Imperial College London
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Dr Nishel M Shah

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3315 5986nishel.shah

 
 
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Location

 

Centre for Immunology and VaccinologyChelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Greer:2019:10.3390/ijms20215388,
author = {Greer, O and Shah, NM and Sriskandan, S and Johnson, MR},
doi = {10.3390/ijms20215388},
journal = {Int J Mol Sci},
title = {Sepsis: Precision-Based Medicine for Pregnancy and the Puerperium.},
url = {http://dx.doi.org/10.3390/ijms20215388},
volume = {20},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Sepsis contributes significantly to global morbidity and mortality, particularly in vulnerable populations. Pregnant and recently pregnant women are particularly prone to rapid progression to sepsis and septic shock, with 11% of maternal deaths worldwide being attributed to sepsis. The impact on the neonate is considerable, with 1 million neonatal deaths annually attributed to maternal infection or sepsis. Pregnancy specific physiological and immunological adaptations are likely to contribute to a greater impact of infection, but current approaches to the management of sepsis are based on those developed for the non-pregnant population. Pregnancy-specific strategies are required to optimise recognition and management of these patients. We review current knowledge of the physiology and immunology of pregnancy and propose areas of research, which may advance the development of pregnancy-specific diagnostic and therapeutic approaches to optimise the care of pregnant women and their babies.
AU  - Greer,O
AU  - Shah,NM
AU  - Sriskandan,S
AU  - Johnson,MR
DO  - 10.3390/ijms20215388
PY  - 2019///
TI  - Sepsis: Precision-Based Medicine for Pregnancy and the Puerperium.
T2  - Int J Mol Sci
UR  - http://dx.doi.org/10.3390/ijms20215388
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31671794
UR  - http://hdl.handle.net/10044/1/74840
VL  - 20
ER  -
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