Imperial College London
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Dr Tolga Bozkurt

Faculty of Natural Sciences, Department of Life Sciences

Reader in Molecular Plant-Microbe
 
 
 
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Contact

 

+44 (0)20 7594 5381o.bozkurt

 
 
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Location

 

6167Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Contreras:2023:10.15252/embj.2022111519,
author = {Contreras, MP and Pai, H and Tumtas, Y and Duggan, C and Yuen, ELH and Cruces, AV and Kourelis, J and Ahn, H-K and Lee, K-T and Wu, C-H and Bozkurt, TO and Derevnina, L and Kamoun, S},
doi = {10.15252/embj.2022111519},
journal = {The EMBO Journal},
title = {Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens},
url = {http://dx.doi.org/10.15252/embj.2022111519},
volume = {42},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Nucleotidebinding domain leucinerich repeat (NLR) immune receptors are important components of plant and metazoan innate immunity that can function as individual units or as pairs or networks. Upon activation, NLRs form multiprotein complexes termed resistosomes or inflammasomes. Although metazoan paired NLRs, such as NAIP/NLRC4, form heterocomplexes upon activation, the molecular mechanisms underpinning activation of plant paired NLRs, especially whether they associate in resistosome heterocomplexes, is unknown. In asterid plant species, the NLR required for cell death (NRC) immune receptor network is composed of multiple resistance protein sensors and downstream helpers that confer immunity against diverse plant pathogens. Here, we show that pathogen effectoractivation of the NLR proteins Rx (confers virus resistance), and Bs2 (confers bacterial resistance) leads to oligomerization of their helper NLR, NRC2. Activated Rx does not oligomerize or enter into a stable complex with the NRC2 oligomer and remains cytoplasmic. In contrast, activated NRC2 oligomers accumulate in membraneassociated puncta. We propose an activationandrelease model for NLRs in the NRC immune receptor network. This points to a distinct activation model compared with mammalian paired NLRs.
AU  - Contreras,MP
AU  - Pai,H
AU  - Tumtas,Y
AU  - Duggan,C
AU  - Yuen,ELH
AU  - Cruces,AV
AU  - Kourelis,J
AU  - Ahn,H-K
AU  - Lee,K-T
AU  - Wu,C-H
AU  - Bozkurt,TO
AU  - Derevnina,L
AU  - Kamoun,S
DO  - 10.15252/embj.2022111519
PY  - 2023///
SN  - 0261-4189
TI  - Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens
T2  - The EMBO Journal
UR  - http://dx.doi.org/10.15252/embj.2022111519
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000905427700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.embopress.org/doi/full/10.15252/embj.2022111519
UR  - http://hdl.handle.net/10044/1/109013
VL  - 42
ER  -
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