Imperial College London

Dr Tolga Bozkurt

Faculty of Natural SciencesDepartment of Life Sciences

Reader in Molecular Plant-Microbe



+44 (0)20 7594 5381o.bozkurt




6167Sir Alexander Fleming BuildingSouth Kensington Campus






 Many filamentous plant pathogens including fungi and oomycetes are accommodated within the host cells through specialized cellular structures. For instance, some filamentous plant pathogens form specialized infection structures termed haustoria to deliver effector proteins that can modulate host immunity or mediate nutrient uptake. However, little is known about molecular mechanisms underlying microbial accommodation inside the plant cells. Our aim is to characterize the host processes required for accommodation of filamentous plant pathogens inside the plant cells with a specific focus on illustrating the role of plant endomembrane transport system and identify perturbations caused by the pathogens.

These processes have been difficult to dissect using standard genetic approaches due to overlap between focal immunity and plant development. We recently discovered that some of the Pathogen secreted effectors specifically accumulate around haustoria (perihaustorial effectors) and provide an excellent alternative to study plant focal immunity (Bozkurt et al., 2011, Saunders et al., 2012).

We deploy perihaustorial effectors as molecular probes and use a multifaceted approach including cell biology, biochemical and genetic methods to investigate the mechanisms and perturbations in host endomembrane system within the plant cells that accommodate haustoria.

More recently, our work on effector biology shed light on how plant pathogens manipulate autophagy to enable infection. This work highlighted the extensive remodeling of endomembrane compartments during plant-microbe interactions and opened up novel perspectives in understanding the role of autophagy in plant immunity. 

Model pathosystem

We mainly use haustoria forming oomycete pathogens such as Phytophthora infestans and Peronospora tabacina as well as some fungal species, which can infect the model solanaceous plant Nicotiana benthamiana.

If you are interested in joining the lab please contact



Guder F, Coatsworth P, Bozkurt O, et al., 2024, Time-resolved chemical monitoring of whole plant roots with printed electrochemical sensors and machine learning, Science Advances, Vol:10, ISSN:2375-2548

King F, Yuen ELH, Bozkurt TO, 2023, Border Control: Manipulation of the Host-Pathogen Interface by Perihaustorial Oomycete Effectors., Mol Plant Microbe Interact, ISSN:0894-0282

Moratto E, Rothery S, Bozkurt TO, et al., 2023, Enhanced germination and electrotactic behaviour of Phytophthora palmivora zoospores in weak electric fields, Physical Biology, Vol:20, ISSN:1478-3967, Pages:1-10

Shepherd S, Yuen ELH, Carella P, et al., 2023, The wheels of destruction: Plant NLR immune receptors are mobile and structurally dynamic disease resistance proteins, Current Opinion in Plant Biology, Vol:74, ISSN:1369-5266

Contreras MP, Pai H, Selvaraj M, et al., 2023, Resurrection of plant disease resistance proteins via helper NLR bioengineering, Science Advances, Vol:9, ISSN:2375-2548

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