, K and Bhasin, S and Snyder, PJ and Ellenberg, SS and Grossmann, M and Travison, TG and Gianatti, EJ and van, der Schouw YT and Emmelot-Vonk, MH and Giltay, EJ and Hackett, G and Ramachandran, S and Svartberg, J and Hildreth, KL and Groti, Antonic K and Brock, GB and Tenover, JL and Tan, HM and Kong, CHC and Tan, WS and Marks, LS and Ross, RJ and Schwartz, RS and Manson, P and Roberts, S and Andersen, MS and Magnussen, LV and Hernández, R and Oliver, N and Wu, F and Dhillo, WS and Bhattacharya, S and Brazzelli, M and Jayasena, CN},
doi = {10.1016/S2666-7568(22)00096-4},
journal = {The Lancet Healthy Longevity},
pages = {e381--e393},
title = {Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis.},
url = {http://dx.doi.org/10.1016/S2666-7568(22)00096-4},
volume = {3},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Testosterone is the standard treatment for male hypogonadism, but there is uncertainty about its cardiovascular safety due to inconsistent findings. We aimed to provide the most extensive individual participant dataset (IPD) of testosterone trials available, to analyse subtypes of all cardiovascular events observed during treatment, and to investigate the effect of incorporating data from trials that did not provide IPD. Methods: We did a systematic review and meta-analysis of randomised controlled trials including IPD. We searched MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE Epub Ahead of Print, Embase, Science Citation Index, the Cochrane Controlled Trials Register, Cochrane Database of Systematic Reviews, and Database of Abstracts of Review of Effects for literature from 1992 onwards (date of search, Aug 27, 2018). The following inclusion criteria were applied: (1) men aged 18 years and older with a screening testosterone concentration of 12 nmol/L (350 ng/dL) or less; (2) the intervention of interest was treatment with any testosterone formulation, dose frequency, and route of administration, for a minimum duration of 3 months; (3) a comparator of placebo treatment; and (4) studies assessing the pre-specified primary or secondary outcomes of interest. Details of study design, interventions, participants, and outcome measures were extracted from published articles and anonymised IPD was requested from investigators of all identified trials. Primary outcomes were mortality, cardiovascular, and cerebrovascular events at any time during follow-up. The risk of bias was assessed using the Cochrane Risk of Bias tool. We did a one-stage meta-analysis using IPD, and a two-stage meta-analysis integrating IPD with data from studies not providing IPD. The study is registered with PROSPERO, CRD42018111005. Findings: 9871 citations were identified through database searches and after exclusion of duplicates and of irrelevant citations, 225
AU  - Hudson,J
AU  - Cruickshank,M
AU  - Quinton,R
AU  - Aucott,L
AU  - Aceves-Martins,M
AU  - Gillies,K
AU  - Bhasin,S
AU  - Snyder,PJ
AU  - Ellenberg,SS
AU  - Grossmann,M
AU  - Travison,TG
AU  - Gianatti,EJ
AU  - van,der Schouw YT
AU  - Emmelot-Vonk,MH
AU  - Giltay,EJ
AU  - Hackett,G
AU  - Ramachandran,S
AU  - Svartberg,J
AU  - Hildreth,KL
AU  - Groti,Antonic K
AU  - Brock,GB
AU  - Tenover,JL
AU  - Tan,HM
AU  - Kong,CHC
AU  - Tan,WS
AU  - Marks,LS
AU  - Ross,RJ
AU  - Schwartz,RS
AU  - Manson,P
AU  - Roberts,S
AU  - Andersen,MS
AU  - Magnussen,LV
AU  - Hernández,R
AU  - Oliver,N
AU  - Wu,F
AU  - Dhillo,WS
AU  - Bhattacharya,S
AU  - Brazzelli,M
AU  - Jayasena,CN
DO  - 10.1016/S2666-7568(22)00096-4
EP  - 393
PY  - 2022///
SN  - 2666-7568
SP  - 381
TI  - Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis.
T2  - The Lancet Healthy Longevity
UR  - http://dx.doi.org/10.1016/S2666-7568(22)00096-4
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35711614
UR  - https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(22)00096-4/fulltext
UR  - http://hdl.handle.net/10044/1/98375
VL  - 3
ER  -
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