Imperial College London

DrNirGrossman

Faculty of MedicineDepartment of Brain Sciences

Lecturer in Dementia Research; Fellow of the UK DRi
 
 
 
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Contact

 

+44 (0)20 7594 6805nirg Website

 
 
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Location

 

E503Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

24 results found

Grossman N, Okun MS, Boyden ES, 2018, Translating Temporal Interference Brain Stimulation to Treat Neurological and Psychiatric Conditions, JAMA NEUROLOGY, Vol: 75, Pages: 1307-1308, ISSN: 2168-6149

Journal article

Schreglmann S, Wang D, Boyden E, Bhatia K, Rothwell J, Grossman Net al., 2018, Phase-locked transcranial alternating current stimulation of the cerebellum for essential tremor, International Congress of Parkinson's Disease and Movement Disorders, Publisher: WILEY, Pages: S537-S537, ISSN: 0885-3185

Conference paper

Grossman N, Bono D, Dedic N, Kodandaramaiah SB, Rudenko A, Suk H-J, Cassara AM, Neufeld E, Kuster N, Tsai L-H, Pascual-Leone A, Boyden ESet al., 2017, Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields, CELL, Vol: 169, Pages: 1029-1041.e16, ISSN: 0092-8674

We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, we can electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. We validated this temporal interference (TI) concept via modeling and physics experiments, and verified that neurons in the living mouse brain could follow the electric field envelope. We demonstrate the utility of TI stimulation by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, we show that by altering the currents delivered to a set of immobile electrodes, we can steerably evoke different motor patterns in living mice.

Journal article

Bouchard M, Fortin-Langelier E, Frenette S, Cyr G, Latreille C, Lina J, Grossman N, Carrier Jet al., 2017, IS TRANSCRANIAL ALTERNATING CURRENT STIMULATION (TACS) AN EFFECTIVE TOOL TO ENTRAIN SPINDLES DURING SLEEP IN OLDER INDIVIDUALS?, 31st Annual Meeting of the Associated-Professional-Sleep-Societies (APSS), Publisher: OXFORD UNIV PRESS INC, Pages: A105-A105

Conference paper

Nikolic K, Jarvis S, Schultz S, Grossman Net al., 2013, Controlling the neuronal balancing act: optical coactivation of excitation and inhibition in neuronal subdomains, Publisher: BioMed Central, ISSN: 1471-2202

Conference paper

Grossman N, Simiaki V, Martinet C, Toumazou C, Schultz SR, Nikolic Ket al., 2013, The spatial pattern of light determines the kinetics and modulates backpropagation of optogenetic action potentials, JOURNAL OF COMPUTATIONAL NEUROSCIENCE, Vol: 34, Pages: 477-488, ISSN: 0929-5313

Journal article

Nikolic K, Jarvis S, Grossman N, Schultz Set al., 2013, Computational Models of Optogenetic Tools for Controlling Neural Circuits with Light, 35th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC), Publisher: IEEE, Pages: 5934-5937, ISSN: 1557-170X

Conference paper

Lopes S, Davies N, Toumazou C, Grossman Net al., 2012, Theoretical Investigation of Transcranial Alternating Current Stimulation using Laminar Model, 34th Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS), Publisher: IEEE, Pages: 4152-4155, ISSN: 1557-170X

Conference paper

Manoli Z, Grossman N, Samaras T, 2012, Theoretical Investigation of Transcranial Alternating Current Stimulation using Realistic Head Model, 34th Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS), Publisher: IEEE, Pages: 4156-4159, ISSN: 1557-170X

Conference paper

Grossman N, Nikolic K, Toumazou C, Degenaar Pet al., 2011, Modeling Study of the Light Stimulation of a Neuron Cell With Channelrhodopsin-2 Mutants, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, Vol: 58, Pages: 1742-1751, ISSN: 0018-9294

Journal article

Le TT, Wilde CP, Grossman N, Cass AEGet al., 2011, A simple method for controlled immobilization of proteins on modified SAMs, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 13, Pages: 5271-5278, ISSN: 1463-9076

Journal article

McGovern B, Berlinguer-Palmini R, Grossman N, Drakakis E, Pohrer V, neil MAA, Degenaar Pet al., 2010, A new individually addressable micro-LED array for photogenetic neural stimulation, IEEE Trans. Biomedical Circuits and Systems, Vol: In press

Journal article

McGovern BP, Palmini RB, Grossman N, Neil M, Drakakis E, Degenaar PAet al., 2010, Towards an Optogenetic Retinal Prosthesis, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404

Conference paper

Grossman N, Poher V, Grubb MS, Kennedy GT, Nikolic K, McGovern B, Palmini RB, Gong Z, Drakakis EM, Neil MAA, Dawson MD, Burrone J, Degenaar Pet al., 2010, Multisite optical excitation using ChR2 and micro-LED array, Journal of Neural Engineering, Vol: 7, ISSN: 1741-2560

Journal article

McGovern B, Drakakis EM, Neil M, O'Brian P, Corbett B, Degenaar Pet al., 2010, Individually Addressable Optoelectronic Arrays for Optogenetic Neural Stimulation, IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 170-173

Conference paper

Degenaar P, Grossman N, Berlinguer-Palmini R, McGovern B, Pohrer V, Dawson M, Toumazou C, Burrone J, Nikolic K, Neil Met al., 2010, Optoelectronic microarrays for retinal prosthesis, IEEE Biomedical Circuits and Systems Conference, BioCAS 2009, Pages: 183-186

Conference paper

Nikolic K, Grossman N, Grubb M, Burrone J, Toumazou C, Degenaar Pet al., 2009, Photocycles of Channelrhodopsin-2, Photochemistry and Photobiology, Vol: 85, Pages: 400-411

Journal article

Degenaar P, Grossman N, Memon MA, Burrone J, Dawson M, Drakakis EM, Neil M, Nikolic Ket al., 2009, Optobionic vision-a new genetically enhanced light on retinal prosthesis, Journal of Neural Engineering, Vol: 6, ISSN: 1741-2560

Journal article

Grossman N, Nikolic K, Poher V, McGovern B, Drakakis EM, Neil M, Degenaar Pet al., 2009, Photostimulator for Optogenetic Retinal Prosthesis, IEEE EMBS Conference on Neural Engineering, Publisher: IEEE, Pages: 68-71

Conference paper

Poher V, Grossman N, Kennedy GT, Nikolic K, Zhang HX, Gong Z, Drakakis EM, Gu E, Dawson MD, French PMW, Degenaar P, Neil MAAet al., 2008, Micro-LED arrays: a tool for two-dimensional neuron stimulation, Journal of Physics D: Applied Physics, Vol: 41, Pages: 094014-094023, ISSN: 0022-3727

Journal article

Grossman N, Ovsianikov A, Petrov A, Eich M, Chichkov Bet al., 2007, Investigation of optical properties of circular spiral photonic crystals, OPTICS EXPRESS, Vol: 15, Pages: 13236-13243, ISSN: 1094-4087

Journal article

Nikolic K, Grossman N, Yan H, Drakakis E, Toumazou C, Degenaar Pet al., 2007, A non-invasive retinal prosthesis - testing the concept., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, Pages: 6365-6368, ISSN: 1557-170X

We have developed a testing platform for a novel type of retinal prosthesis. Our system uses an array of light sources as non-contact stimulators. The platform consists of an imaging system based on a CMOS camera, PC based image processing, and a stimulation address system carried out on a Field Programmable Gated Array which addresses a matrix array of LEDs. Special optics are used to focus the light from the LED array onto light sensitized cells.

Journal article

Nikolic K, Grossman N, Yan H, Drakakis EM, Toumazou C, Degenaar Pet al., 2007, A Non-Invasive Retinal Prosthesis - Testing the Concept, 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Publisher: IEEE, Pages: 6364-6367, ISSN: 1557-170X

Conference paper

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