Imperial College London

Dr. NURA A MOHAMED

Faculty of MedicineNational Heart & Lung Institute

Honorary Research Officer
 
 
 
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Contact

 

+44 (0)20 7594 7977nura.abdi11

 
 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Published Papers

Mohameda NA,  Saleha HA, Kameno Y, Marei I, de Nuccie G, Shala BA, Shala F, Kirkby NS, Jennings L, Davies RP, Lickiss PD, and Mitchell JA (2019). Metal-organic framework (MOF) nanomedicine preparations of sildenafil designed for the future treatment of pulmonary arterial hypertension. bioRxiv   718478;    doi:  https://doi.org/10.1101/718478,

Ismail HM, Krishnamoorthy N, Al-Dewik N, Zayed H, Mohamed NA, Giacomo VD, Gupta S, Häberle J, Thöny B, Blom HJ, Kruger WD, Ben-Omran T, Nasrallah GK (2019). In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies. Hum Mutat. 2019 Feb;40(2):230-240. doi: 10.1002/humu.23682.

Mohamed NA, Davies RP, Lickiss PD, Ahmetaj-Shala B, Reed DM, Gashaw HH, Saleem H, Freeman GR , George PM. Wort SJ, Morales-Cano D, Barreira B, Tetley TD , Chester AH, Yacoub MH, Kirkby NS, Laura Moreno L and Jane A. Mitchell JA (2017). Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy. Pulmonary circulation. dio: 10.1177/2045893217710224.

Mohamed NA, Ahmetaj-Shala B, Duluc L, Mackenzie LS, Kirkby NS, Reed DM, Lickiss PD, Davies RP, Freeman GR, Wojciak-Stothard B,Chester AH, El-Sherbiny IM, Mitchell JA, Yacoub MH (2016). A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension. J Cardiovasc Transl Res. doi: 10.1007/s12265-016-9684-2.

Chan MV, Knowles RB, Lundberg MH, Tucker AT, Mohamed NA, Kirkby NS, Armstrong PC, Mitchell JA, Warner TD (2016). P2Y12 receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation. Br J Clin Pharmacol. doi:10.1111/bcp.12826.

Reed DM, Paschalaki KE, Starke RD, Mohamed NA, Sharp G, Fox B, Mitchell JA (2015). An autologous endothelial cell: peripheral blood mononuclear cell assay that detects cytokine storm responses to biologics. FASEB J. doi:10.1096/fj.14-268144.

Reed DM, Foldes G, Kirkby NS, Ahmetaj-Shala B, Mataragka S, Mohamed NA. Mitchell JA (2014). Morphology and vasoactive hormone profiles from endothelial cells derived from stem cells of different sources. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 455(3-4), 172-177. doi:10.1016/j.bbrc.2014.10.140.

Mitchell JA, Ahmetaj-Shala B, Kirkby NS, Wright WR, Mackenzie LS, Reed DM, Mohamed NA (2014). Role of prostacyclin in pulmonary hypertension. Glob Cardiol Sci Pract, 2014(4), 382393. doi:10.5339/gcsp.2014.53.

George PM, Oliver E, Dorfmuller P, Dubois OD, Reed DM, Kirkby NS, Mohamed NA, Mitchell JA (2014). Evidence for the Involvement of Type I Interferon in Pulmonary Arterial Hypertension. CIRCULATION RESEARCH, 114(4), 677- 688. doi:10.1161/CIRCRESAHA.114.302221.

Published Abstarcts

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Mohamed NA, Kameno Y, Davies RP, Lickiss PD , Marei I, Kirkby NS, Mitchell JA and Abou Saleh H. MIL-89 nanoformulation as a Platform to improve Pulmonary Arterial Hypertension Treatment. British Pharmacological Society winter Meeting (BPS), London-UK 2018.

Mohamed NA, Davies R, Lickiss PD, FreemanG, Morales D, Barreira B, Kirkby N, MorenL and Mitchell JA. In vivo assessment of metal organic framework (MOFs) for the future use as delivery agents for drugs to treat PAH, Prague- Czech Republic April 2016.

Mohamed NA, Reed DM, George PM, Wort SJ, Gashaw HH, Wright W, Yacoub MH, Chester AH and Mitchell JA. Selexipag limits inflammatory CXCL8 release from endothelial cells grown out from the blood of patients with pulmonary arterial hypertension, Actelion PH Forum Barcelona-Spain March 2016.

Mohamed NA, Ahmetaj-Shala B, Harrington LS, Kirkby NS, Reed DM, Lickiss DM, Davies RP, Wojciak-Stothard B, and Chester AH, El-Sherbini I, Mitchell JA and Yacoub M. Early preclinical results of a novel NO-nanomedicine formulation for the treatment of pulmonary hypertension. Pulmonary Vascualr Research Institute annual meeting, Guangzhou-China January 2015.

Mohamed NA, Davies R, Lickiss PD, Gashaw HH, Saleem H, Reed DM, George PM, Wort SJ, Tetley TD, Chester AH, Yacoub MH and Mitchell JA. PEGylation of the metal organic framework, MIL-89 improves stability and confers an inhibitory effect on iNOS activity in macrophages. Qatar Fondation Metting. March 2015.

Mohamed NA, Reed DM, George PM, Al-Yamani M, Wort SJ, Yacoub MH, Chester AH and Mitchell JA. Characterization Of Endothelial Cells Grown From Circulating Progenitors From Patients With Pulmonary Hypertension: Relevance To Tissue Engineering, 6th heart valve and Tissue Engeneering meeting November 2014.

Mohamed NA, Thorley AJ, Tetley TD, Yacoub MH, Chester AH, Mitchell JA. Nanoparticles Display Cell Type Specific Inflammatory Responses: Relevance to Nanomedicine in Pulmonary Hypertension. Pulmonary Hypertension Physicians Research Forum. October 2014.

Reed DM, Paschalaki KE, Mohamed NA, Gashaw HH, Bailey LK, Starke RD, Randi AM, Hansel TT, Mitchell JA. Comparison of same donor and mixed donor endothelial cell: PBMC-co-culture assay to detect cytokine storm reactions to biologics. Pharmacology 2013, London. pA2 online. December 2013.

Mohamed NA, Kameno Y, Davies RP, Lickiss PD , Marei I, Kirkby NS, Mitchell JA and Abou Saleh H. Nanomedicine Platform in the Pulmonary Arterial Hypertension. Applied Nanotechnology and Nanoscience International Conference (ANNIC), Berlin-Germany October 2018.

 Mohamed NA, Kameno Y, Davies RP, Lickiss PD , Marei I, Kirkby NS, Mitchell JA and Abou Saleh H. Metal Organic Frameworks as a Potential PAH Drug Carriers. International Conference of Nanomedicine and Nanotechnology (ICONAN), Rome-Italy 2018.

Mohamed NA, Davies R, Lickiss PD, Hira Saleem H, Reed DM, George PM, Wort SJ, Freeman G, Gutierrez LM, Morales D, Barba BB, Mitchell JA. Metal Organic Framework as a Potential Drug Carrier for Pulmonary Arterial Hypertension, Doha-Qatar March 2016.

Mohamed NA, Lickiss PD, Davies R, Saleem H, Reed DM, George PM, Wort SJ, Freeman G, Gutierrez LM, Morales D, B Barba B, Kirkby NS, Yacoub MH, Chester AH, Mitchell JA. Nanomedicine: A Potential Window to Improve Pulmonary Arterial Hypertension Therapies, December 2015.

Mohamed NA, Davies R, Lickiss PD, Saleem H, Reed DM, George PM, Wort SJ, Freeman G, Gutierrez LM, Morales D, Barreira Barba B, Jane A Mitchell JA. Metal Organic Framework as a Potential Drug Carrier for Pulmonary Arterial Hypertensio, Qatar Foundation Annual Forum, Doha-Qatar November 2015.

Mohamed NA, Lickiss PD, Davies R, Tetley TD, Yacoub MH, Chester AH, Mitchell JA. Nanotechnology Approaches to the Treatment of Pulmonary Hypertension. Pharmacology 2014, London. pA2 online. December 2014.

Mohamed NA, El Sherbiny I, Tetley TD, Yacoub MH, Chester AH, Mitchell JA. Nanoparticles display cell type specific inflammatory responses: relevance to nanomedicine in pulmonary hypertension, NHLI Postgraduate Day, London-UK June 2014.

Mohamed NA, Reed DM, George PM, Wort SJ, Wright W, Yacoub MH, Chester AH and Mitchell JA. Prostacyclin Drugs and The PPARβ Agonists GW0742 Limit Proliferation of Endothelial Cells Grown out from Human Blood and Human Microvascular Endothelial cells, Actelion PH Forum Lisbon-Portugal February 2014.

Gashaw H, Mohamed NA, Kirkby NS, Mitchell JA. Co-induction of the novel gene RGL-1 and COX-2 in human endothelial cells in vitro and in mice in vivo. Pharmacology 2013, London. pA2 online. December 2013.

Mohamed NA, Reed DM, George PM, Wort SJ, Wright WR, Yacoub M, Chester AH, Mitchell JA. Prostacyclin drugs limit proliferation of endothelial cells grown out from human blood. Pharmacology 2013, London. pA2 online. December 2013.

Mohamed NA, Reed DM, Tetley TD, Thorley AJ, Gashaw HH, Yacoub MH, Chester AH , Mitchell JA. Nanotechnology approaches to the treatment of pulmonary hypertension: Gold-nanoparticles and NO-release. Qatar Foundation Annual Research Conference, Qatar. QScience online. November 2013.



Prizes

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  • PickFord Award from the British Pharmacological Society. May 2018- May 2020.
  • Postdoctoral Research Award (PDRA) from the Qatar Foundation (QF). January 2018- January 2020.
  • National Heart and Lung Institute (NHLI) day best student poster award  30th June 2014.
  • Pharmidex best poster prize. Pharmacology 2013 (BPS Winter Meeting).
  • December 2013.Second place in the best student posters. Qatar Annual Research Forum 2013. November 2011.