27 results found
Schreglmann S, Wang D, Peach R, et al., 2020, Non-invasive Suppression of Essential Tremor via Phase-Locked Disruption of its Temporal Coherence, Nature Communications, ISSN: 2041-1723
Beppi C, Violante IR, Hampshire A, et al., 2020, Patterns of Focal- and Large-Scale Synchronization in Cognitive Control and Inhibition: A Review, FRONTIERS IN HUMAN NEUROSCIENCE, Vol: 14, ISSN: 1662-5161
Schreglmann S, Wang D, Peach R, et al., 2020, Non-invasive amelioration of essential tremor via phase-locked disruption of its temporal coherence, Publisher: Cold Spring Harbor Laboratory
Abstract Aberrant neural oscillations hallmark numerous brain disorders. Here, we first report a method to track the phase of neural oscillations in real-time via endpoint-corrected Hilbert transform (ecHT) that mitigates the characteristic Gibbs distortion. We then used ecHT to show that the aberrant neural oscillation that hallmarks essential tremor (ET) syndrome, the most common adult movement disorder, can be noninvasively suppressed via electrical stimulation of the cerebellum phase-locked to the tremor. The tremor suppression is sustained after the end of the stimulation and can be phenomenologically predicted. Finally, using feature-based statistical-learning and neurophysiological-modelling we show that the suppression of ET is mechanistically attributed to a disruption of the temporal coherence of the oscillation via perturbation of the tremor generating a cascade of synchronous activity in the olivocerebellar loop. The suppression of aberrant neural oscillation via phase-locked driven disruption of temporal coherence may represent a powerful neuromodulatory strategy to treat brain disorders.
Grossman N, Okun MS, Boyden ES, 2018, Translating Temporal Interference Brain Stimulation to Treat Neurological and Psychiatric Conditions, JAMA NEUROLOGY, Vol: 75, Pages: 1307-1308, ISSN: 2168-6149
Schreglmann S, Wang D, Boyden E, et al., 2018, Phase-locked transcranial alternating current stimulation of the cerebellum for essential tremor, International Congress of Parkinson's Disease and Movement Disorders, Publisher: WILEY, Pages: S537-S537, ISSN: 0885-3185
Grossman N, 2018, Modulation without surgical intervention Noninvasive deep brain stimulation can be achieved via temporally interfering electric fields, SCIENCE, Vol: 361, Pages: 461-462, ISSN: 0036-8075
Grossman N, Bono D, Dedic N, et al., 2017, Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields, CELL, Vol: 169, Pages: 1029-1041.e16, ISSN: 0092-8674
We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, we can electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. We validated this temporal interference (TI) concept via modeling and physics experiments, and verified that neurons in the living mouse brain could follow the electric field envelope. We demonstrate the utility of TI stimulation by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, we show that by altering the currents delivered to a set of immobile electrodes, we can steerably evoke different motor patterns in living mice.
Bouchard M, Fortin-Langelier E, Frenette S, et al., 2017, IS TRANSCRANIAL ALTERNATING CURRENT STIMULATION (TACS) AN EFFECTIVE TOOL TO ENTRAIN SPINDLES DURING SLEEP IN OLDER INDIVIDUALS?, 31st Annual Meeting of the Associated-Professional-Sleep-Societies (APSS), Publisher: OXFORD UNIV PRESS INC, Pages: A105-A105
Nikolic K, Jarvis S, Schultz S, et al., 2013, Controlling the neuronal balancing act: optical coactivation of excitation and inhibition in neuronal subdomains, Publisher: BioMed Central, ISSN: 1471-2202
Grossman N, Simiaki V, Martinet C, et al., 2013, The spatial pattern of light determines the kinetics and modulates backpropagation of optogenetic action potentials, JOURNAL OF COMPUTATIONAL NEUROSCIENCE, Vol: 34, Pages: 477-488, ISSN: 0929-5313
Nikolic K, Jarvis S, Grossman N, et al., 2013, Computational Models of Optogenetic Tools for Controlling Neural Circuits with Light, 35th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC), Publisher: IEEE, Pages: 5934-5937, ISSN: 1557-170X
Lopes S, Davies N, Toumazou C, et al., 2012, Theoretical Investigation of Transcranial Alternating Current Stimulation using Laminar Model, 34th Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS), Publisher: IEEE, Pages: 4152-4155, ISSN: 1557-170X
Manoli Z, Grossman N, Samaras T, 2012, Theoretical Investigation of Transcranial Alternating Current Stimulation using Realistic Head Model, 34th Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS), Publisher: IEEE, Pages: 4156-4159, ISSN: 1557-170X
Grossman N, Nikolic K, Toumazou C, et al., 2011, Modeling Study of the Light Stimulation of a Neuron Cell With Channelrhodopsin-2 Mutants, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, Vol: 58, Pages: 1742-1751, ISSN: 0018-9294
Le TT, Wilde CP, Grossman N, et al., 2011, A simple method for controlled immobilization of proteins on modified SAMs, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 13, Pages: 5271-5278, ISSN: 1463-9076
McGovern B, Berlinguer-Palmini R, Grossman N, et al., 2010, A new individually addressable micro-LED array for photogenetic neural stimulation, IEEE Trans. Biomedical Circuits and Systems, Vol: In press
McGovern BP, Palmini RB, Grossman N, et al., 2010, Towards an Optogenetic Retinal Prosthesis, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Grossman N, Poher V, Grubb MS, et al., 2010, Multisite optical excitation using ChR2 and micro-LED array, Journal of Neural Engineering, Vol: 7, ISSN: 1741-2560
McGovern B, Drakakis EM, Neil M, et al., 2010, Individually Addressable Optoelectronic Arrays for Optogenetic Neural Stimulation, IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 170-173
Nikolic K, Grossman N, Grubb M, et al., 2009, Photocycles of Channelrhodopsin-2, Photochemistry and Photobiology, Vol: 85, Pages: 400-411
Grossman N, Nikolic K, Poher V, et al., 2009, Photostimulator for Optogenetic Retinal Prosthesis, IEEE EMBS Conference on Neural Engineering, Publisher: IEEE, Pages: 68-71
Degenaar P, Grossman N, Memon MA, et al., 2009, Optobionic vision-a new genetically enhanced light on retinal prosthesis, Journal of Neural Engineering, Vol: 6, ISSN: 1741-2560
Poher V, Grossman N, Kennedy GT, et al., 2008, Micro-LED arrays: a tool for two-dimensional neuron stimulation, Journal of Physics D: Applied Physics, Vol: 41, Pages: 094014-094023, ISSN: 0022-3727
Grossman N, Ovsianikov A, Petrov A, et al., 2007, Investigation of optical properties of circular spiral photonic crystals, OPTICS EXPRESS, Vol: 15, Pages: 13236-13243, ISSN: 1094-4087
Nikolic K, Grossman N, Yan H, et al., 2007, A non-invasive retinal prosthesis - testing the concept., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, Pages: 6365-6368, ISSN: 1557-170X
We have developed a testing platform for a novel type of retinal prosthesis. Our system uses an array of light sources as non-contact stimulators. The platform consists of an imaging system based on a CMOS camera, PC based image processing, and a stimulation address system carried out on a Field Programmable Gated Array which addresses a matrix array of LEDs. Special optics are used to focus the light from the LED array onto light sensitized cells.
Nikolic K, Grossman N, Yan H, et al., 2007, A Non-Invasive Retinal Prosthesis - Testing the Concept, 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Publisher: IEEE, Pages: 6364-6367, ISSN: 1557-170X
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