Imperial College London
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ProfessorNickOliver

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Wynn Chair in Human Metabolism (Clinical)
 
 
 
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Contact

 

+44 (0)20 7594 1796nick.oliver

 
 
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Location

 

7S7aCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Smith:2022:10.3390/life12071074,
author = {Smith, S and Normahani, P and Lane, T and Hohenschurz-Schmidt, D and Oliver, N and Davies, AH},
doi = {10.3390/life12071074},
journal = {Life},
pages = {1--16},
title = {Pathogenesis of distal symmetrical polyneuropathy in diabetes},
url = {http://dx.doi.org/10.3390/life12071074},
volume = {12},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Distal symmetrical polyneuropathy (DSPN) is a serious complication of diabetes associated with significant disability and mortality. Although more than 50% of people with diabetes develop DSPN, its pathogenesis is still relatively unknown. This lack of understanding has limited the development of novel disease-modifying therapies and left the reasons for failed therapies uncertain, which is critical given that current management strategies often fail to achieve long-term efficacy. In this article, the pathogenesis of DSPN is reviewed, covering pathogenic changes in the peripheral nervous system, microvasculature and central nervous system (CNS). Furthermore, the successes and limitations of current therapies are discussed, and potential therapeutic targets are proposed. Recent findings on its pathogenesis have called the definition of DSPN into question and transformed the disease model, paving the way for new research prospects.
AU  - Smith,S
AU  - Normahani,P
AU  - Lane,T
AU  - Hohenschurz-Schmidt,D
AU  - Oliver,N
AU  - Davies,AH
DO  - 10.3390/life12071074
EP  - 16
PY  - 2022///
SN  - 2075-1729
SP  - 1
TI  - Pathogenesis of distal symmetrical polyneuropathy in diabetes
T2  - Life
UR  - http://dx.doi.org/10.3390/life12071074
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000833614400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2075-1729/12/7/1074
UR  - http://hdl.handle.net/10044/1/98881
VL  - 12
ER  -
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