Imperial College London
Portrait Picture

Dr Tolga Bozkurt

Faculty of Natural Sciences, Department of Life Sciences

Reader in Molecular Plant-Microbe
 
 
 
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Contact

 

+44 (0)20 7594 5381o.bozkurt

 
 
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Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bozkurt:2021:10.7554/eLife.65285,
author = {Bozkurt, O},
doi = {10.7554/eLife.65285},
journal = {eLife},
pages = {1--35},
title = {An oomycete effector subverts host vesicle trafficking to channel starvation-induced autophagy to the pathogen interface},
url = {http://dx.doi.org/10.7554/eLife.65285},
volume = {10},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Eukaryotic cells deploy autophagy to eliminate invading microbes. In turn, pathogens have evolved effector proteins to counteract antimicrobial autophagy. How adapted pathogens co opt autophagy for their own benefit is poorly understood. The Irish famine pathogen Phytophthora infestans secretes the effector protein PexRD54 that selectively activates an unknown plant autophagy pathway that antagonizes antimicrobial autophagy at the pathogen interface. Here we show that PexRD54 induces autophagosome formation by bridging vesicles decorated by the small GTPase Rab8a with autophagic compartments labelled by the core autophagy protein ATG8CL. Rab8a is required for pathogen-triggered and starvation induced but not antimicrobial autophagy, revealing specific trafficking pathways underpin selective autophagy. By subverting Rab8a mediated vesicle trafficking, PexRD54 utilizes lipid droplets to facilitate biogenesis of autophagosomes diverted to pathogen feeding sites. Altogether, we show that PexRD54 mimics starvation-induced autophagy to subvert endomembrane trafficking at the host-pathogen interface, revealing how effectors bridge distinct host compartments to expedite colonization.
AU  - Bozkurt,O
DO  - 10.7554/eLife.65285
EP  - 35
PY  - 2021///
SN  - 2050-084X
SP  - 1
TI  - An oomycete effector subverts host vesicle trafficking to channel starvation-induced autophagy to the pathogen interface
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.65285
UR  - https://elifesciences.org/articles/65285
UR  - http://hdl.handle.net/10044/1/90910
VL  - 10
ER  -
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