Imperial College London
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Mr Oliver Boughton

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Research Fellow
 
 
 
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Contact

 

o.boughton

 
 
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Location

 

The MSk LabCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ma:2020:10.1038/s41598-020-69783-5,
author = {Ma, S and Goh, EL and Tay, T and Wiles, C and Boughton, O and Churchwell, J and Wu, Y and Karunaratne, A and Bhattacharya, R and Terrill, N and Cobb, J and Hansen, U and Abel, R},
doi = {10.1038/s41598-020-69783-5},
journal = {Scientific Reports},
pages = {1--14},
title = {Nanoscale mechanisms in age-related hip-fractures},
url = {http://dx.doi.org/10.1038/s41598-020-69783-5},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Nanoscale mineralized collagen  fibrils may  be   important  determinants  of  whole-bone mechanical properties and contribute to the risk of age-related fractures. In a cross-sectional study nano-and tissue-level mechanics were compared across trabecular sections from the proximal femora of three groups(n=10 each): ageing non-fractured donors (Controls);untreated fracture patients (Fx-Untreated); bisphosphonate-treated fracture patients (Fx-BisTreated).Collagen   fibril, mineral and   tissue mechanics   were   measured using synchrotron X-Ray diffraction,of bone sections under load. Mechanical data were compared across groups, and tissue-level data were regressed against nano. Compared to controls fracture patients exhibited significantly lower critical strain, max strain and normalized strength, with lower peak collagen and mineral strain. Bisphosphonate-treated exhibited the  lowest  properties.  In  all  three  groups,  peak mineral strain  coincided  with maximum tissue strength (i.e. ultimate stress), whilst peak fibril strain occurred afterwards(i.e. higher strain). Tissue strain and strength were positively and strongly correlated with peak fibril  and mineral strains. Age-related fractures were associated with lower peak fibril and mineral strain irrespective of treatment. Indicating earlier mineral disengagement and the subsequent onset of fibril sliding is  one of the key mechanisms  leading  to  fracture.  Treatments  for fragility  should  target collagen-mineral interactions to restore nano-scale strain to that of healthy bone.
AU  - Ma,S
AU  - Goh,EL
AU  - Tay,T
AU  - Wiles,C
AU  - Boughton,O
AU  - Churchwell,J
AU  - Wu,Y
AU  - Karunaratne,A
AU  - Bhattacharya,R
AU  - Terrill,N
AU  - Cobb,J
AU  - Hansen,U
AU  - Abel,R
DO  - 10.1038/s41598-020-69783-5
EP  - 14
PY  - 2020///
SN  - 2045-2322
SP  - 1
TI  - Nanoscale mechanisms in age-related hip-fractures
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-020-69783-5
UR  - https://www.nature.com/articles/s41598-020-69783-5
UR  - http://hdl.handle.net/10044/1/81410
VL  - 10
ER  -
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